Abstract: A laser wakefield acceleration (LWFA) induced electron beam system for cancer therapy and diagnostics. Example embodiments presented herein include one or more laser fibers, and an electron beam source within an individual one of the one or more laser fibers, wherein the electron beam source includes a laser pulse source, a plasma target, a set of optics interposing the laser pulse source and the plasma target adapted to focus a laser pulse generated by the laser pulse source onto the plasma target, wherein interaction of the laser pulse with the plasma target induces the generation of an electron beam. In various embodiments presented herein, high energy electrons of the electron beam interact with a high-Z material to generate X-rays.