Patents by Inventor Dansu Li

Dansu Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazole pyrimidine derivative and uses thereof
    Patent number: 12514859
    Abstract: The present invention provides pyrazole pyrimidine derivatives which inhibit Casein kinase I (CKI) and/or Interleukin-1 receptor-associated kinase 1 (IRAKI) and methods of their manufacture, compositions comprising them and uses thereof in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.
    Type: Grant
    Filed: February 5, 2024
    Date of Patent: January 6, 2026
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
    Inventors: Yinon Ben Neriah, Guy Brachya, Ido Burstain, Waleed Minzel, Int Snir-Alkalay, Joseph P. Vacca, Dansu Li
  • Treatment of fibrosis with IRE1 small molecule inhibitors
    Patent number: 12479818
    Abstract: Provided herein are methods of using IRE1 small molecule inhibitors in combination therapies for treating fibrosis in a subject. The IRE1 small molecule inhibitors described herein may be used in combination therapies for treating fibrosis.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: November 25, 2025
    Assignee: Cornell University
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole
  • ATR INHIBITORS
    Publication number: 20250243220
    Abstract: The disclosure provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein R?-R7 and L are defined herein: Also provided are pharmaceutical compositions, comprising one or more compounds described herein and methods of treating cancer in a patient comprising administering to the patient a compound or pharmaceutical composition described herein.
    Type: Application
    Filed: April 14, 2023
    Publication date: July 31, 2025
    Inventors: Joseph VACCA, Dansu LI, Lanqi JIA, Oren GILAD
  • PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF
    Publication number: 20250049793
    Abstract: The present invention provides pyrazole pyrimidine derivatives which inhibit Casein kinase I (CKI) and/or Interleukin-1 receptor-associated kinase 1 (IRAK1) and methods of their manufacture, compositions comprising them and uses thereof in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.
    Type: Application
    Filed: February 5, 2024
    Publication date: February 13, 2025
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yinon Ben-Neriah, Guy Brachya, Ido Burstain, Waleed Minzel, Int Snir-Alkalay, Joseph P. Vacca, Dansu Li
  • IRE1 SMALL MOLECULE INHIBITORS
    Publication number: 20240425477
    Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
    Type: Application
    Filed: June 27, 2024
    Publication date: December 26, 2024
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole
  • IRE1 small molecule inhibitors
    Patent number: 12071424
    Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
    Type: Grant
    Filed: February 28, 2023
    Date of Patent: August 27, 2024
    Assignee: Cornell University
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole
  • Pyrazole compounds and uses thereof
    Patent number: 11999721
    Abstract: The present invention provides pyrazole derivatives, e.g., a compound of Formula (I), and their uses in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.
    Type: Grant
    Filed: July 26, 2021
    Date of Patent: June 4, 2024
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
    Inventors: Dansu Li, Irit Snir-Alkalay, Joseph P. Vacca, Yinon Ben-Neriah, Avanthika Venkatachalam
  • Pyrazole pyrimidine derivative and uses thereof
    Patent number: 11925641
    Abstract: The present invention provides pyrazole pyrimidine derivatives which inhibit Casein kinase I (CKI) and/or Interleukin-1 receptor-associated kinase 1 (IRAKI) and methods of their manufacture, compositions comprising them and uses thereof in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: March 12, 2024
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
    Inventors: Yinon Ben-Neriah, Guy Brachya, Ido Burstain, Waleed Minzel, Irit Snir-Alkalay, Joseph P. Vacca, Dansu Li
  • IRE1 SMALL MOLECULE INHIBITORS
    Publication number: 20230271935
    Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
    Type: Application
    Filed: February 28, 2023
    Publication date: August 31, 2023
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole
  • IRE1 small molecule inhibitors
    Patent number: 11649224
    Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
    Type: Grant
    Filed: May 6, 2021
    Date of Patent: May 16, 2023
    Assignee: Cornell University
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Bettigole
  • IRE1 small molecule inhibitors
    Patent number: 11634403
    Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
    Type: Grant
    Filed: February 15, 2021
    Date of Patent: April 25, 2023
    Assignee: Cornell University
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole
  • COMBINATION THERAPIES WITH IRE1 SMALL MOLECULE INHIBITORS
    Publication number: 20220265656
    Abstract: Provided herein are methods of using IRE1 small molecule inhibitors in combination therapies for treating cancer in a subject. The IRE1 small molecule inhibitors described herein may be used in combination therapies for treating solid and hematologic cancers.
    Type: Application
    Filed: May 15, 2020
    Publication date: August 25, 2022
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole
  • IRE1 SMALL MOLECULE INHIBITORS
    Publication number: 20220251065
    Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
    Type: Application
    Filed: February 15, 2021
    Publication date: August 11, 2022
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole
  • TREATMENT OF FIBROSIS WITH IRE1 SMALL MOLECULE INHIBITORS
    Publication number: 20220227730
    Abstract: Provided herein are methods of using IRE1 small molecule inhibitors in combination therapies for treating fibrosis in a subject.
    Type: Application
    Filed: May 15, 2020
    Publication date: July 21, 2022
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole
  • PYRAZOLE COMPOUNDS AND USES THEREOF
    Publication number: 20220017493
    Abstract: The present invention provides pyrazole derivatives, e.g., a compound of Formula (I), and their uses in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.
    Type: Application
    Filed: July 26, 2021
    Publication date: January 20, 2022
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Dansu Li, Irit Snir-Alkalay, Joseph P. Vacca, Yinon Ben-Neriah, Avanthika Venkatachalam
  • IRE1 SMALL MOLECULE INHIBITORS
    Publication number: 20210284628
    Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
    Type: Application
    Filed: May 6, 2021
    Publication date: September 16, 2021
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole
  • PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF
    Publication number: 20210251992
    Abstract: The present invention provides pyrazole pyrimidine derivatives which inhibit Casein kinase I (CKI) and/or Interleukin-1 receptor-associated kinase 1 (IRAKI) and methods of their manufacture, compositions comprising them and uses thereof in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.
    Type: Application
    Filed: March 29, 2021
    Publication date: August 19, 2021
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yinon Ben-Neriah, Guy Brachya, Ido Burstain, Waleed Minzel, Irit Snir-Alkalay, Joseph P. Vacca, Dansu Li
  • Pyrazole compounds and uses thereof
    Patent number: 11072599
    Abstract: The present invention provides pyrazole derivatives of Formula (I), and in particular N1-(4-(5-(cyclopropylmethyl)-1-methyl-1H-pyrazol-4-yl) pyridin-2-yl)cyclohexane-1,4-diamine derivatives and related compounds as casein kinase 1 (CK1) and/or interleukin 1 receptor associated kinase 1 (IRAKI) inhibitors for treating cancer, inflammatory and immune related disorders.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: July 27, 2021
    Assignee: BioTheryX, Inc.
    Inventors: Dansu Li, Irit Snir-Alkalay, Joseph Vacca, Yinon Ben-Neriah, Avanthika Venkatachalam
  • IRE1 small molecule inhibitors
    Patent number: 11021466
    Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: June 1, 2021
    Assignee: Cornell University
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Bettigole
  • IRE1 small molecule inhibitors
    Patent number: 10961218
    Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
    Type: Grant
    Filed: July 16, 2020
    Date of Patent: March 30, 2021
    Assignee: Cornell University
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole