Abstract: A method of using deep brain stimulation (DBS) for treating mental disorders associated with high connectivity in brain circuits, such as cortico-striato-thalamo-cortical (CSTC) circuits, is provided. The method comprises providing a first electrical signal having a first frequency to a first electrode implanted at a first location within a brain circuit and providing a second electrical signal having a second frequency to a second electrode implanted at a second location within the brain circuit. The first frequency and the second frequency are unequal.

Abstract: Systems and methods for controlling brain activity are provided. In some aspects, a method for controlling a synchrony in brain activity of a subject is provided. The method includes positioning stimulators to stimulate a first region and a second region of a subject's brain, and selecting a pulsed stimulation sequence comprising a first stimulation to the first region and a second stimulation to the second region, wherein the stimulations are timed to be substantially concurrent and separated by a phase lag. The method also includes delivering the pulsed stimulation sequence, using the stimulators, to control a synchrony between the first region and the second region at a predetermined frequency.

Abstract: A method of using deep brain stimulation (DBS) for treating mental disorders associated with high connectivity in brain circuits, such as cortico-striato-thalamo-cortical (CSTC) circuits, is provided. The method comprises providing a first electrical signal having a first frequency to a first electrode implanted at a first location within a brain circuit and providing a second electrical signal having a second frequency to a second electrode implanted at a second location within the brain circuit. The first frequency and the second frequency are unequal.

Abstract: Systems and methods for controlling brain activity are provided. In some aspects, a method for controlling a synchrony in brain activity of a subject is provided. The method includes positioning stimulators to stimulate a first region and a second region of a subject's brain, and selecting a pulsed stimulation sequence comprising a first stimulation to the first region and a second stimulation to the second region, wherein the stimulations are timed to be substantially concurrent and separated by a phase lag. The method also includes delivering the pulsed stimulation sequence, using the stimulators, to control a synchrony between the first region and the second region at a predetermined frequency.

Abstract: The systems and methods described herein include an external base station with a tethered transceiver, an implanted hub that includes power, telemetry, and processing electronics, and a plurality of implanted satellite that contain reconfigurable front-end electronics for interfacing with electrodes. The system can operate in different modes. In a first mode, called a base boost mode, the external base station is used for closed-loop control of stimulation therapies. In a second, autonomous mode, closed-loop control is performed in the hub without direct influence from the base station. In a third mode, streams of neural data are transmitted to an offline processor for offline analysis.