Abstract: A clip applying mechanism and a clip applying apparatus thereof are provided. The clip applying mechanism includes a tube body, a main shaft, a clip-cartridge assembly and a clip-pushing assembly; and further includes: a main-shaft connecting member, sleeved on the main shaft and connected with the main shaft; the main-shaft connecting member being configured to move in a same direction as the main shaft in an axial direction of the tube body; a housing, configured to accommodate the main shaft and the main-shaft connecting member; and a locking mechanism, arranged between the main-shaft connecting member and the housing; in a case that the clip is conveyed into the end effector, the main-shaft connecting member and the housing are locked with each other through the locking mechanism.

Abstract: A surgical instrument, including an openable/closable staple cartridge and a staple anvil. The staple cartridge has a staple cartridge surface facing the staple anvil (200). The staple cartridge is further provided with a staple recess extending in a direction perpendicular to the staple cartridge surface. A staple and a staple pushing piece are accommodated in the staple recess. The staple pushing piece is arranged at the side of the staple away from the staple cartridge surface, and the staple pushing piece is provided with a staple pushing surface used for contacting the staple so as to push the staple. The staple cartridge is configured such that when the staple pushing piece pushes the staple towards the staple anvil to move to a maximum displacement position, the staple pushing surface of the staple pushing piece is flush with the staple cartridge surface or lower than the staple cartridge surface.

Abstract: A clip applying mechanism and a clip applying apparatus thereof are provided. The clip applying mechanism includes a tube body, a main shaft, a clip-cartridge assembly, a clip-pushing assembly and a firing assembly; and further includes: a main-shaft connecting member, connected with the main shaft; a firing connecting member, connected with the firing assembly; an engagement mechanism, arranged between the main-shaft connecting member and the firing connecting member. The engagement mechanism, the firing connecting member, the main-shaft connecting member and the firing assembly are configured such that: in a case where the clip is fired, the main-shaft connecting member drives the firing connecting member to move in a direction facing away from the head end of the tube body through the engagement mechanism, and the firing connecting member drives the firing assembly to move in a same direction, so that the end effector is partially opened.

Abstract: A clip applying mechanism and a clip applying apparatus thereof. The clip applying mechanism includes a tube body, a main shaft, a clip-cartridge assembly, a clip-pushing assembly and a firing assembly; and further includes: a main-shaft connecting member, sleeved on the main shaft and connected with the main shaft; a housing, configured to accommodate the main shaft and the main-shaft connecting member, the main-shaft connecting member being configured to be capable of moving relative to the housing in an axial direction of the tube body and in a circumferential direction of the tube body; a limiting mechanism, arranged between the main-shaft connecting member and the housing, the limiting mechanism being configured to limit a movement range of the main-shaft connecting member relative to the housing.

Abstract: A clip applying mechanism and a clip applying apparatus thereof are provided. The clip applying mechanism includes a tube body, a main shaft, a clip-cartridge assembly, a clip-pushing assembly and a firing assembly; and further includes: a main-shaft connecting member, sleeved on the main shaft and connected with the main shaft; a housing, configured to accommodate the main shaft and the main-shaft connecting member, the main-shaft connecting member being configured to move relative to the housing in an axial direction of the tube body and in a circumferential direction of the tube body; a first guiding mechanism, arranged between the main-shaft connecting member and the housing, the first guiding mechanism being configured to guide the main-shaft connecting member to move relative to the housing.

Abstract: A surgical instrument, including an openable/closable staple cartridge and a staple anvil. The staple cartridge has a staple cartridge surface facing the staple anvil (200). The staple cartridge is further provided with a staple recess extending in a direction perpendicular to the staple cartridge surface. A staple and a staple pushing piece are accommodated in the staple recess. The staple pushing piece is arranged at the side of the staple away from the staple cartridge surface, and the staple pushing piece is provided with a staple pushing surface used for contacting the staple so as to push the staple. The staple cartridge is configured such that when the staple pushing piece pushes the staple towards the staple anvil to move to a maximum displacement position, the staple pushing surface of the staple pushing piece is flush with the staple cartridge surface or lower than the staple cartridge surface.

Abstract: A computing system may include an eject direction determination engine configured to determine an eject direction for an injection mold design, including by determining a set of candidate eject directions for the injection mold design, including a bounding box candidate eject direction determined based on a minimum bounding box of an object representative of a product to be manufactured through the injection mold design and selecting the eject direction for the injection mold design from the set of candidate eject directions based on eject direction determination criteria. The computing system may also include an eject direction application engine configured to set the determined eject direction for the injection mold design so that physical mold pieces constructed from the injection mold design are configured to separate from one another in the determined eject direction during an injection mold production process to manufacture the product.

Abstract: A surgical instrument, including an openable/closable staple cartridge and a staple anvil. The staple cartridge has a staple cartridge surface facing the staple anvil (200). The staple cartridge is further provided with a staple recess extending in a direction perpendicular to the staple cartridge surface. A staple and a staple pushing piece are accommodated in the staple recess. The staple pushing piece is arranged at the side of the staple away from the staple cartridge surface, and the staple pushing piece is provided with a staple pushing surface used for contacting the staple so as to push the staple. The staple cartridge is configured such that when the staple pushing piece pushes the staple towards the staple anvil to move to a maximum displacement position, the staple pushing surface of the staple pushing piece is flush with the staple cartridge surface or lower than the staple cartridge surface.

