Patents by Inventor Daphna Miron

Daphna Miron has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF PURIFYING AND QUALIFYING ANTIBODIES
    Publication number: 20190211055
    Abstract: A method of purifying a recombinant antibody having the complementarity determining regions (CDRs) of denosumab, the method comprising subjecting a preparation comprising said antibody to a mixed mode chromatography on a Capto™ Adhere column in a pH range of 6.2-7.4, thereby purifying the antibody.
    Type: Application
    Filed: September 14, 2017
    Publication date: July 11, 2019
    Inventor: Daphna MIRON
  • METHODS FOR COVALENTLY ATTACHING A POLYMER TO A METHIONINE RESIDUE IN PROTEINS AND PEPTIDES
    Publication number: 20110150820
    Abstract: Conjugates of polypeptides and a polymeric moiety such as PEG covalently attached to the sulfur atom of a methionine side chain are disclosed. Processes of preparing such conjugates, including intermediates and reagents utilized therefore are also disclosed. Further disclosed are therapeutic uses of these conjugates.
    Type: Application
    Filed: August 27, 2009
    Publication date: June 23, 2011
    Applicant: Insight Biopharmaceuticals Ltd.
    Inventors: Joel M. Van Gelder, Andrei Serban, Susanna Tchilibon, Daphna Miron
  • Heparanase inhibitors and uses thereof
    Publication number: 20070185176
    Abstract: The invention provides heparanase inhibitors suitable for treatment of diseases and disorders caused by or associated with heparanase catalytic activity such as cancer, inflammatory disorders and autoimmune diseases.
    Type: Application
    Filed: February 6, 2005
    Publication date: August 9, 2007
    Applicant: Insight Bioharmaceuticals Ltd.
    Inventors: Joel Van Gelder, Yochai Basel, Boris Kraiz, Orly Mouallem, Daphna Miron, Nina Gur-Arie, Joseph Klein
  • Heparanase activity neutralizing anti-heparanase monclonal antibody and other anti-heparanase antibodies
    Publication number: 20060269552
    Abstract: Specific anti-heparanase antibodies which bind specifically to heparanase having sequence homology to human heparanase, which can be used to treat and diagnose conditions associated with heparanase catalytic activity, for purification of heparanase, and for drug development in heparanase associated conditions are disclosed.
    Type: Application
    Filed: June 3, 2004
    Publication date: November 30, 2006
    Inventors: Oron Yacoby-Zeevi, Tuvia Peretz, Daphna Miron, Yinon Shlomi, Iris Pecker, Maty Ayal-Hershkovitz
  • Heparanase activity neutralizing anti-heparanase monoclonal antibody
    Patent number: 6946131
    Abstract: A method of treating a condition associated with heparanase expression by administering a heparanase activity neutralizing monoclonal anti-heparanase antibody, the monoclonal anti-heparanase antibody being for neutralizing heparanase catalytic activity.
    Type: Grant
    Filed: February 19, 2003
    Date of Patent: September 20, 2005
    Assignees: InSight Biopharmacenticals Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Tuvia Peretz, Daphna Miron, Yinon Shlomi, Iris Pecker, Maty Ayal-Hershkovitz, Israel Vlodavsky, Yael Friedmann
  • Methods and pharmaceutical compositions for modulating heparanase activation and uses thereof
    Publication number: 20050042213
    Abstract: Methods of identifying proteases participating in heparanase activation, methods and pharmaceutical compositions useful in modulating heparanase activation and methods of modulating biological processes depending, at least in part, on heparanase activity are disclosed.
    Type: Application
    Filed: August 12, 2004
    Publication date: February 24, 2005
    Inventors: Joel Gelder, Daphna Miron
  • Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies
    Publication number: 20040213789
    Abstract: Specific anti-heparanase antibodies which bind specifically to heparanase having sequence homology to human heparanase, which can be used to treat and diagnose conditions associated with heparanase catalytic activity, for purification of heparanase, and for drug development in heparanase associated conditions are disclosed.
    Type: Application
    Filed: August 22, 2003
    Publication date: October 28, 2004
    Inventors: Oron Yacoby-Zeevi, Tuvia Peretz, Daphna Miron, Yinon Shlomi, Iris Pecker, Maty Ayal-Hershkovitz, Elena Feinstein, Joel M. Van Gelder, Israel Vlodavsky, Yael Friedmann
  • Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies
    Publication number: 20040170631
    Abstract: Specific anti-heparanase antibodies which bind specifically to heparanase having sequence homology to human heparanase, which can be used to treat and diagnose conditions associated with heparanase catalytic activity, for purification of heparanase, and for drug development in heparanase associated conditions are disclosed.
