Patents by Inventor Danutee Nitecti

Danutee Nitecti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxidation-resistant muteins of Il-2 and other protein
    Patent number: 5116943
    Abstract: A biologically active reference therapeutic protein is protected against oxidation by a method involving substituting a conservative amino acid for each methionyl residue susceptible to chloramine T or peroxide oxidation, wherein additional, non-susceptible methionyl residues are not so substituted. The oxidation-resistant mutein so produced is preferably a human mutein of interleukin-2 or interferon-.beta., and the conservative amino acid is most preferably alanine.
    Type: Grant
    Filed: May 10, 1988
    Date of Patent: May 26, 1992
    Assignee: Cetus Corporation
    Inventors: Kirston E. Koths, Robert F. Halenbeck, David F. Mark, Danutee Nitecti