Patents by Inventor Danzhou Yang

Danzhou Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation and Uses of 7-Azaindenoisoquinolines
    Publication number: 20250074917
    Abstract: Described herein are new 8,9-dialoxy-7-azaindenoisoquinoline compounds (I), processes for their preparation, and methods of their use in the treatment of diseases responsive to inhibition of topoisomerate I and/or binding to the c-MYC G-Quadruplex.
    Type: Application
    Filed: May 1, 2023
    Publication date: March 6, 2025
    Inventors: Mark S. Cushman, Danzhou Yang, Venkat Chintareddy, Pooran Chand
  • METHODS AND MATERIALS FOR LARGE-SCALE ASSESSMENT OF LIGAND BINDING SELECTIVITY OF G-QUADRUPLEX RECOGNITION USING CUSTOM G4 MICROARRAYS
    Publication number: 20240393343
    Abstract: Described herein are devices and processes using single-stranded DNA sequences capable of forming G-quadruplexes (G4s) to assess the binding affinity and binding selectivity of potential G4-interactive ligands.
    Type: Application
    Filed: April 26, 2024
    Publication date: November 28, 2024
    Inventors: Danzhou Yang, Guanhui Wu, Charles Vinson
  • Preparation and Uses of 7-Azaindenoisoquinolines
    Publication number: 20240287089
    Abstract: Described herein are new 8,9-dialoxy-7-azaindenoisoquinoline compounds (I), processes for their preparation, and methods of their use in the treatment of diseases responsive to inhibition of topoisomerate I and/or binding to the c-MYC G-Quadruplex.
    Type: Application
    Filed: March 27, 2024
    Publication date: August 29, 2024
    Inventors: Mark S. Cushman, Danzhou Yang, Venkat Chintareddy, Pooran Chand
  • PATIENT SELECTION FOR TREATMENT OF MYC POSITIVE CANCERS WITH INDENOISOQUINOLINES
    Publication number: 20210382058
    Abstract: The present disclosure is directed to a method for selecting a patient with cancer for treatment with a compound of formula (I) by determining if the patient's cancer cells are MYC-positive and when the MYC promoter sequence in those cancer cells contains a nucleic acid sequence capable of forming a MYC G-quadruplex (MYC G4) (i.e. are MYC G4-positive) and treating the patient with a compound of formula (I).
    Type: Application
    Filed: May 28, 2021
    Publication date: December 9, 2021
    Inventors: Mark S. Cushman, Danzhou Yang, Guanhui Wu, Kaibo Wang
  • METHODS AND MATERIALS FOR LARGE-SCALE ASSESSMENT OF LIGAND BINDING SELECTIVITY OF G-QUADRUPLEX RECOGNITION USING CUSTOM G4 MICROARRAYS
    Publication number: 20210333284
    Abstract: Described herein are devices and processes using single-stranded DNA sequences capable of forming G-quadruplexes (G4s) to assess the binding affinity and binding selectivity of potential G4-interactive ligands.
    Type: Application
    Filed: April 27, 2021
    Publication date: October 28, 2021
    Inventors: Danzhou YANG, Guanhui WU, Charles VINSON
  • Oligonucleotide delivery systems for camptothecins
    Patent number: 6897200
    Abstract: Camptothecin drugs are stabilized in their antitumor active lactone form by complexation with an oligonucleotide including RNA or catalytic RNA. The oligonucleotide-camptothecin drug complex may be incorporated within a macromolecular assembly including both viral and non-viral oligonucleotide vectors. The invention allows combination gene and camptothecin drug therapy.
    Type: Grant
    Filed: October 14, 1998
    Date of Patent: May 24, 2005
    Assignee: University of Kentucky Research Foundation
    Inventors: Thomas G. Burke, Ayhan S. Demir, Ashok J. Chavan, Danzhou Yang