Abstract: A time-of-flight (TOF) mass spectrometer analyzes a sample producing a time series of data points representing amounts of detected ions per unit time. A spectrometer resolution, a spectrometer digitization time period, and a minimum number points per peak needed to maintain the information content of a peak are received. A peak width value is calculated for each point from the resolution and a time of each point. The calculated peak width value for each point is divided by the minimum number points per peak. A maximum time difference between points for each point is produced. A point is selected based on the digitization time period. Adjacent points of the selected point are found. If a difference between the adjacent points does not exceed a sum of a maximum time differences of the adjacent points, the selected point is deleted to compress the time series.

Abstract: A time-of-flight (TOF) mass spectrometer analyzes a sample producing a time series of data points representing amounts of detected ions per unit time. A spectrometer resolution, a spectrometer digitization time period, and a minimum number points per peak needed to maintain the information content of a peak are received. A peak width value is calculated for each point from the resolution and a time of each point. The calculated peak width value for each point is divided by the minimum number points per peak. A maximum time difference between points for each point is produced. A point is selected based on the digitization time period. Adjacent points of the selected point are found. If a difference between the adjacent points does not exceed a sum of a maximum time differences of the adjacent points, the selected point is deleted to compress the time series.

Abstract: A mass analyzer system includes an ion inlet that receives a flow of ions, a multi-mode ion controller that controls some or all of the ions, and a multi-mode mass analyzer, in communication with the ion controller, that performs at least one of analyzing and controlling some or all of the ions. The system also includes a detector, in communication with the multi-mode mass analyzer, that detects some or all of the ions and a processor that controls the operation of at least one of the multi-mode ion controller and the multimode mass analyzer.

Abstract: Disclosed are compositions and methods for sensitive detection of one or multiple analytes. In general, the methods involve the use of special label components, referred to as multidimension signals. In the disclosed methods, analysis of multidimension signals can result in one or more predetermined patterns that serve to indicate whether a further level of analysis can or should be performed and/or which portion(s) of the analyzed material can or should be analyzed in a further level of analysis. In some forms, isobaric and non-isobaric elements can be used together in the same assay or assay system. Isobaric and non-isobaric multidimension signals used together can generate one or more predetermined patterns during analysis. The pattern generated in this first level of analysis indicates whether the second level of analysis should be performed. The second level of analysis can involve distinguishing the isobaric multidimension signals.

Abstract: Disclosed are compositions and methods for sensitive detection of one or multiple analytes. In general, the methods involve the use of special label components, referred to as reporter signals, that can be associated with, incorporated into, or otherwise linked to the analytes. In some embodiments, the reporter signals can be altered such that the altered forms of different reporter signals can be distinguished from each other. In some embodiments, sets of reporter signals can be used where two or more of the reporter signals in a set have one or more common properties that allow the reporter signals having the common property to be distinguished and/or separated from other molecules lacking the common property.

Abstract: Compositions for testing, evaluating and calibrating detection instruments and methods for making such compositions are described. The compositions comprise a testing feature or plurality of testing features wherein the testing feature or plurality of testing features comprise a detectable substance and are used to evaluate the performance of a detection device. The compositions are useful for analyzing detection limits, sensitivity, image resolution, dynamic range and other parameters. They can also be used to compare data generated by different instruments, in different labels, in different labs or with different optics.