Patents by Inventor Darcy MADDEN

Darcy MADDEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nitrilases, nucleic acids encoding them and methods for making and using them
    Patent number: 9217164
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: December 22, 2015
    Assignee: BASF Enzymes LLC
    Inventors: Jennifer A. Chaplin, Ellen Chi, Grace DeSantis, Mark Madden, Darcy Madden, Aileen Milan, Dan E. Robertson, Jay M. Short, David P. Weiner
  • Nitrilases and methods for making and using them
    Patent number: 8501451
    Abstract: The invention provides nitrilases and methods for making and using them, and in one aspect, provides methods for producing enantiomerically pure ?-substituted carboxylic acids, such as, for example, ?-amino acids and ?-hydroxy acids. In one aspect, methods of the invention combine an aldehyde or ketone with a cyanide and ammonia or an ammonium salt or an amine, in the presence of a nitrilase or a polypeptide having nitrilase activity, to stereoselectively hydrolyze the amino nitrile or cyanohydrin intermediate under conditions sufficient to produce the carboxylic acid.
    Type: Grant
    Filed: September 21, 2011
    Date of Patent: August 6, 2013
    Assignee: Verenium Corporation
    Inventors: David Paul Weiner, Jennifer Ann Chaplin, Dan E. Robertson, Darcy Madden
  • NITRILASES
    Publication number: 20130177949
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: November 16, 2012
    Publication date: July 11, 2013
    Applicant: VERENIUM CORPORATION
    Inventors: VERENIUM CORPORATION, Darcy Madden
  • Nucleic acids encoding nitrilases
    Patent number: 8334125
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: December 18, 2012
    Assignee: Verenium Corporation
    Inventors: Grace DeSantis, Ellen Chi, Jennifer Ann Chaplin, Aileen Milan, Jay Short, David Weiner, Mark Madden, Darcy Madden, legal representative, Mark Burk, Dan Robertson
  • NITRILASES AND METHODS FOR MAKING AND USING THEM
    Publication number: 20120009633
    Abstract: The invention provides nitrilases and methods for making and using them, and in one aspect, provides methods for producing enantiomerically pure ?-substituted carboxylic acids, such as, for example, ?-amino acids and ?-hydroxy acids. In one aspect, methods of the invention combine an aldehyde or ketone with a cyanide and ammonia or an ammonium salt or an amine, in the presence of a nitrilase or a polypeptide having nitrilase activity, to stereoselectively hydrolyze the amino nitrile or cyanohydrin intermediate under conditions sufficient to produce the carboxylic acid.
    Type: Application
    Filed: September 21, 2011
    Publication date: January 12, 2012
    Applicant: Verenium Corporation
    Inventors: Mark Madden, DARCY MADDEN, David Paul Weiner, Jennifer Ann Chaplin, Dan E. Robertson
  • Nucleic Acids Encoding Nitrilases
    Publication number: 20110263839
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: June 27, 2011
    Publication date: October 27, 2011
    Applicant: VERENIUM CORPORATION
    Inventors: Grace DESANTIS, Jennifer Ann CHAPLIN, Ellen CHI, Aileen MILAN, Jay M. SHORT, David WEINER, Mark MADDEN, Darcy MADDEN, Mark J. BURK, Dan E. ROBERTSON
  • Nitrilases, Nucleic Acids Encoding Them and Methods for Making and Using Them
    Publication number: 20100273659
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: February 29, 2008
    Publication date: October 28, 2010
    Applicant: VERENIUM CORPORATION
    Inventors: Grace DeSantis, Jennifer Chaplin, Ellen Chi, Aileen Milan, Jay Short, David Weiner, Mark Madden, Darcy Madden, Dan Robertson
  • Nitrilases and Methods for Making and Using Them
    Publication number: 20100086986
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: December 2, 2009
    Publication date: April 8, 2010
    Applicant: VERENIUM CORPORATION
    Inventors: Grace DESANTIS, Jennifer Ann CHAPLIN, Ellen CHI, Aileen MILAN, Jay M. SHORT, David WEINER, Mark MADDEN, Darcy MADDEN, Mark J. BURK, Dan E. ROBERTSON
  • Nitrilases
    Patent number: 7651849
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Grant
    Filed: March 3, 2009
    Date of Patent: January 26, 2010
    Inventors: Grace DeSantis, Ellen Chi, Jennifer Ann Chaplin, Aileen Milan, Jay M. Short, David Paul Weiner, Mark Madden, Darcy Madden, legal representative, Mark J. Burk, Dan E. Robertson
  • NITRILASES
    Publication number: 20090176976
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: March 3, 2009
    Publication date: July 9, 2009
    Inventors: Grace DESANTIS, Jennifer Ann Chaplin, Ellen Chi, Aileen Milan, Jay M. Short, David Weiner, Mark Madden, Mark J. Burk, Dan E. Robertson, Darcy Madden
  • Nitrilases and methods for making and using them
    Patent number: 7521216
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: April 21, 2009
    Assignee: Verenium Corporation
    Inventors: Grace DeSantis, Jennifer Ann Chaplin, Ellen Chi, Aileen Milan, Jay M. Short, David Weiner, Darcy Madden, legal representative, Mark J. Burk, Dan E. Robertson, Mark Madden
  • Methods for producing ?-substituted carboxylic acids using nitrilases and strecker reagents
    Patent number: 7300775
    Abstract: In accordance with the present invention there are provided methods for producing enantiomerically pure ?-substituted carboxylic acids, such as, for example, ?-amino acids and ?-hydroxy acids, said method comprising combining an aldehyde or ketone with a cyanide and ammonia or an anmionium salt or an amine, in the presence of a nitrilase or a polypeptide having nitrilase activity which stereoselectively hydrolyzes the amino nitrile or cyanohydrin intermediate under conditions sufficient to produce the enantiomerically pure ?-substituted carboxylic acid, such as, for example, ?-amino acids and ?-hydroxy acids.
    Type: Grant
    Filed: December 28, 2000
    Date of Patent: November 27, 2007
    Assignee: Verenium Corporation
    Inventors: Darcy Madden, legal representative, David Paul Weiner, Jennifer Ann Chaplin, Dan E. Robertson, Mark Madden, deceased
  • Nitrilases
    Publication number: 20040002147
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: September 9, 2002
    Publication date: January 1, 2004
    Inventors: Grace Desantis, Jennifer Ann Chaplin, Ellen Chi, Aileen Milan, Jay M. Short, David Weiner, Mark J. Burk, Eric J. Mathur, Darcy Madden (Heir)
  • Nitrilases
    Publication number: 20030124698
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: May 15, 2002
    Publication date: July 3, 2003
    Applicant: DIVERSA Corporation
    Inventors: Grace DeSantis, Jennifer Ann Chaplin, Ellen Chi, Aileen Milan, Jay M. Short, David Weiner, Mark Maddes, Darcy Madden, Mark J. Burk, Eric Mathur