Abstract: The present relates to a chip assembly, a flow cell and a cytometer for characterizing particles in a sample solution. The chip assembly comprises a pair of chips, at least one of the chip defining on its inner surface at least two channels, the two channels defining therebetween a common intersecting area. Each channel is adapted for receiving one or more optical fibers. The chips define a through-hole extending throughout the chip assembly in a transverse direction relative to the channels and passing through the common intersecting area. The flow cell comprises the chip assembly, an excitation fiber and at least one collection fiber extending through respective channels; the collection fiber for collecting light scattered or emitted by particles flowing through the through-hole and excited by an excitation light transported by the excitation fiber. The flow cytometer comprises a light source for generating the excitation light and the flow cell.

Abstract: The present relates to a chip assembly, a flow cell and a cytometer for characterizing particles in a sample solution. The chip assembly comprises a pair of chips, at least one of the chip defining on its inner surface at least two channels, the two channels defining therebetween a common intersecting area. Each channel is adapted for receiving one or more optical fibers. The chips define a through-hole extending throughout the chip assembly in a transverse direction relative to the channels and passing through the common intersecting area. The flow cell comprises the chip assembly, an excitation fiber and at least one collection fiber extending through respective channels; the collection fiber for collecting light scattered or emitted by particles flowing through the through-hole and excited by an excitation light transported by the excitation fiber. The flow cytometer comprises a light source for generating the excitation light and the flow cell.

Abstract: The present disclosure relates to the field characterization of particles in a sample solution. More specifically, the present disclosure relates to a flow cell and a method for characterizing particles by means of collected non-Gaussian temporal signals. The present flow cell and method rely on an excitation fiber with a channel. The excitation fiber has a core for transporting an excitation light generated by a light source, and defines a channel through a portion of its core. The channel of the excitation fiber directs a flow of the sample solution. The excitation fiber, the channel and collection fibers characteristics are selected, proportioned and positioned to generate collected light with a non-Gaussian temporal intensity profile.

Abstract: The present disclosure relates to the field characterization of particles in a sample solution. More specifically, the present disclosure relates to a flow cell and a method for characterizing particles by means of collected non-Gaussian temporal signals. The present flow cell and method rely on an excitation fiber with a channel. The excitation fiber has a core for transporting an excitation light generated by a light source, and defines a channel through a portion of its core. The channel of the excitation fiber directs a flow of the sample solution. The excitation fiber, the channel and collection fibers characteristics are selected, proportioned and positioned to generate collected light with a non-Gaussian temporal intensity profile.

Abstract: A non-invasive probing device wearable over a skin of a patient for monitoring the patient is provided. The probing device includes a physiological probe having a sensing interface, and a housing for housing the probe. The housing includes a body having a skin-side surface for lying next to the skin of the patient and a fixed or resilient protruding member fixedly or resiliently protruding from the skin-side surface. The protruding member houses the sensing interface. The device also includes attachment means for attaching the device to the skin of the patient. In the case of a resilient protruding member, the device may include a resilient mechanism for biasing the resilient protruding member against the body. Also in the case of a resilient protruding member, the device may include a protective cover for protecting the device against unwanted external influences.

Abstract: A method and apparatus to monitor clinical states, for example hypoglycaemia, hyperglycaemia or an ischemic state, and to detect if a user if affected by such a state. In one embodiment, the method and apparatus use a correlation between one or more non-invasive physical measurements of the body of the subject and a reference value of blood-glucose of the subject to compute an estimation parameter value, and comparing that estimation parameter value with a critical parameter value indicative of the presence of a clinical state, for example hypoglycaemia, hyperglycaemia. In another embodiment, the algorithm estimates chromophore concentrations and the scattering coefficient in order to compute a level of oxygen saturation and detect the presence of an ischemic state.

Abstract: A method and apparatus for reducing motion artifact and spurious noise effects when computing estimates of values representative of at least one physiological parameter of a subject. For motion, measured motion values are compared with a motion threshold and the taking of physiological measurements used for computing the physiological parameter estimate values are either suspended until a measured motion value is under the threshold or a correction function is applied to the physiological measurements, the correction function being based on the measured motion values. As for spurious noise, physiological measurements taken while emitters are turned off are subtracted from physiological measurements taken while emitters are turned on in order to eliminate outside noise contamination.

Abstract: A method and apparatus for estimating a body temperature and/or an ambient air temperature and/or blood flow. The method and apparatus acquire values indicative of temperature from two or more sensors. Some of the sensors being in thermal contact with a surface of the body and the other sensors being in thermal contact with the ambient air. A transfer function is then applied to the values from the sensors in order to form an estimate of the body temperature and/or the ambient air temperature and/or blood flow. The transfer function is indicative of a thermal relationship between the body temperature, the values of the sensors, the ambient air temperature and the blood flow.

Abstract: A method and apparatus for estimating a body temperature and/or an ambient air temperature and/or blood flow. The method and apparatus acquire values indicative of temperature from two or more sensors. Some of the sensors being in thermal contact with a surface of the body and the other sensors being in thermal contact with the ambient air. A transfer function is then applied to the values from the sensors in order to form an estimate of the body temperature and/or the ambient air temperature and/or blood flow.

Abstract: A method and apparatus to monitor clinical states, for example hypoglycaemia, hyperglycaemia or an ischemic state, and to detect if a user if affected by such a state. In one embodiment, the method and apparatus use a correlation between one or more non-invasive physical measurements of the body of the subject and a reference value of blood-glucose of the subject to compute an estimation parameter value, and comparing that estimation parameter value with a critical parameter value indicative of the presence of a clinical state, for example hypoglycaemia, hyperglycaemia. In another embodiment, the algorithm estimates chromophore concentrations and the scattering coefficient in order to compute a level of oxygen saturation and detect the presence of an ischemic state.