Patents by Inventor Darko Kontrec

Darko Kontrec has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chiral stationary phases for chromatography based on aromatic allyl amines
    Patent number: 8202417
    Abstract: New chiral stationary phases (CSPs) based on chiral selectors covalently bound on a solid support were prepared. Chiral selectors were obtained from enantiomerically pure aromatic amines and 3,5-dinitrobenzoic acid and then linked to the support surface through the allylic double bond. Such obtained materials allow enantioseparation of racemates or enantiomerically enriched compounds. These chiral stationary phases can be used as fillings in chromatographic columns for enantiomer separation of naproxen type drugs and other similar non-steroidal anti-inflammatory drugs (NSAID) by means of high performance liquid chromatography on both the analytical and preparative scale.
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: June 19, 2012
    Assignee: Rudjer Boskovic Institute
    Inventors: Vladimir Vinkovic, Darko Kontrec, Goran Landek
  • Chiral Stationary Phases For Chromatography Based On Aromatic Allyl Amines
    Publication number: 20110094966
    Abstract: New chiral stationary phases (CSPs) based on chiral selectors covalently bound on a solid support were prepared. Chiral selectors were obtained from enantiomerically pure aromatic amines and 3,5-dinitrobenzoic acid and then linked to the support surface through the allylic double bond. Such obtained materials allow enantioseparation of racemates or enantiomerically enriched compounds. These chiral stationary phases can be used as fillings in chromatographic columns for enantiomer separation of naproxen type drugs and other similar non-steroidal anti-inflammatory drugs (NSAID) by means of high performance liquid chromatography on both the analytical and preparative scale.
    Type: Application
    Filed: December 6, 2010
    Publication date: April 28, 2011
    Inventors: Vladimir Vinkovic, Darko Kontrec, Goran Landek
  • Chiral stationary phases based on derivatives of 4-amino-3,5-dinitrobenzoic acid
    Patent number: 7018537
    Abstract: The invention describes new chiral stationary phases containing a 4-amino-3,5-dinitrobenzoic unit modified with chiral groups and spacer groups. The invention includes the process for the preparation of said stationary phases starting from 4-halogenated derivative of 3,5-dinitrobenzoic acid, chiral selectors obtainable as intermediates in the aforesaid process, and the use of the chiral stationary phases in the separation of enantiomers.
    Type: Grant
    Filed: March 6, 2002
    Date of Patent: March 28, 2006
    Assignee: Chirallica d.o.o.
    Inventors: Darko Kontrec, Vladimir Vinkovic, Vitomir Sunjic, Paolo Mariotti, Luciano Navarini
  • Chiral stationary phases based on derivatives of 4-amino-3,5-dinitrobenzoic acid
    Publication number: 20040144708
    Abstract: The invention describes new chiral stationary phases containing a 4-amino-3,5-dinitrobenzoic unit modified with chiral groups and spacer groups. The invention includes the process for the perparation of said stationary phases starting from 4-halogenated derivative of 3,5-dinitrobenzoic acid, chiral selectors obtainable as intermediates in the aforesaid process, and the use of the chiral stationary phases in the separation of enantiomers.
    Type: Application
    Filed: February 24, 2004
    Publication date: July 29, 2004
    Inventors: Darko Kontrec, Vladimir Vinkovic, Vitomir Sunjic, Paolo Mariotti, Luciano Navarini
  • Chiral stationary phases for enantiomers separation and their preparation
    Patent number: 6437167
    Abstract: The present invention describes new chiral stationary phases and optically active compounds therein contained. The optically active compounds contained in the stationary phases are represented by the formula of structure (I), containing at least one asymmetric carbon atom, and a substituent acting as a spacer. The stationary phases of the present invention are useful in the preparation of chromatographic columns useful for the separation of enantiomers.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: August 20, 2002
    Assignee: Societa' Cooperative Centro Ricerche Polytech A Responsabilitia' Limitata
    Inventors: Vitomir Sunjic, Darko Kontrec, Vladimir Vinkovic