Patents by Inventor Darja Obrstar

Darja Obrstar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selection of triploid CHO cells and cell lines expressing recombinant polypeptides as high producers
    Patent number: 9499857
    Abstract: The present invention relates to a method for selecting for cells or cell lines that produce a recombinant protein/polypeptide in high yields, the method allowing for the selection of high producer cells or cell lines in an early phase of cell line development, the method comprising the step of determining the nuclear DNA content of the cells or cell lines, wherein the level of the nuclear DNA content of the cells or cell lines positively correlates with the capacity of the cells or cell lines to produce the recombinant protein/polypeptide.
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: November 22, 2016
    Assignee: LEK PHARMACEUTICALS D.D.
    Inventor: Darja Obrstar
  • NUCLEAR DNA CONTENT OF CHO CELL LINES AS A SELECTION CRITERION IN SCREENING OF THE BEST RECOMBINANT PROTEIN PRODUCERS
    Publication number: 20130302816
    Abstract: The present invention relates to a method for selecting for cells or cell lines that produce a recombinant protein/polypeptide in high yields, the method allowing for the selection of high producer cells or cell lines in an early phase of cell line development, the method comprising the step of determining the nuclear DNA content of the cells or cell lines, wherein the level of the nuclear DNA content of the cells or cell lines positively correlates with the capacity of the cells or cell lines to produce the recombinant protein/polypeptide.
    Type: Application
    Filed: November 9, 2011
    Publication date: November 14, 2013
    Applicant: LEK PHARMACEUTICALS D.D.
    Inventor: Darja Obrstar