    Type: Application
    Filed: November 28, 2003
    Publication date: September 2, 2004
    Inventors: Oron Yacoby-Zeevi, Tuvia Peretz, Daphna Miron, Yinon Shlomi, Iris Pecker, Maty Ayal-Hershkovitz, Elena Feinstein, Joel M. Van Gelder, Israel Vlodavsky, Yael Friedmann
  • Heparanase activity neutralizing anti-heparanase monoclonal antibody
    Publication number: 20030181687
    Abstract: A method of treating a condition associated with heparanase expression by administering a heparanase activity neutralizing monoclonal anti-heparanase antibody, the monoclonal anti-heparanase antibody being for neutralizing heparanase catalytic activity.
    Type: Application
    Filed: February 19, 2003
    Publication date: September 25, 2003
    Inventors: Tuvia Peretz, Daphna Miron, Yinon Shlomi, Iris Pecker, Maty Ayal-Hershkovitz, Israel Vlodavsky, Yael Friedmann
  • Heparanase activity neutralizing anti-heparanase monoclonal antibody
    Patent number: 6562950
    Abstract: A monoclonal antibody elicited by a heparanase protein or an immunogenical portion thereof, the monoclonal antibody specifically inhibits heparanase activity.
    Type: Grant
    Filed: November 4, 1998
    Date of Patent: May 13, 2003
    Assignees: Insight Strategy & Marketing Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Tuvia Peretz, Daphna Miron, Yinon Shlomi, Iris Pecker, Maty Ayal-Hershkovitz, Israel Vlodavsky, Yael Friedmann
  • Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same
    Patent number: 6475763
    Abstract: Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active heparanase by proteolysis.
    Type: Grant
    Filed: January 19, 2000
    Date of Patent: November 5, 2002
    Assignee: Insight Strategy & Marketing Ltd.
    Inventors: Maty Ayal-Hershkovitz, Haim Moskowitz, Daphna Miron, Ayelet Gilboa, Madlene Mimon, Hanna Ben-Artzi, Oron Yacoby-Zeevi, Iris Pecker, Yoav Peleg, Yinon Shlomi
  • HEPARANASE ACTIVITY NEUTRALIZING ANTI-HEPARANASE MONOCLONAL ANTIBODY
    Publication number: 20020068061
    Abstract: A monoclonal antibody elicited by a heparanase protein or an immunogenical portion thereof, the monoclonal antibody specifically inhibits heparanase activity.
    Type: Application
    Filed: November 4, 1998
    Publication date: June 6, 2002
    Inventors: TUVIA PERETZ, DAPHNA MIRON, YINON SHLOMI, IRIS PECKER, MATY AYAL-HERSHKOVITZ, ISREAL VLODAVSKY, YAEL FRIEDMANN
  • Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same
    Patent number: 6348344
    Abstract: Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active heparanase by proteolysis.
    Type: Grant
    Filed: March 2, 1999
    Date of Patent: February 19, 2002
    Assignee: Insight Strategy & Marketing Ltd.
    Inventors: Maty Ayal-Hershkovitz, Haim Moskowitz, Daphna Miron, Ayelet Gilboa, Madelene Mimon, Hanna Ben-Artzi, Oron Yacoby-Zeevi, Iris Pecker, Yoav Peleg, Yinon Schlomi
  • Heparin and heparan sulfate derived oligosaccharides and a method for their manufacture
    Publication number: 20020009782
    Abstract: A method of preparing low molecular weight heparin or low molecular weight heparan sulfate, the method is effected by digesting unfractionated or partially fractionated heparin or heparan sulfate having a given preponderant molecular mass with heparanase, thereby obtaining beparin or heparan sulfate of a lower preponderant molecular mass. A product obtained by implementing the method and a pharmaceutical composition including the latter are also described.
    Type: Application
    Filed: September 4, 2001
    Publication date: January 24, 2002
    Inventor: Daphna Miron
  • Method of screening for potential anti-metastatic and anti-inflammatory agents using mammalian heparanase as a probe
    Patent number: 6190875
    Abstract: Qualitative and quantitative methods of testing an agent for its potential at inhibiting glycosidase catalytic activity, the methods including the steps of interacting a glycosidase enzyme with a glycosidase substrate in a presence of the agent and qualitatively or quantitatively evaluating an effect of the agent on the catalytic activity of the glycosidase enzyme toward the glycosidase substrate. Preferably the glycosidase enzyme is a heparanase enzyme and the glycosidase substrate is, respectively, a heparanase substrate.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: February 20, 2001
    Assignees: Insight Strategy & Marketing Ltd., Hadasit Medical Research & Development Ltd.
    Inventors: Hanna Ben-Artzi, Maty Ayal-Hershkovitz, Israel Vlodavsky, Iris Pecker, Yoav Peleg, Daphna Miron