Patents by Inventor Darian Cash

Darian Cash has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treatment using adiponectin variants
    Patent number: 7749956
    Abstract: A method of treating a mammal with an adiponectin mediated disorder comprising administering a therapeutically effective amount of an adiponectin variant with at least a 3-fold increased solubility relative to residues 110-244 of human adiponectin.
    Type: Grant
    Filed: May 30, 2006
    Date of Patent: July 6, 2010
    Assignee: Xencor, Inc.
    Inventors: Jonathan Zalevsky, Duc-Hanh Thi Nguyen, Gregory L. Moore, Sergei A. Ezhevsky, John R. Desjarlais, Arthur J. Chirino, Darian Cash, Matthew J. Bernett
  • Adiponectin variants
    Patent number: 7709607
    Abstract: An adiponectin variant with one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the solubility of the variant is improved by at least 3-fold relative to residues 110-244 of human adiponectin.
    Type: Grant
    Filed: May 30, 2006
    Date of Patent: May 4, 2010
    Assignee: Xencor, Inc.
    Inventors: Jonathan Zalevsky, Duc-Hanh Thi Nguyen, Gregory L. Moore, Sergei A. Ezhevsky, John R. Desjarlais, Arthur J. Chirino, Darian Cash, Matthew J. Bernett
  • Pharmaceutical compositions of adiponectin variants and methods of storage
    Patent number: 7678886
    Abstract: A composition comprising an adiponectin variant at a concentration of at least 2.0 mg/mL, and a pharmaceutically acceptable carrier, wherein less than 20% of said adiponectin variant would aggregate after storage at 4° C. for one week in 10 mM PO4, 150 mM NaCl buffer.
    Type: Grant
    Filed: May 30, 2006
    Date of Patent: March 16, 2010
    Assignee: Xencor, Inc.
    Inventors: Jonathan Zalevsky, Duc-Hanh Thi Nguyen, Gregory L. Moore, Sergei A. Ezhevsky, John R. Desjarlais, Arthur J. Chirino, Darian Cash, Matthew J. Bernett
  • Globular adiponectin variants
    Patent number: 7592423
    Abstract: An adiponectin variant with one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the adiponectin variant is not glycosylated, the adiponectin variant does not have residues 1-100 relative to human adiponectin, and wherein the solubility of the variant is improved by at least 3-fold relative to residues 110-244 of human adiponectin.
    Type: Grant
    Filed: May 30, 2006
    Date of Patent: September 22, 2009
    Assignee: Xencor, Inc.
    Inventors: Jonathan Zalevsky, Duc-Hanh Thi Nguyen, Gregory L. Moore, Sergei A. Ezhevsky, John R. Desjarlais, Arthur J. Chirino, Darian Cash, Matthew J. Bernett
  • Rational Chemical Modification of Adiponectin Variants
    Publication number: 20070054359
    Abstract: An adiponectin variant with at least a 3-fold increased solubility relative to residues 110-244 of human adiponectin, wherein the adiponectin variant has at least one covalently attached non-peptide moiety at at least one position selected from the group consisting of: A108, Y109, S146, D179, E220, R221, and L224, relative to human adiponectin
    Type: Application
    Filed: May 30, 2006
    Publication date: March 8, 2007
    Inventors: Jonathan Zalevsky, Duc-Hanh Nguyen, Gregory Moore, Sergei Ezhevsky, John Desjarlais, Arthur Chirino, Darian Cash, Matthew Bernett
  • Adiponectin variants
    Publication number: 20070015909
    Abstract: Adiponectin variants comprising one or more amino acid modifications to corresponding wild-type adiponectins at positions having predetermined hydrophobicity, predetermined polarity, predetermined electrostatic potential, Met, aromatic amino acid, Cys corresponding to position 152 of SEQ ID NO:1, amino acid affecting isoelectric point of the wild-type or variant adiponectin, amino acid affecting beta sheet formation, helix capping, or dipole interactions, or a combination thereof, wherein the adiponectin variants exhibit improved stability, solubility or soluble expression, expression yield, the ability to induce phosphorylation of AMPK, or a combination thereof, as compared to the corresponding wild-type adiponectins.
    Type: Application
    Filed: January 9, 2006
    Publication date: January 18, 2007
    Inventors: Darian Cash, Arthur Chirino, John Desjarlais, Sergei Ezhevsky, Gregory Moore, Duc-Hahn Nguyen, Jonathan Zalevsky
  • Adiponectin variants
    Publication number: 20070010659
    Abstract: An adiponectin variant with one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the solubility of the variant is improved by at least 3-fold relative to residues 110-244 of human adiponectin.
    Type: Application
    Filed: May 30, 2006
    Publication date: January 11, 2007
    Inventors: Jonathan Zalevsky, Duc-Hanh Nguyen, Gregory Moore, Sergei Ezhevsky, John Desjarlais, Arthur Chirino, Darian Cash, Matthew Bernett
  • Globular Adiponectin Variants
    Publication number: 20060281151
    Abstract: An adiponectin variant with one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the adiponectin variant is not glycosylated, the adiponectin variant does not have residues 1-100 relative to human adiponectin, and wherein the solubility of the variant is improved by at least 3-fold relative to residues 110-244 of human adiponectin.
    Type: Application
    Filed: May 30, 2006
    Publication date: December 14, 2006
    Inventors: Jonathan Zalevsky, Duc-Hanh Nguyen, Gregory Moore, Sergei Ezhevsky, John Desjarlais, Arthur Chirino, Darian Cash, Matthew Bernett
  • Pharmaceutical Compositions of Adiponectin Variants and Methods of Storage
    Publication number: 20060276395
    Abstract: 1. A composition comprising an adiponectin variant at a concentration of at least 2.0 mg/mL, and a pharmaceutically acceptable carrier, wherein less than 20% of said adiponectin variant would aggregate after storage at 4° C. for one week in 10 mM PO4, 150 mM NaCl buffer.
    Type: Application
    Filed: May 30, 2006
    Publication date: December 7, 2006
    Inventors: Jonathan Zalevsky, Duc-Hanh Thi Nguyen, Gregory Moore, Sergei Ezhevsky, John Desjarlais, Arthur Chirino, Darian Cash, Matthew Bernett
  • Method of Treatment Using Adiponectin Variants
    Publication number: 20060270598
    Abstract: A method of treating a mammal with an adiponectin mediated disorder comprising administering a therapeutically effective amount of an adiponectin variant with at least a 3-fold increased solubility relative to residues 110-244 of human adiponectin
    Type: Application
    Filed: May 30, 2006
    Publication date: November 30, 2006
    Inventors: Jonathan Zalevsky, Duc-Hanh Nguyen, Gregory Moore, Sergei Ezhevsky, John Desjarlais, Arthur Chirino, Darian Cash, Matthew Bernett