Patents by Inventor Darin E. Jones

Darin E. Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) INHIBITORS AGAINST COVID MACRODOMAIN AND METHODS OF USING THE SAME
    Publication number: 20240109892
    Abstract: The present disclosure provides compounds of Formula (Ia) and Formula (Ib) and the pharmaceutically acceptable salts and solvates thereof, wherein A1, A2, R1, R2, R3, and R4 are defined as set forth in the specification. The present disclosure also provides the use of compounds of Formula (Ia) or Formula (Ib) to treat a coronavirus infection in a subject.
    Type: Application
    Filed: January 24, 2022
    Publication date: April 4, 2024
    Inventors: John A. TAINER, Zamal AHMED, Darin E. JONES, Davide MOIANI, Chris Arlen BROSEY
  • SMALL MOLECULE PARG INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20220202821
    Abstract: The present disclosure provides methods of inhibiting PARG in cancer cells, including methods comprising administering a PARG inhibitor that modulates position Tyr795 in PARG. Also provided herein are methods of treating and/or preventing cancer comprising administering a PARG inhibitor. In some embodiments, the PARG inhibitors are of the formula: wherein the variables are defined herein.
    Type: Application
    Filed: March 27, 2020
    Publication date: June 30, 2022
    Applicants: Board of Regents, The University of Texas System, Board of Trustees of The University of Arkansas, Washington University
    Inventors: John A. TAINER, Zamal AHMED, Darin E. JONES, In-Kwon KIM, Tom ELLENBERGER, Chris HO
  • SMALL MOLECULE GRB2 STABILIZERS FOR RAS MAP KINASE INHIBITION
    Publication number: 20220151991
    Abstract: The present disclosure compounds of the formula (I-A) or (I), wherein the variables are defined herein, as well as pharmaceutical compositions thereof. The present disclosure also provides methods for the use of said compounds and/or pharmaceutical compositions, such as in the treatment of cancer. The present disclosure also provides methods for the use of compounds of the formula (III), wherein the variables are defined herein.
    Type: Application
    Filed: March 13, 2020
    Publication date: May 19, 2022
    Applicants: Board of Regents, The University of Texas System, Board of Trustees of the University of Arkansas
    Inventors: Zamal AHMED, John A. TAINER, Darin E. JONES
  • HETERO-SUBSTITUTED CYCLIC LACTONE ANALOGUES AND USES THEREOF
    Publication number: 20210332062
    Abstract: The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure provides methods of using the SL and SL derivatives to inhibit the growth of leukemic cancer cells.
    Type: Application
    Filed: May 28, 2021
    Publication date: October 28, 2021
    Applicant: Board of Trustees of the University of Arkansas
    Inventors: Monica L. Guzman, Cesar M. Compadre, Paola E. Ordonez, Mariano Martinez, Michael J. Balick, Darin E. Jones, Flavio G. Gaudio
  • Dehydroleucodine derivatives and uses thereof
    Patent number: 11059800
    Abstract: The present invention provides dehydroleucodine derivatives. In particular, the present invention provides amine derivatives of dehydroleucodine and methods of using dehydroleucodine and the amine derivatives of dehydroleucodine to inhibit the growth of cancer cells.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: July 13, 2021
    Assignees: Universidad Tecnica Particular De Loja, Cornell University, BioVentures, LLC
    Inventors: Cesar M. Compadre, Paola E. Ordonez, Monica L. Guzman, Darin E. Jones, Omar Malagon, Giovanni Vidari, Peter Crooks
  • Hetero-substituted cyclic lactone analogues and uses thereof
    Patent number: 11021488
    Abstract: The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure provides methods of using the SL and SL derivatives to inhibit the growth of leukemic cancer cells.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: June 1, 2021
    Assignees: Board of Trustees of the University of Arkansas, BioVentures, LLC, Cornell University, New York Botanical Garden
    Inventors: Monica L. Guzman, Cesar M. Compadre, Paola E. Ordonez, Mariano Martinez, Michael J. Balick, Darin E. Jones, Flavio G. Gaudio
  • HETERO-SUBSTITUTED CYCLIC LACTONE ANALOGUES AND USES THEREOF
    Publication number: 20190345167
    Abstract: The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure provides methods of using the SL and SL derivatives to inhibit the growth of leukemic cancer cells.
    Type: Application
    Filed: July 26, 2019
    Publication date: November 14, 2019
    Applicant: Board of Trustees of the University of Arkansas
    Inventors: Monica L. Guzman, Cesar M. Compadre, Paola E. Ordonez, Mariano Martinez, Michael J. Balick, Darin E. Jones, Flavio G. Gaudio
  • DEHYDROLEUCODINE DERIVATIVES AND USES THEREOF
    Publication number: 20190185442
    Abstract: The present invention provides dehydroleucodine derivatives. In particular, the present invention provides amine derivatives of dehydroleucodine and methods of using dehydroleucodine and the amine derivatives of dehydroleucodine to inhibit the growth of cancer cells.
    Type: Application
    Filed: February 22, 2019
    Publication date: June 20, 2019
    Inventors: Cesar M. Compadre, Paola E. Ordonez, Monica L. Guzman, Darin E. Jones, Omar Malagon, Giovanni Vidari, Peter Crooks
  • HETERO-SUBSTITUTED CYCLIC LACTONE ANALOGUES AND USES THEREOF
    Publication number: 20180319815
    Abstract: The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure provides methods of using the SL and SL derivatives to inhibit the growth of leukemic cancer cells.
