Abstract: The present invention provides a method for determining the efficacy of anti-tumor drugs in a time-efficient manner, comprising the following steps: (1) transferring a primary tumor cell into an implant device; (2) implanting the implant device comprising the primary tumor cell into an animal; (3) administering a candidate drug to the animal; (4) determining the sensitivity of the tumor cell to the candidate drug.

Abstract: The present invention relates to a human non-small cell lung cancer (NSCLC) cell line, and the use of the same in evaluating the efficacy of anti-NSCLC drugs. The present invention also discloses an animal model comprising the human NSCLC cell lines, method for producing the same and the use of the animal model in testing efficacy of drugs or obtaining pharmacological data for said drugs. The present invention also relates to a kit comprising the present human NSCLC cell lines. The present invention also disclosed methods for evaluating the efficacy of anti-NSCLC drugs by using the human NSCLC cell lines.

Abstract: The present disclosure provides a model and method for rapid screening the efficacy of immunoregulatory drugs. The method comprises constructing an animal model containing PVDF capsule tubes, and further comprises analyzing the pharmacodynamic data for the animal model in vivo, phenotype identification by paired flow cytometry and multi-omics data. The PVDF capsule tubes have cells comprising tumor cells and immune cells in a single cell suspension; wherein the tumor cells and immune cells are derived from fresh tumor tissues or body fluids of clinical patients. The animal model constructed according to the present disclosure can be used for immune system targeting and drug efficacy regulation screening, and drug screening for multiple patients at the same time. It provides a rapid and effective method and model for clinical precision medicine and new drug development.

Abstract: The disclosure provides methods for rapid screening of the efficacy of immunoregulatory drugs, especially for cancer drug screening and treatment. The methods comprise an animal model wherein polymeric capsule tubes contain cells comprising tumor cells and immune cells in a single cell suspension. The capsule device is implanted into a mouse that is treated with an anti-cancer drug, especially an immunomodulatory anti-cancer drug. The methods provide a rapid and effective way for determining a specific individual's clinical response to an immunomodulatory drug with extremely high speed and subsequent efficacious treatment in the clinical setting.

Abstract: The present invention provides a method for determining the efficacy of anti-tumor drugs in a time-efficient manner, comprising the following steps: (1) transferring a primary tumor cell into an implant device; (2) implanting the implant device comprising the primary tumor cell into an animal; (3) administering a candidate drug to the animal; (4) determining the sensitivity of the tumor cell to the candidate drug.

Abstract: A method for obtaining an animal model from conditionally reprogrammed tumor cells for screening anti-tumor drugs and a method for screening anti-tumor drugs using the same.

Abstract: The present invention provides a method for determining the efficacy of anti-tumor drugs in a time-efficient manner, comprising the following steps: (1) transferring a primary tumor cell into an implant device; (2) implanting the implant device comprising the primary tumor cell into an animal; (3) administering a candidate drug to the animal; (4) determining the sensitivity of the tumor cell to the candidate drug.