Patents by Inventor Daojing Wang

Daojing Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10928401
    Abstract: The present disclosure provided methods and systems for diagnosing diseases and monitoring their progression and therapeutic responses by detecting a presence or absence, or an increase or decrease, of one or more substances in a sample.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: February 23, 2021
    Assignee: NEWOMICS INC.
    Inventors: Daojing Wang, Pan Mao
  • Publication number: 20210008553
    Abstract: The present disclosure provides methods and systems for separating one or more target analytes from a fluid sample. The systems may comprise a microfluidic device. The microfluidic device may comprise a fluidic channel having an array of obstacles disposed therein. The array of obstacles may be oriented at an angle greater than 0° relative to a direction of a fluid flow in the fluidic channel. The array of obstacles may be configured to separate the target analytes from the fluid upon flow of the fluid through the fluidic channel. The methods of the present disclosure may comprise separating target analytes from a fluid using a microfluidic device comprising obstacles disposed in a fluidic channel of the device. The target analytes may be separated with a high efficiency, sensitivity and/or specificity.
    Type: Application
    Filed: April 29, 2020
    Publication date: January 14, 2021
    Inventors: Daojing WANG, Yuchao CHEN, Pan MAO
  • Patent number: 10627395
    Abstract: The present disclosure provides methods and systems for detecting a presence or absence of one or more analytes in small volumes of samples. The detected presence or absence of the one or more analytes can be used for a variety of applications including biomonitoring.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: April 21, 2020
    Assignee: NEWOMICS INC.
    Inventors: Daojing Wang, Pan Mao
  • Publication number: 20200081014
    Abstract: The present disclosure provided methods and systems for diagnosing diseases and monitoring their progression and therapeutic responses by detecting a presence or absence, or an increase or decrease, of one or more substances in a sample.
    Type: Application
    Filed: May 14, 2019
    Publication date: March 12, 2020
    Inventors: Daojing Wang, Pan Mao
  • Patent number: 10338079
    Abstract: The present disclosure provided methods and systems for diagnosing diseases and monitoring their progression and therapeutic responses by detecting a presence or absence, or an increase or decrease, of one or more substances in a sample.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: July 2, 2019
    Assignee: NEWOMICS INC.
    Inventors: Daojing Wang, Pan Mao
  • Patent number: 10203307
    Abstract: Systems, methods, and apparatus provide integration of microscopic imaging and liquid chromatography-mass spectrometry on a microfluidic device. In one aspect, an apparatus includes a first wafer, a second wafer, and an emitter. The emitter is disposed between the first wafer and the second wafer. The first wafer defines a sample input hole. The first wafer and the second wafer define a first channel, the first channel including a first end and a second end. The first end of the first channel is proximate the sample input hole. The first channel is configured to contain separation media. The second end of the first channel is proximate the emitter.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: February 12, 2019
    Assignee: The Regents of the University of California
    Inventors: Daojing Wang, Pan Mao, Rafael Gomez-Sjoberg, Hung-Ta Wang, Peidong Yang
  • Publication number: 20180038850
    Abstract: The present disclosure provides methods and systems for detecting a presence or absence of one or more analytes in small volumes of samples. The detected presence or absence of the one or more analytes can be used for a variety of applications including biomonitoring.
    Type: Application
    Filed: October 18, 2017
    Publication date: February 8, 2018
    Inventors: Daojing Wang, Pan Mao
  • Patent number: 9793477
    Abstract: The present invention provides for a structure comprising a plurality of emitters, wherein a first nozzle of a first emitter and a second nozzle of a second emitter emit in two directions that are not or essentially not in the same direction; wherein the walls of the nozzles and the emitters form a monolithic whole. The present invention also provides for a structure comprising an emitter with a sharpened end from which the emitter emits; wherein the emitters forms a monolithic whole. The present invention also provides for a fully integrated separation of proteins and small molecules on a silicon chip before the electrospray mass spectrometry analysis.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: October 17, 2017
    Assignee: The Regents of The University of California
    Inventors: Daojing Wang, Pan Mao, Hung-Ta Wang, Peidong Yang
  • Publication number: 20170003294
    Abstract: The present disclosure provided methods and systems for diagnosing diseases and monitoring their progression and therapeutic responses by detecting a presence or absence, or an increase or decrease, of one or more substances in a sample.
    Type: Application
    Filed: July 6, 2016
    Publication date: January 5, 2017
    Inventors: Daojing Wang, Pan Mao
  • Publication number: 20150293063
    Abstract: This disclosure provides systems, methods, and apparatus for integration of microscopic imaging and liquid chromatography-mass spectrometry on a microfluidic device. In one aspect, an apparatus includes a first wafer, a second wafer, and an emitter. The emitter is disposed between the first wafer and the second wafer. The first wafer defines a sample input hole. The first wafer and the second wafer define a first channel, the first channel including a first end and a second end. The first end of the first channel is proximate the sample input hole. The first channel is configured to contain separation media. The second end of the first channel is proximate the emitter.
    Type: Application
    Filed: June 3, 2015
    Publication date: October 15, 2015
    Inventors: Daojing Wang, Pan Mao, Rafael Gomez-Sjoberg, Hung-Ta Wang, Peidong Yang
  • Publication number: 20140110661
    Abstract: The present invention provides for a structure comprising a plurality of emitters, wherein a first nozzle of a first emitter and a second nozzle of a second emitter emit in two directions that are not or essentially not in the same direction; wherein the walls of the nozzles and the emitters form a monolithic whole. The present invention also provides for a structure comprising an emitter with a sharpened end from which the emitter emits; wherein the emitters forms a monolithic whole. The present invention also provides for a fully integrated separation of proteins and small molecules on a silicon chip before the electrospray mass spectrometry analysis.
    Type: Application
    Filed: December 20, 2013
    Publication date: April 24, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Daojing Wang, Pan Mao, Hung-Ta Wang, Peidong Yang
  • Patent number: 8022361
    Abstract: Novel and significantly simplified procedures for fabrication of fully integrated nanoelectrospray emitters have been described. For nanofabricated monolithic multinozzle emitters (NM2 emitters), a bottom up approach using silicon nanowires on a silicon sliver is used. For microfabricated monolithic multinozzle emitters (M3 emitters), a top down approach using MEMS techniques on silicon wafers is used. The emitters have performance comparable to that of commercially-available silica capillary emitters for nanoelectrospray mass spectrometry.
    Type: Grant
    Filed: October 28, 2008
    Date of Patent: September 20, 2011
    Assignee: The Regents of the University of California
    Inventors: Daojing Wang, Peidong Yang, Woong Kim, Rong Fan
  • Publication number: 20100075428
    Abstract: Novel and significantly simplified procedures for fabrication of fully integrated nanoelectrospray emitters have been described. For nanofabricated monolithic multinozzle emitters (NM2 emitters), a bottom up approach using silicon nanowires on a silicon sliver is used. For microfabricated monolithic multinozzle emitters (M3 emitters), a top down approach using MEMS techniques on silicon wafers is used. The emitters have performance comparable to that of commercially-available silica capillary emitters for nanoelectrospray mass spectrometry.
    Type: Application
    Filed: October 28, 2008
    Publication date: March 25, 2010
    Applicant: The Regents of the University of California
    Inventors: Daojing Wang, Peidong Yang, Woong Kim, Rong Fan