Patents by Inventor Danqi Chen
Danqi Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12400031Abstract: According to various embodiments, a method for encrypting image data for a neural network are disclosed. The method includes mixing the image data with other datapoints to form mixed data; and applying a pixel-wise random mask to the mixed data to form encrypted data. According to various embodiments, a method for encrypting text data for a neural network for natural language processing is disclosed. The method includes encoding each text datapoint via a pretrained text encoder to form encoded datapoints; mixing the encoded datapoints with other encoded datapoints to form mixed data; applying a random mask to the mixed data to form encrypted data; and incorporating the encrypted data into training a classifier of the neural network and fine-tuning the text encoder.Type: GrantFiled: June 17, 2021Date of Patent: August 26, 2025Assignee: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Sanjeev Arora, Kai Li, Yangsibo Huang, Zhao Song, Danqi Chen
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Publication number: 20250261650Abstract: Pesticidal proteins exhibiting toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC7941, TIC7941PL_1, TIC7941PL_2, and TIC7941PL_3. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding one or more of the disclosed pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Lepidopteran species pests using any of the TIC7941, TIC7941PL_1, TIC7941PL_2, and TIC7941PL_3 pesticidal proteins are also provided. Also disclosed are methods and compositions to improve the insecticidal activity of a pesticidal protein against an insect pest species.Type: ApplicationFiled: May 9, 2025Publication date: August 21, 2025Inventors: David J. Bowen, Catherine A. Chay, Danqi Chen, Todd A. Ciche, Arlene R. Howe, Jennifer L. Lutke, Barbara E. Wiggins, Yuanji Zhang
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Patent number: 12324437Abstract: Pesticidal proteins exhibiting toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC7941, TIC7941PL_1, TIC7941PL_2, and TIC7941PL_3. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding one or more of the disclosed pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Lepidopteran species pests using any of the TIC7941, TIC7941PL_1, TIC7941PL_2, and TIC7941PL_3 pesticidal proteins are also provided. Also disclosed are methods and compositions to improve the insecticidal activity of a pesticidal protein against an insect pest species.Type: GrantFiled: January 26, 2022Date of Patent: June 10, 2025Assignee: Monsanto Technology LLCInventors: David J. Bowen, Catherine A. Chay, Danqi Chen, Todd A. Ciche, Arlene R. Howe, Jennifer L. Lutke, Barbara E. Wiggins, Yuanji Zhang
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Publication number: 20250134019Abstract: The present disclosure relates to recombinant DNA molecules and engineered proteins useful for conferring tolerance to ?-triketone herbicides such as mesotrione. The present disclosure also provides herbicide tolerant transgenic plants, plant parts, cells and seeds comprising the recombinant DNA molecules, and methods of using the same.Type: ApplicationFiled: February 6, 2023Publication date: May 1, 2025Inventors: Danqi Chen, Shunhong Dai, David Duda, Stephen M. Duff, Clayton Larue, Qungang Qi, Lei Shi, Christina Taylor
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Publication number: 20230289473Abstract: According to various embodiments, a method for encrypting image data for a neural network are disclosed. The method includes mixing the image data with other datapoints to form mixed data; and applying a pixel-wise random mask to the mixed data to form encrypted data. According to various embodiments, a method for encrypting text data for a neural network for natural language processing is disclosed. The method includes encoding each text datapoint via a pretrained text encoder to form encoded datapoints; mixing the encoded datapoints with other encoded datapoints to form mixed data; applying a random mask to the mixed data to form encrypted data; and incorporating the encrypted data into training a classifier of the neural network and fine-tuning the text encoder.Type: ApplicationFiled: June 17, 2021Publication date: September 14, 2023Applicant: The Trustees of Princeton UniversityInventors: Sanjeev ARORA, Kai LI, Yangsibo HUANG, Zhao SONG, Danqi CHEN
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Patent number: 11655239Abstract: The present disclosure relates to a fused ring pyrimidine amino compound and a preparation method, a pharmaceutical composition, and a use thereof. Specifically disclosed in the present disclosure are the compound shown in formula I, a pharmaceutically acceptable salt thereof, a tautomer thereof, a stereoisomer thereof, a metabolite thereof, a metabolic precursor thereof, or a prodrug thereof. The fused ring pyrimidine amino compound of the present application has good inhibitory activity against DDRs, particularly DDR2, and has a good therapeutic effect on tumors and fibrotic diseases, especially pulmonary inflammation and pulmonary fibrosis. Also disclosed in the present disclosure are a preparation method for the compound shown in formula I, and a use thereof.Type: GrantFiled: July 17, 2020Date of Patent: May 23, 2023Assignee: Shanghai Institute Of Material Medica, Chinese Academy of SciencesInventors: Bing Xiong, Jia Li, Meiyu Geng, Jingkang Shen, Yi Zang, Jing Ai, Danqi Chen, Qi Wang, Ying Dong, Xia Peng, Yinchun Ji, Qian Tan
