Patents by Inventor Da-Ren Chen
Da-Ren Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9642694Abstract: Devices to deliver one or more active ingredients for medical treatment may include a body of material presenting a surface including a polymer adapted to be rendered conductive such that one or more layers of electrospray particles are formable thereon or a body of conductive material presenting a surface upon which one or more layers of electrospray particles are formable thereon. A coating formed of electrospray particles may be deposited to adhere on the surface of the body of material (e.g., the coating may include one or more layers of coating material, at least one layer of the one or more layers of coating material may include an open matrix coating, the open matrix coating may include one or more active ingredients, the open matrix coating may include one or more polymers and one or more active ingredients, etc.).Type: GrantFiled: December 22, 2014Date of Patent: May 9, 2017Assignees: REGENTS OF THE UNIVERSITY OF MINNESOTA, NANOCOPOEIA, INC.Inventors: Robert A. Hoerr, Da-Ren Chen, John V. Carlson, David Y. H. Pui
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Publication number: 20150352592Abstract: Devices to deliver one or more active ingredients for medical treatment may include a body of material presenting a surface including a polymer adapted to be rendered conductive such that one or more layers of electrospray particles are formable thereon or a body of conductive material presenting a surface upon which one or more layers of electrospray particles are formable thereon. A coating formed of electrospray particles may be deposited to adhere on the surface of the body of material (e.g., the coating may include one or more layers of coating material, at least one layer of the one or more layers of coating material may include an open matrix coating, the open matrix coating may include one or more active ingredients, the open matrix coating may include one or more polymers and one or more active ingredients, etc.).Type: ApplicationFiled: December 22, 2014Publication date: December 10, 2015Inventors: ROBERT A. HOERR, DA-REN CHEN, JOHN V. CARLSON, DAVID Y.H. PUI
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Patent number: 9050611Abstract: Spraying apparatus and methods that employ multiple nozzle structures for producing multiple sprays of particles, e.g., nanoparticles, for various applications, e.g., pharmaceuticals, are provided. For example, an electrospray dispensing device may include a plurality of nozzle structures, wherein each nozzle structure is separated from adjacent nozzle structures by an internozzle distance. Sprays of particles are established from the nozzle structures by creating a nonuniform electrical field between the nozzle structures and an electrode electrically isolated therefrom.Type: GrantFiled: February 15, 2013Date of Patent: June 9, 2015Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: David Y. H. Pui, Da-Ren Chen
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Patent number: 8704155Abstract: Detection of individual objects using a light source and a whispering gallery mode (WGM) resonator. Light from the whispering gallery mode (WGM) resonator is analyzed. The presence of an object is determined based on mode splitting associated with the light received by the photodetector. For example, the presence of the object may be determined based on the distance between two whispering gallery modes and/or the linewidths of the two modes in a transmission spectrum. Alternatively, the presence of the object may be determined based on a beat frequency that is determined based on a heterodyne beat signal produced by combining split laser modes in the received light from a WGM microcavity laser.Type: GrantFiled: December 13, 2010Date of Patent: April 22, 2014Assignee: Washington UniversityInventors: Lina He, Jiangang Zhu, Sahin Kaya Ozdemir, Lan Yang, Da-Ren Chen
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Publication number: 20130323403Abstract: Electrospray methods and systems for coating of objects (e.g., medical devices such as a stent structure) with selected types of coatings (e.g., open matrix coating and closed film coating).Type: ApplicationFiled: May 24, 2013Publication date: December 5, 2013Applicants: REGENTS OF THE UNIVERSITY OF MINNESOTA, NANOCOPOEIA, INC.Inventors: ROBERT A. HOERR, DA-REN CHEN, JOHN V. CARLSON, DAVID Y.H. PUI
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Patent number: 8044350Abstract: An apparatus for measuring particle size distribution includes a charging device and a precipitator. The charging device includes a corona that generates charged ions in response to a first applied voltage, and a charger body that generates a low energy electrical field in response to a second applied voltage in order to channel the charged ions out of the charging device. The corona tip and the charger body are arranged relative to each other to direct a flow of particles through the low energy electrical field in a direction parallel to a direction in which the charged ions are channeled out of the charging device. The precipitator receives the plurality of particles from the charging device, and includes a disk having a top surface and an opposite bottom surface, wherein a predetermined voltage is applied to the top surface and the bottom surface to precipitate the plurality of particles.Type: GrantFiled: December 1, 2008Date of Patent: October 25, 2011Assignee: Washington UniversityInventors: Da-Ren Chen, Chaolong Qi
