Abstract: Compositions and methods are described for the delivery of a fully human post-translaionally modified (HuPTM) monoclonal antibody (“mAh”) or the antigen-binding fragment of a mAh against human vascular endothelial growth factor (“hVEGF”)—such as, e.g., a fully human-glycosylated (HuGly) anti-hVEGF antigen-binding fragment—to the retina/vitreal humour in the eye(s) of human subjects diagnosed with diabetic retinopathy.

Abstract: Compositions and methods are described for the delivery of therapeutic products (such as therapeutic proteins (for example, antibodies), therapeutic RNAs (for example, shRNAs, siRNAs, and miRNAs), and therapeutic aptamers) to the retina/vitreal humour in the eyes of human subjects to treat pathologies of the eye, involving, for example, recombinant viral vectors such as recombinant adeno-associated virus (rAAV) vectors.

Abstract: A spring is provided that exhibits a variable and non-linear loading response upon compression. The spring comprises a continuous wire having a lower end convolution, an upper end convolution, and a plurality of helical intermediate convolutions. The upper end convolution, the lower end convolution, and the helical intermediate convolutions each have a respective diameter, with the continuous wire further defining a pitch between the various convolutions. In the spring, one or more of the diameters of the convolutions or one or more of the pitches varies along the length of the continuous wire such that the spring exhibits a non-linear loading response upon compression. A mattress is further provided and includes a plurality of the springs arranged in a matrix.

Abstract: A spring is provided that exhibits a variable and non-linear loading response upon compression. The spring comprises a continuous wire having a lower end convolution, an upper end convolution, and a plurality of helical intermediate convolutions. The upper end convolution, the lower end convolution, and the helical intermediate convolutions each have a respective diameter, with the continuous wire further defining a pitch between the various convolutions. In the spring, one or more of the diameters of the convolutions or one or more of the pitches varies along the length of the continuous wire such that the spring exhibits a non-linear loading response upon compression. A mattress is further provided and includes a plurality of the springs arranged in a matrix.

Abstract: A spring is provided that exhibits a variable and non-linear loading response upon compression. The spring comprises a continuous wire having a lower end convolution, an upper end convolution, and a plurality of helical intermediate convolutions. The upper end convolution, the lower end convolution, and the helical intermediate convolutions each have a respective diameter, with the continuous wire further defining a pitch between the various convolutions. In the spring, one or more of the diameters of the convolutions or one or more of the pitches varies along the length of the continuous wire such that the spring exhibits a non-linear loading response upon compression. A mattress is further provided and includes a plurality of the springs arranged in a matrix.

Abstract: A spring is provided that exhibits a variable and non-linear loading response upon compression. The spring comprises a continuous wire having a lower end convolution, an upper end convolution, and a plurality of helical intermediate convolutions. The upper end convolution, the lower end convolution, and the helical intermediate convolutions each have a respective diameter, with the continuous wire further defining a pitch between the various convolutions. In the spring, one or more of the diameters of the convolutions or one or more of the pitches varies along the length of the continuous wire such that the spring exhibits a non-linear loading response upon compression. A mattress is further provided and includes a plurality of the springs arranged in a matrix.

Abstract: A blanket for use by one or more persons, the blanket comprising a sheet of material having a top edge, a bottom edge, and a pair of side edges, the top edge is reinforced and substantially linear, the top edge has a first end, a middle and a second end, a first opening located between the middle of the top edge and the first end of the blanket, the opening being designed to fit closely to a neck of a first person using the blanket and a second opening located between the middle of the top edge and the second end of the blanket, the opening being designed to fit closely to a neck of a second person using the blanket, wherein each opening permits a blanket to be securely tucked in behind the neck, shoulders and head of the first person and the second person using the blanket.

Abstract: A marketing method for a business is disclosed. The method comprises the steps of selecting at least one other business which may involve analysis of certain characteristics of the workforce of that business. The method further involves negotiating an agreement with the other business to locate within the premises of that other business a support member The support member includes printed indicia relating to goods and/or services of the first business. The support member also has a receptacle for business cards of a representative of the first method. The method further involves locating the support member in the premises of the other business and replacing promotional brochure and/or replenishing business at spaced time intervals. The support member may be located in a staff room, lunch room, waiting room or a restroom. The method preferably involves numerous re-visits to the other business and presentations to the staff and/or clients of the other business.

Abstract: Disposable electric cooking grill liners for protecting an electric cooking grill having a heated grilling surface of each of the pivotally connected moveable and stationary grilling members. Each grilling surface is heated and has raised cooking ribs wherein both sides of food placed between the closed grilling surfaces are simultaneously heated. Each grill liner is formed of a sheet of semi-rigid or heavy heat conductive foil preformed for fitting directly against and substantially conforming to and covering the corresponding grilling surface whereby cooking heat provided to each grilling surface is substantially transferred through the grilling liner without substantial food and juices flowing therefrom coming in contact with the grilling surfaces. Each grill liner also has a rigidized or stiffened margin for maintaining the preformed shape during installation, use and removal of each said grill liner after use.

Abstract: Disposable electric cooking grill liners for protecting an electric cooking grill having a heated grilling surface of each of the pivotally connected moveable and stationary grilling members. Each grilling surface is heated and has raised cooking ribs wherein both sides of food placed between the closed grilling surfaces are simultaneously heated. Each grill liner is formed of an unperforated sheet of semi-rigid or heavy aluminum foil preformed for fitting directly against and substantially conforming to and covering the corresponding grilling surface whereby cooking heat provided to each grilling surface is substantially transferred through the grilling liner without food and juices flowing therefrom coming in contact with the grilling surfaces. Each grill liner also has a rigidized outturned margin formed of multiple layers of foil folded over on itself for maintaining the preformed shape during installation, use and removal of each said grill liner after use.