Abstract: Provided herein are methods and systems for designing a radiation treatment for a subject using single arc dose painting. The methods and systems comprise an algorithm or a computer-readable product having the same, to plan the radiation treatment. The algorithm converts pairs of multiple leaf collimation (MLC) leaves to sets of leaf aperture sequences that form a shortest path single arc thereof where the pairs of MLC leaves each aligned to an intensity profile of densely-spaced radiation beams, and connects each single arc of leaf apertures to form a final treatment single arc. Also provided is a method for irradiating a tumor in a subject using single arc dose painting.

Abstract: A system and methods for the efficient segmentation of globally optimal surfaces representing object boundaries in volumetric datasets is provided. An optical surface detection system and methods are provided that are capable of simultaneously detecting multiple interacting surfaces in which the optimality is controlled by the cost functions designed for individual surfaces and by several geometric constraints defining the surface smoothness and interrelations.

Abstract: Provided herein are methods and systems for designing a radiation treatment for a subject using single arc dose painting. The methods and systems comprise an algorithm or a computer-readable product having the same, to plan the radiation treatment. The algorithm converts pairs of multiple leaf collimation (MLC) leaves to sets of leaf aperture sequences that form a shortest path single arc thereof where the pairs of MLC leaves each aligned to an intensity profile of densely-spaced radiation beams, and connects each single arc of leaf apertures to form a final treatment single arc. Also provided is a method for irradiating a tumor in a subject using single arc dose painting.

Abstract: The present invention provides a method comprising the following steps: (a) partitioning an intensity modulated beam into a set of sub-IMBs; and (b) partitioning the sub-IMBs into segments, wherein steps (a) and (b) introduce no machine delivery error. The present invention also provides a method comprising the following steps: (a) recursively partitioning an intensity modulated beam into plateaus; and (b) partitioning the plateaus into segments, wherein step (a) comprises determining a tradeoff between machine delivery error and the number of segments into which the plateaus will be partitioned in step (b).

Abstract: The present invention provides a method comprising the following steps: (a) partitioning an intensity modulated beam into a set of sub-IMBs; and (b) partitioning the sub-IMBs into segments, wherein steps (a) and (b) introduce no machine delivery error. The present invention also provides a method comprising the following steps: (a) recursively partitioning an intensity modulated beam into plateaus; and (b) partitioning the plateaus into segments, wherein step (a) comprises determining a tradeoff between machine delivery error and the number of segments into which the plateaus will be partitioned in step (b).

Abstract: The present invention provides a method comprising recursively partitioning an intensity modulated beam into plateaus; and partitioning the plateaus into segments. The present invention also provides a method for controlling administration of radiation therapy to a patient based on static leaf prescriptions. In addition, the present invention provides a method for partitioning an IMB.

Abstract: Provided herein are methods and systems for designing a radiation treatment for a subject using single arc dose painting. The methods and systems comprise an algorithm or a computer-readable product having the same, to plan the radiation treatment. The algorithm converts pairs of multiple leaf collimation (MLC) leaves to sets of leaf aperture sequences that form a shortest path single arc thereof where the pairs of MLC leaves each aligned to an intensity profile of densely-spaced radiation beams, and connects each single arc of leaf apertures to form a final treatment single arc. Also provided is a method for irradiating a tumor in a subject using single arc dose painting.