Abstract: Contained herein is a system and method for using non-contact diffuse optical skin reflectance method to obtain remote sensing of in-vivo glucose levels in biological tissue or fluids. One embodiment uses an optical, non-contact method capable of measuring glucose levels at a stand-off distance of 0.5 to 2 meters. In this method, the tissue is illuminated with a collimated beam of near-infrared (optical) band of light having a specific band of wavelengths. The diffuse reflectance measured from the tissue/fluid is collected while varying the optical circuit. Using the collected data, an algorithm to unravel the mixed effects of tissue/fluid scattering and absorption is applied to determine the absorption level of the light, which is then associated with a quantitative glucose level.

Abstract: This invention is regarding a set of stand-alone or combined-use surgical tools and associated systems and methods for performing surgical procedures such as identifying hidden tissue anatomy and dissecting the periphery tissues. In particular, this invention describes tools and the associated systems and methods for visualizing hidden important structures such as arteries, veins, ureters, bile duct, bowel, nodules, tumors, and performing tissue cutting using energy-based instrument. The tools are to be operated stand-alone or by attaching to existing instruments used for minimally invasive surgery.

Abstract: Contained herein is a system and method for using non-contact diffuse optical skin reflectance method to obtain remote sensing of in-vivo glucose levels in biological tissue or fluids. One embodiment uses an optical, non-contact method capable of measuring glucose levels at a stand-off distance of 0.5 to 2 meters. In this method, the tissue is illuminated with a collimated beam of near-infrared (optical) band of light having a specific band of wavelengths. The diffuse reflectance measured from the tissue/fluid is collected while varying the optical circuit. Using the collected data, an algorithm to unravel the mixed effects of tissue/fluid scattering and absorption is applied to determine the absorption level of the light, which is then associated with a quantitative glucose level.

Abstract: Taught herein is a new contact-based optical imaging technology, en-face differential optical topography (en-face DOT), which performs real-time visualization of subsurface tissue heterogeneity within a depth up to 3 mm and over a 9.5 mm diameter FOV with a modest mm-level lateral resolution. An embodiment of the probe fits in a 12 mm port and houses at its maximum 128 cop-per-coated 750 ?m fibers that form radially alternating illumination (70 fibers) and detection (58 fibers) channels. By simultaneously illuminating the 70 source channels of the laparoscopic probe that is in contact with a scattering medium and concurrently measuring the light diffusely propagated to the 58 detector channels, the presence of near-surface optical heterogeneities can be resolved in an en-face 9.5 mm field-of-view in real-time. Visualization of subsurface margin of strong attenuation contrast at a depth up to 3 mm is demonstrated at one wavelength at a frame rate of 1.3 Hz.

Abstract: This invention is regarding a set of stand-alone or combined-use surgical tools and associated systems and methods for performing surgical procedures such as identifying hidden tissue anatomy and dissecting the periphery tissues. In particular, this invention describes tools and the associated systems and methods for visualizing hidden important structures such as arteries, veins, ureters, bile duct, bowel, nodules, tumors, and performing tissue cutting using energy-based instrument. The tools are to be operated stand-alone or by attaching to existing instruments used for minimally invasive surgery.

Abstract: A method includes providing a pulsed magnetic field, exposing a tissue mass to the pulsed magnetic field, and receiving an ultrasonic signal from a region of the tissue imbued with magnetic particles.

Abstract: Optical tomography systems that provide light of multiple distinct wavelengths from a plurality of sources are described. The systems direct light into mammalian tissue, and light from the mammalian tissue is collected at a plurality of reception points. Collected light from each reception point is separated according to its wavelength, and received by a photodetector to produce path attenuation signals representing attenuation along paths between the source locations and the reception points. An image construction system generates a tomographic image of the mammalian tissue from the path attenuation signals. One embodiment of an optical imaging system includes an optical coherence tomography-near infrared probe. The systems and methods may utilize a spectral derivative approach that provides insensitivity to the boundary and boundary artifacts in the signal, thereby improving the quality of the reconstructed images.

Abstract: An optical tomography system has a group of lasers for generating light of multiple distinct wavelengths within a first wavelength band. Light from these lasers is directed into mammalian tissue at laser-specific locations on the tissue, and light from the mammalian tissue is collected at a plurality of reception points. Collected light from each reception point is separated according to its wavelength, and received by a photodetector to produce path attenuation signals representing attenuation along paths between the laser-specific locations on the tissue and the reception points. Image construction apparatus generates a tomographic image of heme concentrations in the mammalian tissue from the path attenuation signals. In an alternative embodiment, there is a second group of lasers operating in a second wavelength band, and the image construction apparatus can generate an image of heme oxygenation In the mammalian tissue.

Abstract: Optical tomography systems that provide light of multiple distinct wavelengths from a plurality of sources are described. The systems direct light into mammalian tissue, and light from the mammalian tissue is collected at a plurality of reception points. Collected light from each reception point is separated according to its wavelength, and received by a photodetector to produce path attenuation signals representing attenuation along paths between the source locations and the reception points. An image construction system generates a tomographic image of the mammalian tissue from the path attenuation signals. One embodiment of an optical imaging system includes an optical coherence tomography-near infrared probe. The systems and methods may utilize a spectral derivative approach that provides insensitivity to the boundary and boundary artifacts in the signal, thereby improving the quality of the reconstructed images.

Abstract: An optical tomography system has a group of lasers for generating light of multiple distinct wavelengths within a first wavelength band. Light from these lasers is directed into mammalian tissue at laser-specific locations on the tissue, and light from the mammalian tissue is collected at a plurality of reception points. Collected light from each reception point is separated according to its wavelength, and received by a photodetector to produce path attenuation signals representing attenuation along paths between the laser-specific locations on the tissue and the reception points. Image construction apparatus generates a tomographic image of heme concentrations in the mammalian tissue from the path attenuation signals. In an alternative embodiment, there is a second group of lasers operating in a second wavelength band, and the image construction apparatus can generate an image of heme oxygenation In the mammalian tissue.