Abstract: A multi-target kinase inhibitor is shown in formula (I), in which R is selected from formula (a), formula (b), formula (c), formula (d), formula (e) and formula (f). The multi-target kinase inhibitor can effectively inhibit the enzymatic activities of RET, VEGFR3 and PDGFRA, and can effectively treat diseases that are regulated and controlled by multi-target kinases and are related to abnormal signal transduction pathways of the multi-target kinases, including cancers of breast, respiratory tract, brain, reproductive organ, digestive tract, urinary tract, eye, liver, skin, head and/or neck and distant metastatic cancers thereof, and lymphoma, sarcoma, leukemia and the like. The active ingredients of the pharmaceutical composition of the present invention comprise a multi-target kinase inhibitor, which accounts for 1-50 wt % of the composition.

Abstract: A clip applying mechanism and a clip applying apparatus thereof are provided. The clip applying mechanism includes a tube body, a main shaft, a clip-cartridge assembly, a clip-pushing assembly and a firing assembly; and further includes: a main-shaft connecting member, connected with the main shaft; a firing connecting member, connected with the firing assembly; an engagement mechanism, arranged between the main-shaft connecting member and the firing connecting member. The engagement mechanism, the firing connecting member, the main-shaft connecting member and the firing assembly are configured such that: in a case where the clip is fired, the main-shaft connecting member drives the firing connecting member to move in a direction facing away from the head end of the tube body through the engagement mechanism, and the firing connecting member drives the firing assembly to move in a same direction, so that the end effector is partially opened.

Abstract: A clip applying mechanism and a clip applying apparatus thereof are provided. The clip applying mechanism includes a tube body, a main shaft, a clip-cartridge assembly and a clip-pushing assembly; and further includes: a main-shaft connecting member, sleeved on the main shaft and connected with the main shaft; the main-shaft connecting member being configured to move in a same direction as the main shaft in an axial direction of the tube body; a housing, configured to accommodate the main shaft and the main-shaft connecting member; and a locking mechanism, arranged between the main-shaft connecting member and the housing; in a case that the clip is conveyed into the end effector, the main-shaft connecting member and the housing are locked with each other through the locking mechanism.

Abstract: A clip applying mechanism and a clip applying apparatus thereof. The clip applying mechanism includes a tube body, a main shaft, a clip-cartridge assembly, a clip-pushing assembly and a firing assembly; and further includes: a main-shaft connecting member, sleeved on the main shaft and connected with the main shaft; a housing, configured to accommodate the main shaft and the main-shaft connecting member, the main-shaft connecting member being configured to be capable of moving relative to the housing in an axial direction of the tube body and in a circumferential direction of the tube body; a limiting mechanism, arranged between the main-shaft connecting member and the housing, the limiting mechanism being configured to limit a movement range of the main-shaft connecting member relative to the housing.

Abstract: A clip applying mechanism and a clip applying apparatus thereof are provided. The clip applying mechanism includes a tube body, a main shaft, a clip-cartridge assembly, a clip-pushing assembly and a firing assembly; and further includes: a main-shaft connecting member, sleeved on the main shaft and connected with the main shaft; a housing, configured to accommodate the main shaft and the main-shaft connecting member, the main-shaft connecting member being configured to move relative to the housing in an axial direction of the tube body and in a circumferential direction of the tube body; a first guiding mechanism, arranged between the main-shaft connecting member and the housing, the first guiding mechanism being configured to guide the main-shaft connecting member to move relative to the housing.

Abstract: A multi-target kinase inhibitor is shown in formula (I), in which R is selected from formula (a), formula (b), formula (c), formula (d), formula (e) and formula (f). The multi-target kinase inhibitor can effectively inhibit the enzymatic activities of RET, VEGFR3 and PDGFRA, and can effectively treat diseases that are regulated and controlled by multi-target kinases and are related to abnormal signal transduction pathways of the multi-target kinases, including cancers of breast, respiratory tract, brain, reproductive organ, digestive tract, urinary tract, eye, liver, skin, head and/or neck and distant metastatic cancers thereof, and lymphoma, sarcoma, leukemia and the like. The active ingredients of the pharmaceutical composition of the present invention comprise a multi-target kinase inhibitor, which accounts for 1-50 wt % of the composition.

Abstract: The present invention relates to microbiology technology field. More particularly, it relates to Pseudomonas alcaliphila MBR CGMCC 2318 which has the ability to reduce and adsorb metal and nonmetal ions. It also relates to methods of bioreduction and biosorption using the said strain by means of its property of reducing nitrate to ammonium and adsorbing metal ions to reduce the metal and nonmetal ions in the solution to elementary state under aerobic conditions. The present invention also relates to application of the said strain in bio-metallurgy, production of metal and nonmetal elementary substance, treatment of wastewater containing metal ions, and removal of harmful metal and nonmetal ions contained in soil and water. The strain of the present invention is easy to cultivate. The method of bioreduction and biosorption by it is very simple and can be widely used in metallurgy, treatment of wastewater and removal of harmful substances in soil and water.

Abstract: The present invention relates to microbiology technology field. More particularly, it relates to Pseudomonas alcaliphila MBR CGMCC 2318 which has the ability to reduce and adsorb metal and nonmetal ions. It also relates to methods of bioreduction and biosorption using the said strain by means of its property of reducing nitrate to ammonium and adsorbing metal ions to reduce the metal and nonmetal ions in the solution to elementary state under aerobic conditions. The present invention also relates to application of the said strain in bio-metallurgy, production of metal and nonmetal elementary substance, treatment of wastewater containing metal ions, and removal of harmful metal and nonmetal ions contained in soil and water. The strain of the present invention is easy to cultivate. The method of bioreduction and biosorption by it is very simple and can be widely used in metallurgy, treatment of wastewater and removal of harmful substances in soil and water.