Patents by Inventor Darin Michael Abbadessa

Darin Michael Abbadessa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VARIANT ONCOLYTIC VACCINIA VIRUS AND METHODS OF USE THEREOF
    Publication number: 20230002740
    Abstract: The present disclosure provides a replication-competent, recombinant oncolytic vaccinia virus (OVV) comprising one of more of a) a nucleotide sequence encoding a variant A33 polypeptide, b) a nucleotide sequence encoding a variant A34 polypeptide, and c) a nucleotide sequence encoding a variant B5 polypeptide, wherein the variant A33, variant A34, and variant B5 polypeptides comprise one or more amino acid substitutions that provide for enhanced virus spreading or enhanced EEV production as compared with a virus encoding a corresponding wild-type A33, A 34, and B5 polypeptide. The present disclosure also provides compositions comprising the OVV and use of the OVV or the composition for inducing oncolysis in an individual having a tumor.
    Type: Application
    Filed: December 9, 2020
    Publication date: January 5, 2023
    Inventors: David H. Kirn, Liliana Maruri Avidal, Todd Brandon Slaby, Darin Michael Abbadessa, Nathaniel Phillip Gulizia, Melissa A. Kotterman