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Patent number: 8028646Abstract: Methods and systems for coating at least a portion of a medical device (e.g., a stent structure) include providing a plurality of coating particles (e.g., monodisperse coating particles) in a defined volume. For example, the particles may be provided using one or more nozzle structures, wherein each nozzle structure includes at least one opening terminating at a dispensing end. The plurality of coating particles may be provided in the defined volume by dispensing a plurality of microdroplets having an electrical charge associated therewith from the dispensing ends of the one or more nozzle structures through use of a nonuniform electrical field between the dispensing ends and the medical device. Electrical charge is concentrated on the particle as the microdroplet evaporates. With a plurality of coating particles provided in the defined volume, such particles can be moved towards at least one surface of the medical device to form a coating thereon (e.g.Type: GrantFiled: March 28, 2006Date of Patent: October 4, 2011Assignee: Regents of the University of MinnesotaInventors: David Y. H. Pui, Da-Ren Chen
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Publication number: 20110229627Abstract: Electrospray methods and systems for coating of objects (e.g., medical devices such as a stent structure) with selected types of coatings (e.g.Type: ApplicationFiled: May 27, 2011Publication date: September 22, 2011Applicants: NANOCOPOEIA, INC., Regents of the University of MinnesotaInventors: ROBERT A. HOERR, JOHN V. CARLSON, DA-REN CHEN, DAVID Y.H. PUI
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Publication number: 20110174902Abstract: Spraying apparatus and methods that employ multiple nozzle structures for producing multiple sprays of particles, e.g., nanoparticles, for various applications, e.g., pharmaceuticals, are provided. For example, an electrospray dispensing device may include a plurality of nozzle structures, wherein each nozzle structure is separated from adjacent nozzle structures by an interozzle distance. Sprays of particles are established from the nozzle structures by creating a nonuniform electrical field between the nozzle structures and an electrode electrically isolated therefrom.Type: ApplicationFiled: March 29, 2011Publication date: July 21, 2011Applicant: Regents of the University of MinnesotaInventors: David Y.H. Pui, Da-Ren Chen
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Patent number: 7972661Abstract: An electrospraying apparatus and/or method is used to coat particles. For example, a flow including at least one liquid suspension may be provided through at least one opening at a spray dispenser end. The flow includes at least particles and a coating material. A spray of microdroplets suspending at least the particles is established forward of the spray dispenser end by creating a nonuniform electrical field between the spray dispenser end and an electrode electrically isolated therefrom. The particles are coated with at least a portion of the coating material as the microdroplet evaporates. For example, the suspension may include biological material particles.Type: GrantFiled: October 4, 2007Date of Patent: July 5, 2011Assignee: Regents of the University of MinnesotaInventors: David Y. H. Pui, Da-Ren Chen
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Publication number: 20110139970Abstract: Detection of individual objects using a light source and a whispering gallery mode (WGM) resonator. Light from the whispering gallery mode (WGM) resonator is analyzed. The presence of an object is determined based on mode splitting associated with the light received by the photodetector. For example, the presence of the object may be determined based on the distance between two whispering gallery modes and/or the linewidths of the two modes in a transmission spectrum. Alternatively, the presence of the object may be determined based on a beat frequency that is determined based on a heterodyne beat signal produced by combining split laser modes in the received light from a WGM microcavity laser.Type: ApplicationFiled: December 13, 2010Publication date: June 16, 2011Applicant: WASHINGTON UNIVERSITY IN ST. LOUISInventors: Lina He, Jiangang Zhu, Sahin Kaya Ozdemir, Lan Yang, Da-Ren Chen
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Patent number: 7951428Abstract: Electrospray methods and systems for coating of objects (e.g., medical devices such as a stent structure) with an open matrix coating. The open matrix coating is formed by electrospray using one or more nozzle structures each having at least an inner and outer opening. A first flow of a liquid spray composition is provided to the inner opening and a second flow of a liquid diluent composition is provided to the outer opening (e.g., the liquid diluent composition including at least one solvent, such as a composition having a dielectric constant equal to or greater than 10).Type: GrantFiled: January 31, 2007Date of Patent: May 31, 2011Assignee: Regents of the University of MinnesotaInventors: Robert A. Hoerr, John V. Carlson, Da-Ren Chen, David Y. H. Pui
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Publication number: 20100001184Abstract: An apparatus for measuring particle size distribution includes a charging device and a precipitator. The charging device includes a corona that generates charged ions in response to a first applied voltage, and a charger body that generates a low energy electrical field in response to a second applied voltage in order to channel the charged ions out of the charging device. The corona tip and the charger body are arranged relative to each other to direct a flow of particles through the low energy electrical field in a direction parallel to a direction in which the charged ions are channeled out of the charging device. The precipitator receives the plurality of particles from the charging device, and includes a disk having a top surface and an opposite bottom surface, wherein a predetermined voltage is applied to the top surface and the bottom surface to precipitate the plurality of particles.Type: ApplicationFiled: December 1, 2008Publication date: January 7, 2010Applicant: Washington University in St. LouisInventors: Da-Ren Chen, Chaolong Qi
