Patents by Inventor Dario Slavazza
Dario Slavazza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11845056Abstract: A peptide synthesis instrument can be used for small scale peptide synthesis. The instrument can include several unique features, including a compression style reaction vessel permitting quick setup of the reaction vessel, a double reaction vessel system permitting efficient mixing without loss of solvent or solvent-to-resin contact, gravity-fed heated reservoirs establishing a fixed volume for delivery to the reaction vessel, fume-free solvent addition permitting solvent addition to fixed bottles, and an improved amino acid manifold assembly which reduces the number of components and increases the ease of use of the instrument. Each of these features improve upon the current state of the art in solid phase automated peptide synthesizers.Type: GrantFiled: November 15, 2022Date of Patent: December 19, 2023Assignee: CSBIO INSTRUMENTATION CO.Inventors: Dario Slavazza, Yoheng Chang, David Lippoth
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Patent number: 11806688Abstract: A peptide synthesis instrument can be used for small scale peptide synthesis. The instrument can include several unique features, including a compression style reaction vessel permitting quick setup of the reaction vessel, a double reaction vessel system permitting efficient mixing without loss of solvent or solvent-to-resin contact, gravity-fed heated reservoirs establishing a fixed volume for delivery to the reaction vessel, fume-free solvent addition permitting solvent addition to fixed bottles, and an improved amino acid manifold assembly which reduces the number of components and increases the ease of use of the instrument. Each of these features improve upon the current state of the art in solid phase automated peptide synthesizers.Type: GrantFiled: September 27, 2021Date of Patent: November 7, 2023Assignee: CSBIO INSTRUMENTATION CO.Inventors: Dario Slavazza, Yoheng Chang, David Lippoth
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Publication number: 20230071904Abstract: A peptide synthesis instrument can be used for small scale peptide synthesis. The instrument can include several unique features, including a compression style reaction vessel permitting quick setup of the reaction vessel, a double reaction vessel system permitting efficient mixing without loss of solvent or solvent-to-resin contact, gravity-fed heated reservoirs establishing a fixed volume for delivery to the reaction vessel, fume-free solvent addition permitting solvent addition to fixed bottles, and an improved amino acid manifold assembly which reduces the number of components and increases the ease of use of the instrument. Each of these features improve upon the current state of the art in solid phase automated peptide synthesizers.Type: ApplicationFiled: November 15, 2022Publication date: March 9, 2023Inventors: Dario SLAVAZZA, Yoheng CHANG, David LIPPOTH
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Publication number: 20230071378Abstract: A process for making an oligonucleotide, the process including reacting a oligonucleotide precursor with a solid phase support within a reaction vessel, the reaction vessel being coupled to an actuator and having a resting position and inverting the reaction vessel via the actuator such that the reaction vessel is inverted relative to the resting position, wherein the inversion of the reaction vessel results in stirring of the solid phase support within the reaction vessel.Type: ApplicationFiled: November 15, 2022Publication date: March 9, 2023Inventors: Dario Slavazza, Heng Wei Chang, Yoheng Hanson Chang
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Patent number: 11571677Abstract: A peptide synthesis instrument can be used for small scale peptide synthesis. The instrument can include several unique features, including a compression style reaction vessel permitting quick setup of the reaction vessel, a double reaction vessel system permitting efficient mixing without loss of solvent or solvent-to-resin contact, gravity-fed heated reservoirs establishing a fixed volume for delivery to the reaction vessel, fume-free solvent addition permitting solvent addition to fixed bottles, and an improved amino acid manifold assembly which reduces the number of components and increases the ease of use of the instrument. Each of these features improve upon the current state of the art in solid phase automated peptide synthesizers.Type: GrantFiled: October 28, 2020Date of Patent: February 7, 2023Assignee: CSBIO INSTRUMENTATION CO.Inventors: Dario Slavazza, Yoheng Chang, David Lippoth
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Patent number: 11524976Abstract: A process for making an oligonucleotide, the process including reacting a oligonucleotide precursor with a solid phase support within a reaction vessel, the reaction vessel being coupled to an actuator and having a resting position and inverting the reaction vessel via the actuator such that the reaction vessel is inverted relative to the resting position, wherein the inversion of the reaction vessel results in stirring of the solid phase support within the reaction vessel.Type: GrantFiled: August 28, 2020Date of Patent: December 13, 2022Assignee: C S Bio Co.Inventors: Dario Slavazza, Heng Wei Chang, Yoheng Hanson Chang
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Publication number: 20220126259Abstract: A peptide synthesis instrument can be used for small scale peptide synthesis. The instrument can include several unique features, including a compression style reaction vessel permitting quick setup of the reaction vessel, a double reaction vessel system permitting efficient mixing without loss of solvent or solvent-to-resin contact, gravity-fed heated reservoirs establishing a fixed volume for delivery to the reaction vessel, fume-free solvent addition permitting solvent addition to fixed bottles, and an improved amino acid manifold assembly which reduces the number of components and increases the ease of use of the instrument. Each of these features improve upon the current state of the art in solid phase automated peptide synthesizers.Type: ApplicationFiled: October 28, 2020Publication date: April 28, 2022Inventors: Dario SLAVAZZA, Yoheng CHANG, David LIPPOTH
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Publication number: 20220126260Abstract: A peptide synthesis instrument can be used for small scale peptide synthesis. The instrument can include several unique features, including a compression style reaction vessel permitting quick setup of the reaction vessel, a double reaction vessel system permitting efficient mixing without loss of solvent or solvent-to-resin contact, gravity-fed heated reservoirs establishing a fixed volume for delivery to the reaction vessel, fume-free solvent addition permitting solvent addition to fixed bottles, and an improved amino acid manifold assembly which reduces the number of components and increases the ease of use of the instrument. Each of these features improve upon the current state of the art in solid phase automated peptide synthesizers.Type: ApplicationFiled: September 27, 2021Publication date: April 28, 2022Inventors: Dario SLAVAZZA, Yoheng CHANG, David LIPPOTH
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Publication number: 20210061844Abstract: The disclosure provides a new and improved oligonucleotide synthesizer.Type: ApplicationFiled: August 28, 2020Publication date: March 4, 2021Inventors: Dario Slavazza, Heng Wei Chang, Yoheng Hanson Chang
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Publication number: 20170313740Abstract: The present invention provides methods of preparing a peptide having an N-terminal histidine, and compositions comprising a plurality of peptides prepared by the methods. The methods disclosed herein reduce racemization of the N-terminal histidine in the peptides during the synthesis process, thereby improving the yield and purity of the peptide compositions. Exemplary peptides that can be manufactured with the methods include Exenatide, Lixisenatide, and Liraglutide.Type: ApplicationFiled: April 27, 2017Publication date: November 2, 2017Inventors: Wei WANG, Jason CHANG, Dario SLAVAZZA, Heng Wei CHANG
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Patent number: 6320025Abstract: Reaction vessels suitable for solid phase polymer synthesis generally comprise: a housing defining a chamber for containing a resin, said housing having an operable inlet port and an operable outlet port in fluid communication with said chamber; and an elongate resin filter having an interior bore, and adapted to enable filtered fluid flow from an exterior inlet surface thereof into the filter interior bore, said filter being disposed in said chamber and having an outlet connection fluidly coupling said filter interior bore to the housing outlet port such that fluid flowing through the housing inlet port into the chamber passes through the filter inlet surface, into the filter interior bore and out the housing outlet port.Type: GrantFiled: July 29, 1999Date of Patent: November 20, 2001Inventors: Dario Slavazza, Heng Wei Chang