Patents by Inventor Dante ROMANINI

Dante ROMANINI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BISPECIFIC ANTIBODIES WITH CLEAVABLE C-TERMINAL CHARGE-PAIRED TAGS
    Publication number: 20220089756
    Abstract: The present invention is directed to a CH3-containing molecule comprising (a) a first polypeptide comprising a CH3 domain and a negatively charged domain comprising consecutive negatively charged amino acid residues; and (b) a second polypeptide comprising a CH3 domain and a positively charged domain comprising consecutive positively charged amino acid residues. Also provided are methods for conjugating synthetic molecules to a multi-specific antigen binding molecule.
    Type: Application
    Filed: May 8, 2019
    Publication date: March 24, 2022
    Inventors: John K. KAWOOYA, Alex W. JACOBITZ, Christopher MOHR, Stephen SMITH, Kevin GRAHAM, Ray Lieh Yoon LOW, Oliver THIEL, Dante ROMANINI, Victoria WAGNER, Neeraj J. AGRAWAL
  • METHOD OF CONJUGATION OF CYS-MABS
    Publication number: 20210346513
    Abstract: The present disclosure relates to a method of capping, reducing, and oxidizing cys-mAbs in order to provide homogenous material for subsequent conjugation reactions. The present method demonstrates robust ways to manufacture conjugates of cysteine-engineered antibodies that offer high yield and consistent product quality.
    Type: Application
    Filed: August 3, 2018
    Publication date: November 11, 2021
    Applicant: AMGEN INC.
    Inventors: Michal ACHMATOWICZ, Dante ROMANINI, James R. FALSEY, Bradley J. HERBERICH, Oliver R. THIEL
  • Pegylated carfilzomib compounds
    Patent number: 11077198
    Abstract: The present invention provides a method of treating multiple myeloma using polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: August 3, 2021
    Assignee: AMGEN INC.
    Inventors: Gary Luehr, Shabbir T. Anik, Ge Peng, Irina Dotsenko, Pasit Phiasivongsa, Dante Romanini
  • Pegylated Carfilzomib Compounds
    Publication number: 20200376131
    Abstract: The present invention provides a method of treating multiple myeloma using polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein.
    Type: Application
    Filed: April 23, 2020
    Publication date: December 3, 2020
    Applicant: AMGEN INC.
    Inventors: Gary LUEHR, Shabbir T. ANIK, Ge PENG, Irina DOTSENKO, Pasit PHIASIVONGSA, Dante ROMANINI
  • Pegylated carfilzomib compounds
    Patent number: 10675353
    Abstract: The present invention provides a method of treating multiple myeloma using polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: June 9, 2020
    Assignee: AMGEN INC.
    Inventors: Gary Luehr, Shabbir T. Anik, Ge Peng, Irina Dotsenko, Pasit Phiasivongsa, Dante Romanini
  • PEGYLATED CARFILZOMIB COMPOUNDS
    Publication number: 20200069808
    Abstract: The present invention provides a method of treating multiple myeloma using polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein.
    Type: Application
    Filed: November 5, 2019
    Publication date: March 5, 2020
    Inventors: Gary LUEHR, Shabbir T. ANIK, Ge PENG, Irina DOTSENKO, Pasit PHIASIVONGSA, Dante ROMANINI
  • Pegylated carfilzomib compounds
    Patent number: 10517954
    Abstract: The present invention provides polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein. The invention also provides methods of making and using these compounds to treat cancer, and particularly to treat hematological malignancies including multiple myeloma.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: December 31, 2019
    Assignee: Amgen Inc.
    Inventors: Gary Luehr, Shabbir T. Anik, Ge Peng, Irina Dotsenko, Pasit Phiasivongsa, Dante Romanini
  • PEGYLATED CARFILZOMIB COMPOUNDS
    Publication number: 20170340746
    Abstract: The present invention provides polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein. The invention also provides methods of making and using these compounds to treat cancer, and particularly to treat hematological malignancies including multiple myeloma.
    Type: Application
    Filed: May 23, 2017
    Publication date: November 30, 2017
    Inventors: Gary LUEHR, Shabbir T. ANIK, Ge PENG, Irina DOTSENKO, Pasit PHIASIVONGSA, Dante ROMANINI