Patents by Inventor Darl Flake

Darl Flake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENES AND GENE SIGNATURES FOR DIAGNOSIS AND TREATMENT OF MELANOMA
    Publication number: 20240200145
    Abstract: Panels of biomarkers, methods and systems are disclosed for determining gene expression, and diagnosing and treating melanoma.
    Type: Application
    Filed: October 25, 2023
    Publication date: June 20, 2024
    Inventors: Michael Bryan WARF, Benjamin ROA, Alexander GUTIN, Darl FLAKE
  • METHODS FOR CARDIOVASCULAR DISEASE IN RHEUMATOID ARTHRITIS
    Publication number: 20240077499
    Abstract: This invention includes methods for assessing and treating risk of cardiovascular disease (CVD) in a subject with an inflammatory disease, for example rheumatoid arthritis (RA). Provided are methods for assessing risk, for recommending therapy, for prognosis and monitoring, and for treatment, which are advantageously accurate for CVD in RA. The methods include measuring quantitative data for biomarkers, calculating a CVD risk score for a subject using training data, and validating the CVD risk score with a set of validation clinical data.
    Type: Application
    Filed: September 10, 2021
    Publication date: March 7, 2024
    Inventors: JEFFREY R. CURTIS, ALEXANDER GUTIN, JERRY LANCHBURY, ERIC SASSO, DARL FLAKE, ELENA HITRAYA, CHERYL CHIN
  • Genes and gene signatures for diagnosis and treatement of melanoma
    Patent number: 11834719
    Abstract: Panels of biomarkers, methods and systems are disclosed for determining gene expression, and diagnosing and treating melanoma.
    Type: Grant
    Filed: May 20, 2021
    Date of Patent: December 5, 2023
    Assignee: MYRIAD MYPATH, LLC
    Inventors: Michael Bryan Warf, Benjamin Roa, Alexander Gutin, Darl Flake
  • GENES AND GENE SIGNATURES FOR DIAGNOSIS AND TREATMENT OF MELANOMA
    Publication number: 20230340615
    Abstract: Panels of biomarkers, methods and systems are disclosed for determining gene expression, and diagnosing and treating melanoma.
    Type: Application
    Filed: February 3, 2023
    Publication date: October 26, 2023
    Applicant: MYRIAD MYPATH, LLC
    Inventors: Michael Bryan WARF, Benjamin ROA, Alexander GUTIN, Darl FLAKE
  • METHODS OF PREDICTING DISEASE PROGRESSION IN RHEUMATOID ARTHRITIS
    Publication number: 20230142317
    Abstract: Methods for evaluating the risk of radiographic progression in a subject with RA are provided. Also provided are methods of determining treatment efficacy for a subject with RA. Methods of selecting a treatment regimen for a subject with RA are also provided.
    Type: Application
    Filed: April 8, 2021
    Publication date: May 11, 2023
    Inventors: Darl Flake, Eric Sasso
  • Genes and gene signatures for diagnosis and treatment of melanoma
    Patent number: 11584967
    Abstract: Panels of biomarkers, methods and systems are disclosed for determining gene expression, and diagnosing and treating melanoma.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: February 21, 2023
    Assignee: MYRIAD MYPATH, LLC
    Inventors: Michael Bryan Warf, Benjamin Roa, Alexander Gutin, Darl Flake
  • GENES AND GENE SIGNATURE FOR DIAGNOSIS AND TREATMENT OF MELANOMA
    Publication number: 20220243275
    Abstract: Panels of biomarkers, methods and systems are disclosed for determining gene expression, and diagnosing and treating melanoma.
    Type: Application
    Filed: November 26, 2021
    Publication date: August 4, 2022
    Inventors: Darl FLAKE, Alexander GUTIN, Douglas ADAMS
  • GENES AND GENE SIGNATURES FOR DIAGNOSIS AND TREATEMENT OF MELANOMA
    Publication number: 20220098670
    Abstract: Panels of biomarkers, methods and systems are disclosed for determining gene expression, and diagnosing and treating melanoma.
    Type: Application
    Filed: May 20, 2021
    Publication date: March 31, 2022
    Applicant: MYRIAD MYPATH, LLC
    Inventors: Michael Bryan Warf, Benjamin Roa, Alexander Gutin, Darl Flake
  • Genes and gene signatures for diagnosis and treatment of melanoma
    Patent number: 11021752
    Abstract: Panels of biomarkers, methods and systems are disclosed for determining gene expression, and diagnosing and treating melanoma.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: June 1, 2021
    Assignee: Myriad Genetics, Inc.
    Inventors: Michael Bryan Warf, Benjamin Roa, Alexander Gutin, Darl Flake
  • GENES AND GENE SIGNATURES FOR DIAGNOSIS AND TREATMENT OF MELANOMA
    Publication number: 20200255908
    Abstract: Panels of biomarkers, methods and systems are disclosed for determining gene expression, and diagnosing and treating melanoma.
