Abstract: Described herein are mucoadhesive pharmaceutical compositions of corticosteroids, as well as methods of making such pharmaceutical compositions, and therapeutic methods using them. The compositions typically comprise a corticosteroid in a mucoadhesive system, wherein the mucoadhesive system comprises a rheology-modifying agent and a vehicle for the corticosteroid. The compositions are particularly useful for treating inflammatory conditions of the esophagus, such as eosinophilic esophagitis, or inflammatory bowel disease.

Abstract: The application relates to an applicator system (1) for applying a viscous liquid, in particular a transdermal pharmaceutical formulation, to the human skin comprising a metering dispenser (2) in turn comprising a container holding the viscous liquid and a pump (5) for metering the liquid and an applicator (3) detachably connected to the dispenser (2) and comprising an application surface (6) for receiving a metered amount of the liquid from the dispenser (2). The application surface (6) is convex.

Abstract: The application relates to an applicator system (1) for applying a viscous liquid, in particular a transdermal pharmaceutical formulation, to the human skin comprising a metering dispenser (2) in turn comprising a container holding the viscous liquid and a pump (5) for metering the liquid and an applicator (3) detachably connected to the dispenser (2) and comprising an application surface (6) for receiving a metered amount of the liquid from the dispenser (2). The application surface (6) is convex.

Abstract: A pharmaceutical composition for transdermal or transmucosal delivery of a pharmaceutical agent effective to treat a neurological disorder such as Parkinson's disease is disclosed. The composition contains an antioxidant, which provides color and chemical stability of the pharmaceutical agent. The antioxidant may also provide enhanced skin permeability of the agent.

Abstract: A pharmaceutical composition in the form of a solution, cream, lotion, spray, ointment, gel, aerosol, tablet, suppository or patch device for transdermal or transmucosal administration of alprazolam to a subject, which includes as a permeation enhancing mixture a fatty component in an amount of 0.1% to 20% by weight which is one of (a) a saturated fatty alcohol of formula CH3—(CH2)n—CH2OH, a saturated fatty acid of formula CH3—(CH2)n—CH2COOH, (b) an unsaturated fatty alcohol of formula CH3(CnH2(n?1))—OH, or (c) a fatty acid of formula CH3(CnH2(n?1))—COOH, wherein n is an integer of between 8 and 22; and a vehicle that includes a C1-C4 alkanol, a polyalcohol, and water.

Abstract: The present invention relates generally to formulations for transdermal or transmucosal administration of an active agent such as estradiol. The invention is a substantially malodorous-free and irritation free transdermal formulation which is substantially free of long chain fatty alcohols, long-chain fatty acids, and long-chain fatty esters.

Abstract: The present invention refers to a pharmaceutical composition suitable for the transdermal or transmucosal administration of one or more active agents, in form of a gel or a solution, comprising as a permeation enhancers a combination of: a) saturated fatty alcohol of formula CH3—(CH2)n—CH2OH or saturated fatty acid CH3—(CH2)n—CH2COOH wherein n is an integer number 8÷22, preferably 8÷12, most preferably 10, or unsaturated fatty alcohol or fatty acid of formula: CH3(CnH2(n-1))—OH or CH3(CnH2(n-1))—COOH wherein n is an integer number 8÷22, b) a ternary vehicle or carrier consisting of a C1÷C4 alkanol, a polyalcohol in particular propylenglycol and water, c) optionally also a monoalkylether of diethylenglycol.

Abstract: A pharmaceutical composition in the form of a solution, cream, lotion, spray, ointment, gel, aerosol, tablet, suppository or patch device for transdermal or transmucosal administration of alprazolam to a subject, which includes as a permeation enhancing mixture a fatty component in an amount of 0.1% to 20% by weight which is one of (a) a saturated fatty alcohol of formula CH3—(CH2)n—CH2OH, a saturated fatty acid of formula CH3—(CH2)n—CH2COOH, (b) an unsaturated fatty alcohol of formula CH3(CnH2(n?1))—OH, or (c) a fatty acid of formula CH3(CnH2(n?l))—COOH, wherein n is an integer of between 8 and 22; and a vehicle that includes a C1-C4 alkanol, a polyalcohol, and water.

Abstract: The present invention refers to a pharmaceutical composition suitable for the transdermal or transmucosal administration of one or more active agents, in form of a gel or a solution, comprising as a permeation enhancers a combination of: a) saturated fatty alcohol of formula CH3—(CH2)n—CH2OH or saturated fatty acid CH3—(CH2)n—CH2COOH wherein n is an integer number 8÷22, preferably 8÷12, most preferably 10, or unsaturated fatty alcohol or fatty acid of formula: CH3(CnH2(n−1))—OH or CH3(CnH2(n−1))—COOH wherein n is an integer number 8÷22, b) a ternary vehicle or carrier consisting of a C1÷C4 alkanol, a polyalcohol in particular propylenglycol and water, c) optionally also a monoalkylether of diethylenglycol.

Abstract: A patch for transdermal administration of drugs through controlled release system, consisting essentially of: A) a flexible backing layer; B) an adhesive layer comprising: an adhesive pressure sensitive adhesive polymeric matrix, a cohesion improver, a tackifier agent, a combination of permeation enhancers consisting of a first component which is a saturated fatty acid or fatty alcohol represented by the formula CH3—(CH2)n—COOH or CH3—(CH2)n—CH2OH respectively, in which n is an integer from 6 to 16, and of a second component which is a monounsaturated fatty acid or fatty alcohol represented by the formula CH3—(CnH2(n−1))—COOH or CH3—(CnH2(n−1))—CH2OH respectively, in which n is an integer from 8 to 22, with the provision that the chain lenght of the first component is different from that of the second component, C) a protective liner, which is removed at the moment of use.

Abstract: Pharmaceutical formulation in the form of a gel suitable for the transdermal administration of an active agent of the class of estrogens or of progestin class or of a mixture of both, comprising:as permeation enhancers of the above said active agents a combination consisting substantially of an aliphatic alcohol having general formula CH3(CH2)nCH20H wherein n=8-16 and of a monoalkylether of diethylene glycol;as a vehicle or carrier, a combination of an alkanol of 2.div.4 C atoms, a glycol and water;as gelling agent a polymer or copolymer of acrylic acid;a tertiary amine as a thickening and neutralizing agent.