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Publication number: 20220274962Abstract: The present disclosure relates to a fused ring pyrimidine amino compound and a preparation method, a pharmaceutical composition, and a use thereof. Specifically disclosed in the present disclosure are the compound shown in formula I, a pharmaceutically acceptable salt thereof, a tautomer thereof, a stereoisomer thereof, a metabolite thereof, a metabolic precursor thereof, or a prodrug thereof. The fused ring pyrimidine amino compound of the present application has good inhibitory activity against DDRs, particularly DDR2, and has a good therapeutic effect on tumors and fibrotic diseases, especially pulmonary inflammation and pulmonary fibrosis. Also disclosed in the present disclosure are a preparation method for the compound shown in formula I, and a use thereof.Type: ApplicationFiled: July 17, 2020Publication date: September 1, 2022Inventors: Bing XIONG, Jia LI, Meiyu GENG, Jingkang SHEN, Yi ZANG, Jing AI, Danqi CHEN, Qi WANG, Ying DONG, Xia PENG, Yinchun JI, Qian TAN
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Publication number: 20220248686Abstract: Pesticidal proteins exhibiting toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC7941, TIC7941PL_1, TIC7941PL_2, and TIC7941PL_3. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding one or more of the disclosed pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Lepidopteran species pests using any of the TIC7941, TIC7941PL_1, TIC7941PL_2, and TIC7941PL_3 pesticidal proteins are also provided. Also disclosed are methods and compositions to improve the insecticidal activity of a pesticidal protein against an insect pest species.Type: ApplicationFiled: January 26, 2022Publication date: August 11, 2022Inventors: David J. Bowen, Catherine A. Chay, Danqi Chen, Todd A. Ciche, Arlene R. Howe, Jennifer L. Lutke, Barbana E. Wiggins, Yuanji Zhang
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Patent number: 11266151Abstract: Pesticidal proteins exhibiting toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC7941, TIC7941PL_1, TIC7941PL_2, and TIC7941PL_3. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding one or more of the disclosed pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Lepidopteran species pests using any of the TIC7941, TIC7941PL_1, TIC7941PL_2, and TIC7941PL_3 pesticidal proteins are also provided. Also disclosed are methods and compositions to improve the insecticidal activity of a pesticidal protein against an insect pest species.Type: GrantFiled: January 21, 2020Date of Patent: March 8, 2022Assignee: Monsanto Technology LLCInventors: David J. Bowen, Catherine A. Chay, Danqi Chen, Todd A. Ciche, Arlene R. Howe, Jennifer L. Lutke, Barbara E. Wiggins, Yuanji Zhang
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Publication number: 20200229445Abstract: Pesticidal proteins exhibiting toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC7941, TIC7941PL_1, TIC7941PL_2, and TIC7941PL_3. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding one or more of the disclosed pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Lepidopteran species pests using any of the TIC7941, TIC7941PL_1, TIC7941PL_2, and TIC7941PL_3 pesticidal proteins are also provided. Also disclosed are methods and compositions to improve the insecticidal activity of a pesticidal protein against an insect pest species.Type: ApplicationFiled: January 21, 2020Publication date: July 23, 2020Inventors: David J. Bowen, Catherine A Chay, Danqi Chen, Todd A. Ciche, Arlene R. Howe, Jennifer L. Lutke, Barbara E. Wiggins, Yuanji Zhang
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Patent number: 9988381Abstract: This invention provides a class of five-member-heterocycle fused pyridine compounds as shown below in Formula (X), pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof, a method of producing the same, pharmaceutical compositions containing the compound, and use of the compounds in preparing medicament for preventing and/or treating diseases and tumors associated with abnormal protein tyrosine kinase.Type: GrantFiled: June 18, 2014Date of Patent: June 5, 2018Assignees: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai Haihe Pharmaceutical Co., Ltd.Inventors: Jingkang Shen, Meiyu Geng, Jian Ding, Bing Xiong, Jing Al, Yuchi Ma, Xin Wang, Xia Peng, Yuelei Chen, Danqi Chen, Tao Meng, Lanping Ma, Yinchun Ji
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Publication number: 20160137640Abstract: This invention provides a class of five-member-heterocycle fused pyridine compounds as shown below in Formula (X), pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof, a method of producing the same, pharmaceutical compositions containing the compound, and use of the compounds in preparing medicament for preventing and/or treating diseases and tumours associated with abnormal protein tyrosine kinase.Type: ApplicationFiled: June 18, 2014Publication date: May 19, 2016Inventors: Jingkang Shen, Meiyu Geng, Jian Ding, Bing Xiong, Jing Al, Yuchi Ma, Xin Wang, Xia Peng, Yuelei Chen, Danqi Chen, Tao Meng, Lanping Ma, Yinchun Ji