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Publication number: 20090266924Abstract: Spraying apparatus and methods that employ multiple nozzle structures for producing multiple sprays of particles, e.g., nanoparticles, for various applications, e.g., pharmaceuticals, are provided. For example, an electrospray dispensing device may include a plurality of nozzle structures, wherein each nozzle structure is separated from adjacent nozzle structures by an internozzle distance. Sprays of particles are established from the nozzle structures by creating a nonuniform electrical field between the nozzle structures and an electrode electrically isolated therefrom.Type: ApplicationFiled: February 27, 2009Publication date: October 29, 2009Applicant: Regents of the University of MinnesotaInventors: David Y.H. Pui, Da-Ren Chen
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Patent number: 7498063Abstract: Spraying apparatus and methods that employ multiple nozzle structures for producing multiple sprays of particles, e.g., nanoparticles, for various applications, e.g., pharmaceuticals, are provided. For example, an electrospray dispensing device may include a plurality of nozzle structures, wherein each nozzle structure is separated from adjacent nozzle structures by an internozzle distance. Sprays of particles are established from the nozzle structures by creating a nonuniform electrical field between the nozzle structures and an electrode electrically isolated therefrom.Type: GrantFiled: July 12, 2004Date of Patent: March 3, 2009Assignee: Regents of the University of MinnesotaInventors: David Y. H. Pui, Da-Ren Chen
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Publication number: 20080141936Abstract: An electrospraying apparatus and/or method is used to coat particles. For example, a flow including at least one liquid suspension may be provided through at least one opening at a spray dispenser end. The flow includes at least particles and a coating material. A spray of microdroplets suspending at least the particles is established forward of the spray dispenser end by creating a nonuniform electrical field between the spray dispenser end and an electrode electrically isolated therefrom. The particles are coated with at least a portion of the coating material as the microdroplet evaporates. For example, the suspension may include biological material particles.Type: ApplicationFiled: October 4, 2007Publication date: June 19, 2008Applicant: Regents of the University of MinnesotaInventors: David Y.H. Pui, Da-Ren Chen
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Patent number: 7279322Abstract: An electrospraying apparatus and/or method is used to coat particles. For example, a flow including at least one liquid suspension may be provided through at least one opening at a spray dispenser end. The flow includes at least particles and a coating material. A spray of microdroplets suspending at least the particles is established forward of the spray dispenser end by creating a nonuniform electrical field between the spray dispenser end and an electrode electrically isolated therefrom. The particles are coated with at least a portion of the coating material as the microdroplet evaporates. For example, the suspension may include biological material particles.Type: GrantFiled: March 25, 2004Date of Patent: October 9, 2007Assignee: Regents of the University of MinnesotaInventors: David Y. H. Pui, Da-Ren Chen
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Publication number: 20070199824Abstract: Electrospray methods and systems for coating of objects (e.g., medical devices such as a stent structure) with selected types of coatings (e.g.Type: ApplicationFiled: January 31, 2007Publication date: August 30, 2007Inventors: Robert Hoerr, John Carlson, Da-Ren Chen, David Pui
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Patent number: 7247338Abstract: Methods and systems for coating at least a portion of a medical device (e.g., a stent structure) include providing a plurality of coating particles (e.g., monodisperse coating particles) in a defined volume. For example, the particles may be provided using one or more nozzle structures, wherein each nozzle structure includes at least one opening terminating at a dispensing end. The plurality of coating particles may be provided in the defined volume by dispensing a plurality of microdroplets having an electrical charge associated therewith from the dispensing ends of the one or more nozzle structures through use of a nonuniform electrical field between the dispensing ends and the medical device. Electrical charge is concentrated on the particle as the microdroplet evaporates. With a plurality of coating particles provided in the defined volume, such particles can be moved towards at least one surface of the medical device to form a coating thereon (e.g.Type: GrantFiled: November 21, 2002Date of Patent: July 24, 2007Assignee: Regents of the University of MinnesotaInventors: David Y. H. Pui, Da-Ren Chen
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Patent number: 7213476Abstract: A multi-stage differential mobility analyzer (MDMA) for aerosol measurements includes a first electrode or grid including at least one inlet or injection slit for receiving an aerosol including charged particles for analysis. A second electrode or grid is spaced apart from the first electrode. The second electrode has at least one sampling outlet disposed at a plurality different distances along its length. A volume between the first and the second electrode or grid between the inlet or injection slit and a distal one of the plurality of sampling outlets forms a classifying region, the first and second electrodes for charging to suitable potentials to create an electric field within the classifying region. At least one inlet or injection slit in the second electrode receives a sheath gas flow into an upstream end of the classifying region, wherein each sampling outlet functions as an independent DMA stage and classifies different size ranges of charged particles based on electric mobility simultaneously.Type: GrantFiled: September 30, 2005Date of Patent: May 8, 2007Assignee: UT-Battelle, LLCInventors: Meng-Dawn Cheng, Da-Ren Chen