Patents by Inventor Daopeng Chen

Daopeng Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the manufacture of agomelatine and its intermediate
    Patent number: 8653281
    Abstract: A process for the manufacture of agomelatine and its intermediate N-[2-(7-methoxy- 1-naphthy)ethyl]phthalimide is provided and inclues reacting 7-methoxy-1-naphthyl ethanol (III) with benzenesulfonyl chloride to obtain 7-methoxy-1 -naphthylethyl benzene sulfonate (IV), which is reacted with potassium phthalimide to produce N-[2-(7-methoxy-1-naphthy)ethyl]phthalimide (II); and subjecting N-[2-(7-methoxy-1-naphthy)ethyl]phthalimide (II) to alkaline hydrolysis and acetylation, to obtain agomelatine.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: February 18, 2014
    Assignee: NHWA Pharma. Corporation
    Inventors: Guisen Zhang, Daopeng Chen, Yanqin Ma, Xiangping Yang, Shixia Zhou, Liang Chen
  • PROCESS FOR THE MANUFACTURE OF AGOMELATINE AND ITS INTERMEDIATE
    Publication number: 20110130571
    Abstract: A process for the manufacture of agomelatine and its intermediate N-[2-(7-methoxy-1-naphthyl)ethyl]phthalimide is provided and includes reacting 7-methoxy-1-naphthyl ethanol (III) with benzenesulfonyl chloride to obtain 7-methoxy-1-naphthylethyl benzene sulfonate (IV), which is reacted with potassium phthalimide to produce N-[2-(7-methoxy-1-naphthyl)ethyl]phthalimide (II); and subjecting N-[2-(7-methoxy-1-naphthyl)ethyl]phthalimide (II) to alkaline hydrolysis and acetylation, to obtain agomelatine.
    Type: Application
    Filed: July 23, 2009
    Publication date: June 2, 2011
    Inventors: Guisen Zhang, Daopeng Chen, Yanqin Ma, Xiangping Yang, Shixia Zhou, Liang Chen