Patents by Inventor Darin Gustin

Darin Gustin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases
    Patent number: 7939538
    Abstract: Compounds are provided having the formula: wherein variables Ra, R1, R2, R3, R4, A1, A4, L, Q, X and subscript n as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
    Type: Grant
    Filed: June 27, 2005
    Date of Patent: May 10, 2011
    Assignee: Amgen Inc.
    Inventors: Zice Fu, Michael G. Johnson, An-Rong Li, Andrew P. Marcus, Julio C. Medina, Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason A. Duquette, Darin Gustin, Jeffrey T. Mihalic, Jiwen Liu
  • Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders
    Patent number: 7799795
    Abstract: Provided herein are compounds of the formula where A1, A2, A3, A4, L, Q, R1, R2, R3, R4, Rx, Ry, Rz, X, Y1, Y2, Y4 and Z are as described herein, and compositions thereof that are useful in the treatment of inflammatory and immune conditions and diseases. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a chemokine receptor.
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: September 21, 2010
    Assignee: Amgen Inc.
    Inventors: Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason A. Duquette, Darin Gustin, Julio C. Medina, Jeffrey T. Mihalic, George R. Tonn
  • Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use
    Patent number: 7375102
    Abstract: Compounds are provided having the formula: wherein variables A1, A2, A3, A4, R1, R2, R3, R4, Q and L are as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
    Type: Grant
    Filed: June 27, 2005
    Date of Patent: May 20, 2008
    Assignee: AMGEN SF, LLC
    Inventors: Zice Fu, Michael G. Johnson, An-Rong Li, Andrew P. Marcus, Julio C. Medina, Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason A. Duquette, Darin Gustin, Jeffrey T. Mihalic, Jiwen Liu
  • Imidazolo-related compounds, compositions and methods for their use
    Patent number: 7271271
    Abstract: Compounds are provided having the formula: wherein variables R0, R1, R2, R3, R4, Q, L and subscript n are as described herein. The subject compounds are useful for treatment of infammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
    Type: Grant
    Filed: June 27, 2005
    Date of Patent: September 18, 2007
    Assignee: Amgen SF, LLC
    Inventors: Zice Fu, Michael G. Johnson, An-Rong Li, Andrew P. Marcus, Julio C. Medina, Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason A. Duquette, Darin Gustin, Jeffrey T. Mihalic
  • Substituted pyrazoles and methods of treatment with substituted pyrazoles
    Publication number: 20070117785
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases or allergic conditions, including atopic allergic conditions, mediated by cathepsin S are described.
    Type: Application
    Filed: October 4, 2006
    Publication date: May 24, 2007
    Inventors: Christopher Butler, Hui Cai, James Edwards, Cheryl Grice, Darin Gustin, Lars Karlsson, Haripada Khatuya, Steven Meduna, Barbara Pio, Joanne Quan, Clark Sehon, Siquan Sun, Kevin Tays, Robin Thurmond, Jianmei Wei, Ann Welton
  • Method for treating allergies using substituted pyrazoles
    Publication number: 20070105841
    Abstract: A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
    Type: Application
    Filed: October 31, 2006
    Publication date: May 10, 2007
    Inventors: J. Breitenbucher, Hui Cai, James Edwards, Cheryl Grice, Yin Gu, Darin Gustin, Lars Karlsson, Haripada Khatuya, Steven Meduna, Barbara Pio, Siquan Sun, Kevin Tays, Robin Thurmond, Jianmei Wei
  • Substituted pyrazoles
    Publication number: 20070021437
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
    Type: Application
    Filed: September 7, 2006
    Publication date: January 25, 2007
    Inventors: Mary Beavers, J. Breitenbucher, Hui Cai, James Edwards, Cheryl Grice, Darin Gustin, Haripada Khatuya, Steven Meduna, Barbara Pio, Kevin Tays, Jianmei Wei
  • Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders
    Publication number: 20070015773
    Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis, type I diabetes, asthma, psoriasis and inflammatory bowel disease.
