Abstract: A microfluidic device comprises a first substrate (102) made of a first polymer material and a second substrate (104) made of a second polymer material, the first (102) and second (104) substrates having respective bonding surfaces (23, 41), at least one of the bonding surfaces (41) having channel formations (14) so that, when the bonding surfaces (23, 41) are bonded by surface deformation to one another, the bonded first and second substrates (102, 104) and the channel formations (14) form at least part of a microfluidic channel network comprising a plurality of microfluidic channels, wherein one or more indicator pits (11), separate to the channel formations (14) defining the microfluidic channel network, are formed in at least one of the bonding surfaces (23, 41), so that surface deformation caused by the bonding process causes a change of configuration of the one or more indicator pits (11).

Abstract: A microfluidic device includes a first substrate made of a first polymer material and a second substrate made of a second polymer material, the first and second substrates having respective bonding surfaces, at least one of the bonding surfaces having channel formations so that, when the bonding surfaces are bonded by surface deformation to one another, the bonded first and second substrates and the channel formations form at least part of a microfluidic channel network comprising a plurality of microfluidic channels, wherein one or more indicator pits, separate to the channel formations defining the microfluidic channel network, are formed in at least one of the bonding surfaces, so that surface deformation caused by the bonding process causes a change of configuration of the one or more indicator pits.

Abstract: A microfluidic device includes first and second outer layers each having one or more microfluidic formations and an intermediate layer bonded between the first and second outer layers; in which the glass transition temperature of the first outer layer is higher than the glass transition temperature of the second outer layer.

Abstract: A microfluidic device comprises a first substrate (102) made of a first polymer material and a second substrate (104) made of a second polymer material, the first (102) and second (104) substrates having respective bonding surfaces (23, 41), at least one of the bonding surfaces (41) having channel formations (14) so that, when the bonding surfaces (23, 41) are bonded by surface deformation to one another, the bonded first and second substrates (102, 104) and the channel formations (14) form at least part of a microfluidic channel network comprising a plurality of microfluidic channels, wherein one or more indicator pits (11), separate to the channel formations (14) defining the microfluidic channel network, are formed in at least one of the bonding surfaces (23, 41), so that surface deformation caused by the bonding process causes a change of configuration of the one or more indicator pits (11).

Abstract: A microfluidic device comprises a first substrate made of a first polymer material and a second substrate made of a second material, the first and second substrates having respective bonding surfaces, at least one of the bonding surfaces having fluid-carrying formations so that, when the bonding surfaces are bonded by surface deformation to one another, the bonded first and second substrates and the fluid-carrying formations form at least part of a microfluidic channel network comprising a plurality of microfluidic channels, in which one or more bonding formations, separate to the fluid-carrying formations defining the microfluidic channel network, are formed so as to roughen at least one of the bonding surfaces.

Abstract: A microfluidic device includes a first substrate made of a first polymer material and a second substrate made of a second polymer material, the first and second substrates having respective bonding surfaces, at least one of the bonding surfaces having channel formations so that, when the bonding surfaces are bonded by surface deformation to one another, the bonded first and second substrates and the channel formations form at least part of a microfluidic channel network comprising a plurality of microfluidic channels, wherein one or more indicator pits, separate to the channel formations defining the microfluidic channel network, are formed in at least one of the bonding surfaces, so that surface deformation caused by the bonding process causes a change of configuration of the one or more indicator pits.

Abstract: A microfluidic device comprising in sequence first, second and third layers of plastics materials. A microfluidic circuit including a laterally extending microfluidic channel is formed at the interface between the first and second layers by surface structure in one or both of the first and second layers. A via is formed in the third layer for supplying or removing fluid to or from the microfluidic circuit. A conduit is formed in the second layer to provide fluid communication between the microfluidic channel and the via. A weld is formed at the interface between the second and third layers in a continuous closed path around the via and forms a fluid-tight seal for fluid flow between the via and the microfluidic circuit.

Abstract: A microfluidic device comprising in sequence first, second and third layers of plastics materials. A microfluidic circuit including a laterally extending microfluidic channel is formed at the interface between the first and second layers by surface structure in one or both of the first and second layers. A via is formed in the third layer for supplying or removing fluid to or from the microfluidic circuit. A conduit is formed in the second layer to provide fluid communication between the microfluidic channel and the via. A weld is formed at the interface between the second and third layers in a continuous closed path around the via and forms a fluid-tight seal for fluid flow between the via and the microfluidic circuit.

Abstract: The present invention relates to microfluidic devices that include a reliable seal between a substrate of the device and a fluid transport mechanism. The devices of the invention include at least one internal channel, and at least one port in fluid communication with the channel. A seal is associated with the port and is configured to receive a fluid transport mechanism. The seal is formed from an elastomeric material that is compatible for use with fluorinated oil and resists flaking and degradation.