    Type: Application
    Filed: November 3, 2016
    Publication date: November 8, 2018
    Applicant: Board of Trustees of the University of Arkansas
    Inventors: Monica L. Guzman, Cesar M. Compadre, Paola E. Ordonez, Mariano Martinez, Michael J. Balick, Darin E. Jones, Flavio G. Gaudio
  • DEHYDROLEUCODINE DERIVATIVES AND USES THEREOF
    Publication number: 20160176839
    Abstract: The present invention provides dehydroleucodine derivatives. In particular, the present invention provides amine derivatives of dehydroleucodine and methods of using dehydroleucodine and the amine derivatives of dehydroleucodine to inhibit the growth of cancer cells.
    Type: Application
    Filed: July 11, 2014
    Publication date: June 23, 2016
    Inventors: Cesar M. Compadre, Paola E. Ordonez, Monica L. Guzman, Darin E. Jones, Omar Malagon, Giovanni Vidari, Peter Crooks
  • Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
    Patent number: 7119094
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: October 10, 2006
    Assignee: Warner-Lambert Company
    Inventors: Michael S. South, John J. Parlow, Darin E. Jones, Brenda Case, Tom Dice, Richard Lindmark, Michael J. Hayes, Melvin L. Rueppel, Rick Fenton, Gary W. Franklin, Horng-Chih Huang, Wei Huang, Carrie Kusturin, Scott A. Long, William L. Neumann, David B. Reitz, John I. Trujillo, Ching-Cheng Wang, Rhonda Wood, Qingping Zeng, Matthew W. Mahoney
  • Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade
    Patent number: 7105559
    Abstract: The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
    Type: Grant
    Filed: October 3, 2002
    Date of Patent: September 12, 2006
    Assignee: Pharmacia Corporation
    Inventors: Michael S. South, Ronald K. Webber, Horng-Chih Huang, Mihaly V. Toth, Alan E. Moormann, Jeffery S. Snyder, Jeffrey A. Scholten, Danny J. Garland, Melvin L. Rueppel, William L. Neumann, Scott Long, Wei Huang, John Trujillo, John J. Parlow, Darin E. Jones, Brenda Case, Michael J. Hayes
  • Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
    Patent number: 7015230
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl uracil compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: March 21, 2006
    Assignee: Pharmacia Corporation
    Inventors: Michael S. South, Darin E. Jones, Melvin L. Rueppel
  • Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
    Patent number: 7015223
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl pyrimidinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: March 21, 2006
    Assignee: Pharmacia Corporation
    Inventors: Michael S. South, Ashton T. Hamme, II, William L. Neumann, Darin E. Jones, Melvin L. Rueppel
  • 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade
    Patent number: 6969715
    Abstract: The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
    Type: Grant
    Filed: October 3, 2002
    Date of Patent: November 29, 2005
    Assignee: Pharmacia Corporation
    Inventors: Michael S. South, Ronald K. Webber, Horng-Chih Huang, Mihaly V. Toth, Alan E. Moormann, Jeffery S. Snyder, Jeffrey A. Scholten, Danny J. Garland, Melvin L. Rueppel, William L. Neumann, Scott Long, Wei Huang, John Trujillo, John J. Parlow, Darin E. Jones, Brenda Case, Michael J. Hayes
  • Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
    Patent number: 6908919
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: June 21, 2005
    Assignee: Pharmacia Corporation
    Inventors: Michael S. South, Brenda L. Case, Thomas A. Dice, Ricky L. Fenton, Gary W. Franklin, Michael J. Hayes, Horng-Chih Huang, Wei Huang, Darin E. Jones, Carrie L. Kusturin, Richard J. Lindmark, Scott A. Long, William L. Neumann, David B. Reitz, John I. Trujillo, Ching-Cheng Wang, Rhonda Wood, Qingping Zeng, Matthew W. Mahoney, John J. Parlow, Melvin L. Rueppel
  • Substituted polycyclic aryl and heteroaryl 1,2,4 - triazinones useful as anticoagulants
    Patent number: 6906068
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl pyrimidinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
    Type: Grant
    Filed: May 17, 2000
    Date of Patent: June 14, 2005
    Assignee: Pharmacia Corporation
    Inventors: Michael S. South, Ashton T. Hamme, II, William L. Neumann, Darin E. Jones
  • Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade
    Patent number: 6828338
    Abstract: The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
    Type: Grant
    Filed: June 19, 2003
    Date of Patent: December 7, 2004
    Assignee: Pharmacia Corporation
    Inventors: Michael J. South, Brenda Case, Danny J. Garland, Michael J. Hayes, Horng-Chih Huang, Wei Huang, Darin E. Jones, William L. Neumann, John J. Parlow, David B. Reitz, Melvin L. Rueppel, Rondald K. Webber
  • Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
    Publication number: 20040116430
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl pyrimidinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
    Type: Application
    Filed: October 7, 2003
    Publication date: June 17, 2004
    Applicant: Pharmacia Corporation
    Inventors: Michael S. South, Ashton T. Hamme, William L. Neumann, Darin E. Jones, Melvin L. Rueppel
  • Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
    Patent number: 6750342
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl pyrimidinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
    Type: Grant
    Filed: May 18, 2000
    Date of Patent: June 15, 2004
    Assignee: Pharmacia Corporation
    Inventors: Michael South, Ashton T. Hamme, II, William L. Neumann, Darin E. Jones, Melvin L. Rueppel