    Type: Application
    Filed: June 26, 2006
    Publication date: January 18, 2007
    Inventors: Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason Duquette, Darin Gustin, Julio Medina, Jeffrey Mihalic, George Tonn
  • Substituted pyrazoles
    Publication number: 20070010530
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
    Type: Application
    Filed: September 7, 2006
    Publication date: January 11, 2007
    Inventors: Mary Beavers, J. Breitenbucher, Hui Cai, James Edwards, Cheryl Grice, Darin Gustin, Haripada Khatuya, Steven Meduna, Barbara Pio, Kevin Tays, Jianmei Wei
  • Substituted pyrazoles
    Publication number: 20070004747
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
    Type: Application
    Filed: September 7, 2006
    Publication date: January 4, 2007
    Inventors: Mary Beavers, J. Breitenbucher, Hui Cai, James Edwards, Cheryl Grice, Darin Gustin, Haripada Khatuya, Steven Meduna, Barbara Pio, Kevin Tays, Jianmei Wei
  • Substituted pyrazoles
    Publication number: 20070004754
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
    Type: Application
    Filed: September 7, 2006
    Publication date: January 4, 2007
    Inventors: Mary Beavers, J. Breitenbucher, Hui Cai, James Edwards, Cheryl Grice, Darin Gustin, Haripada Khatuya, Steven Meduna, Barbara Pio, Kevin Tays, Jianmei Wei
  • Substituted pyrazoles
    Publication number: 20070004755
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
    Type: Application
    Filed: September 7, 2006
    Publication date: January 4, 2007
    Inventors: Mary Beavers, J. Breitenbucher, Hui Cai, James Edwards, Cheryl Grice, Darin Gustin, Haripada Khatuya, Steven Meduna, Barbara Pio, Kevin Tays, Jianmei Wei
  • Substituted pyrazoles
    Publication number: 20070004738
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
    Type: Application
    Filed: September 7, 2006
    Publication date: January 4, 2007
    Inventors: Mary Beavers, J. Breitenbucher, Hui Cai, James Edwards, Cheryl Grice, Darin Gustin, Haripada Khatuya, Steven Meduna, Barbara Pio, Kevin Tays, Jianmei Wei
  • Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use
    Publication number: 20060069106
    Abstract: Compounds are provided having the formula: wherein variables A1, A2, A3, A4, R1, R2, R3, R4, Q and L are as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
    Type: Application
    Filed: June 27, 2005
    Publication date: March 30, 2006
    Inventors: Zice Fu, Michael Johnson, An-Rong Li, Andrew Marcus, Julio Medina, Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason Duquette, Darin Gustin, Jeffrey Mihalic
  • Imidazolo-related compounds, compositions and methods for their use
    Publication number: 20060069127
    Abstract: Compounds are provided having the formula: wherein variables R0, R1, R2, R3, R4, Q, L and subscript n are as described herein. The subject compounds are useful for treatment of infammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
    Type: Application
    Filed: June 27, 2005
    Publication date: March 30, 2006
    Inventors: Zice Fu, Michael Johnson, An-Rong Li, Andrew Marcus, Julio Medina, Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason Duquette, Darin Gustin, Jeffrey Mihalic
  • Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases
    Publication number: 20060069099
    Abstract: Compounds are provided having the formula: wherein variables Ra, R1, R2, R3, R4, A1, A4, L, Q, X and subscript n as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
    Type: Application
    Filed: June 27, 2005
    Publication date: March 30, 2006
    Inventors: Zice Fu, Michael Johnson, An-Rong Li, Andrew Marcus, Julio Medina, Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason Duquette, Darin Gustin, Jeffrey Mihalic
  • Substituted pyrazoles
    Publication number: 20050245576
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described.
    Type: Application
    Filed: June 30, 2005
    Publication date: November 3, 2005
    Inventors: Christopher Butler, Hui Cai, James Edwards, Cheryl Grice, Darin Gustin, Haripada Khatuya, Steven Meduna, Barbara Pio, Clark Sehon, Kevin Tays, Jianmei Wei
  • Method for treating allergies using substituted pyrazoles
    Publication number: 20050101587
    Abstract: A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
    Type: Application
    Filed: September 5, 2001
    Publication date: May 12, 2005
    Inventors: Christopher Butler, Hui Cai, James Edwards, Cheryl Grice, Yin Gu, Darin Gustin, Lars Karlsson, Haripada Khatuya, Steven Meduna, Barbara Pio, Clark Sehon, Siquan Sun, Kevin Tays, Robin Thurmond, Jianmei Wei