    Type: Application
    Filed: February 10, 2020
    Publication date: August 13, 2020
    Applicant: MYRIAD GENETICS, INC.
    Inventors: Michael Bryan WARF, Benjamin ROA, Alexander GUTIN, Darl FLAKE
  • ADJUSTED MULTI-BIOMARKER DISEASE ACTIVITY SCORE FOR INFLAMMATORY DISEASE ASSESSMENT
    Publication number: 20200249243
    Abstract: Provided herein are methods for assessing response to inflammatory disease therapy. The methods include performing immunoassays to generate scores based on quantitative data for expression of biomarkers relating to inflammatory biomarkers to assess disease activity in inflammatory diseases, e.g., rheumatoid arthritis. Also provided are methods of adjusting disease activity scores to account for variables that can influence such scores.
    Type: Application
    Filed: July 30, 2018
    Publication date: August 6, 2020
    Applicant: MYRIAD GENETICS, INC.
    Inventors: Ching Chang HWANG, David CHERNOFF, Alexander GUTIN, Darl FLAKE, Jerry LANCHBURY, Paul Scott EASTMAN, Eric SASSO
  • Genes and gene signatures for diagnosis and treatment of melanoma
    Patent number: 10612099
    Abstract: Panels of biomarkers, methods and systems are disclosed for determining gene expression, and diagnosing and treating melanoma.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: April 7, 2020
    Assignee: Myriad Genetics, Inc
    Inventors: Michael Bryan Warf, Benjamin Roa, Alexander Gutin, Darl Flake
  • GENES AND GENE SIGNATURES FOR DIAGNOSIS AND TREATMENT OF MELANOMA
    Publication number: 20190032144
    Abstract: Panels of biomarkers, methods and systems are disclosed for determining gene expression, and diagnosing and treating melanoma.
    Type: Application
    Filed: July 3, 2018
    Publication date: January 31, 2019
    Inventors: Darl Flake, Alexander Gutin, Douglas Adams
  • GENES AND GENE SIGNATURES FOR DIAGNOSIS AND TREATMENT OF MELANOMA
    Publication number: 20170198358
    Abstract: Panels of biomarkers, methods and systems are disclosed for determining gene expression, and diagnosing and treating melanoma.
    Type: Application
    Filed: December 22, 2016
    Publication date: July 13, 2017
    Inventors: Michael Bryan Warf, Benjamin Roa, Alexander Gutin, Darl Flake
  • CANCER PROGNOSIS SIGNATURES
    Publication number: 20170137890
    Abstract: The disclosure provides for molecular classification of disease and, particularly, molecular markers for breast cancer prognosis and methods and systems of use thereof.
    Type: Application
    Filed: October 21, 2016
    Publication date: May 18, 2017
    Inventors: Jerry Lanchbury, Alexander Gutin, Darl Flake
  • GENES AND GENE SIGNATURES FOR DIAGNOSIS AND TREATMENT OF MELANOMA
    Publication number: 20140271546
    Abstract: Panels of biomarkers, methods and systems are disclosed for determining gene expression, and diagnosing and treating melanoma.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Inventors: Bryan Warf, Benjamin Roa, Alexander Gutin, Darl Flake
  • HYPOXIA-RELATED GENE SIGNATURES FOR CANCER CLASSIFICATION
    Publication number: 20140212415
    Abstract: Biomarkers, particularly hypoxia-related genes, and methods using the biomarkers for molecular classification of disease are provided.
    Type: Application
    Filed: February 4, 2014
    Publication date: July 31, 2014
    Inventors: Alexander Gutin, Srikanth Jammulapati, Susanne Wagner, Julia Reid, Darl Flake
  • BRCA DEFICIENCY AND METHODS OF USE
    Publication number: 20140024028
    Abstract: The invention generally relates to a molecular classification of disease and particularly to methods and compositions for determining BRCA deficiency.
    Type: Application
    Filed: March 28, 2013
    Publication date: January 23, 2014
    Applicant: MYRIAD GENETICS, INC.
    Inventors: Kirsten Timms, Darl Flake, Jennifer Potter, Jerry Lanchbury
  • METHODS AND COMPOSITIONS FOR PREDICTING CANCER THERAPY RESPONSE
    Publication number: 20130005592
    Abstract: The invention generally relates to molecular diagnostics, and particularly to molecular markers for cancer therapy response and methods of use thereof.
    Type: Application
    Filed: September 10, 2010
    Publication date: January 3, 2013
    Applicants: Board of Regents of the University of Texas System, Myriad Genetics Incorporated
    Inventors: Steven Stone, Alexander Gutin, Darl Flake, Francisco J. Esteva, Dihua Yu