Patents by Inventor Darrell C. Conklin

Darrell C. Conklin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human serine protease
    Patent number: 6468776
    Abstract: Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. These enzymes are also used in a variety of diagnostic, therapeutic, and industrial contexts. Ztryp3 is a new member of the serine protease family.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: October 22, 2002
    Assignee: ZymoGenetics, Inc.
    Inventor: Darrell C. Conklin
  • Zalpha13: a human secreted protein
    Publication number: 20020151013
    Abstract: Secreted proteins perform many functions that are essential for the metabolism and differentiation of cells. As such, this class of proteins often provides therapeutically useful pharmaceuticals. The present invention provides a new human secreted protein, designated “Zalpha13.
    Type: Application
    Filed: October 31, 2001
    Publication date: October 17, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Zeren Gao
  • Testis specific protein
    Publication number: 20020151492
    Abstract: Tissue-specific markers can be used to enhance diagnosis, staging, and treatment of cancer, as well as to detect metastases of tumors derived from that tissue. The present invention provides a novel human gene, designated as “Zalpha16,” which is preferentially expressed in testicular tissue.
    Type: Application
    Filed: October 25, 2001
    Publication date: October 17, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Andrew L. Feldhaus, Susan D. Holderman
  • Multi-domain proteinase inhibitor
    Publication number: 20020146789
    Abstract: A multidomain proteinase inhibitor and materials and methods for making it are disclosed. Fragments of the inhibitor are also disclosed. The proteinase inhibitor or fragments thereof may be used as components of cell culture media, in protein purification, and in certain therapeutic and diagnostic applications.
    Type: Application
    Filed: March 27, 2001
    Publication date: October 10, 2002
    Inventors: Darrell C. Conklin, Zeren Gao
  • Novel protein zlmda2.
    Publication number: 20020115168
    Abstract: Novel polypeptides, polynucleotides encoding them, materials and methods for making them, antibodies that specifically bind to them, and methods of using the polypeptides, polynucleotides, and antibodies are disclosed. The polypeptides comprise at least nine contiguous amino acid residues of SEQ ID NO:2, and may be prepared as polypeptide fusions comprising heterologous sequences, such as affinity tags. The polypeptides and polynucleotides encoding them may be used within a variety of therepeutic, diagnostic, and research applications.
    Type: Application
    Filed: November 21, 2001
    Publication date: August 22, 2002
    Inventors: Darrell C. Conklin, Zeren Gao
  • Kunitz domain polypeptide zkun6
    Publication number: 20020110887
    Abstract: Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a sequence of amino acid residues as shown in SEQ ID NO:3, wherein the sequence is at least 80% identical to residues 6 through 56 of SEQ ID NO:2. Also disclosed are methods for making the proteinase inhibitors, and expression vectors and cultured cells that are useful within the methods. The proteinase inhibitors may be used as components of cell culture media, in protein purification, and in certain therapeutic and diagnostic applications.
    Type: Application
    Filed: December 14, 2001
    Publication date: August 15, 2002
    Applicant: ZymoGenetics, Inc.
    Inventor: Darrell C. Conklin
  • Human beta-1,3-galactosyltransferase
    Publication number: 20020098564
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for znssp6, a novel member of the galactosyltransferase family. The polypeptides, and polynucleotides encoding them, are cell-cell interaction and glycoprotein synthesis modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the znssp6 polypeptides.
    Type: Application
    Filed: October 22, 2001
    Publication date: July 25, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Gayle Yamamoto, Zeren Gao, Stephen R. Jaspers
  • Beta-1,3-galactosyltransferase homologs
    Patent number: 6416988
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for znssp2, a novel member of the galactosyltransferase family. The polypeptides, and polynucleotides encoding them, are cell-cell interaction and glycoprotein synthesis modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the znssp2 polypeptides.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: July 9, 2002
    Assignee: Zymogenetics, Inc.
    Inventors: Darrell C. Conklin, Gayle Yamamoto, Stephen R. Jaspers, Zeren Gao
  • Full length expressed polynucleotides and the polypeptides they encode
    Publication number: 20020086988
    Abstract: The present invention provides to polynucleotides and secreted proteins encoded by the polynucleotides. The proteins include a variety of fusion proteins, including fusions comprising a signal peptide selected from the group consisting of signal peptides shown in SEQ ID NO:M, wherein M is an even integer from 2 to 122, operably linked to a second polypeptide. The invention further provides therapeutic and diagnostic methods utilizing the polynucleotides, polypeptides, and antagonists of the polypeptides.
    Type: Application
    Filed: March 5, 2001
    Publication date: July 4, 2002
    Inventors: Darrell C. Conklin, Scott R. Presnell, David A. Adler
  • Novel FGF homolog ZFGF11
    Publication number: 20020081663
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zFGF11 a novel member of the FGF family, which is most closely related to FGF 19 at the amino acid sequence level. The present invention also includes antibodies to the zFGF11 polypeptides, and methods of using the polynucleotides and polypeptides.
    Type: Application
    Filed: January 5, 2001
    Publication date: June 27, 2002
    Inventors: Darrell C. Conklin, Zhi Chen
  • Helical cytokine zalpha33
    Patent number: 6406888
    Abstract: Novel cytokine polypeptides, materials and methods for making them, and method of use are disclosed. The polypeptides comprise at least nine contiguous amino acid residues of SEQ ID NO:2 or SEQ ID NO:4, and may be prepared as polypeptide fusions comprise heterologous sequences, such as affinity tags. The polypeptides and polynucleotides encoding them may be used within a variety of therapeutic, diagnostic, and research applications.
    Type: Grant
    Filed: June 14, 2000
    Date of Patent: June 18, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Zeren Gao
  • Mammalian alpha helical protein-1
    Publication number: 20020058801
    Abstract: Novel mammalian alpha helical polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.
    Type: Application
    Filed: August 16, 2001
    Publication date: May 16, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Si Lok, Darrell C. Conklin, Julia E. Parrish
  • Human 2-19 protein homologue, z219a
    Patent number: 6388064
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for z219a, a novel member of the human 2-19 protein family. The polypeptides, and polynucleotides encoding them, may be used for detecting human chromosomal abnormalities. The present invention also includes antibodies to the z219a polypeptides.
    Type: Grant
    Filed: October 6, 1998
    Date of Patent: May 14, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Hal Blumberg
  • Disulfide core polypeptides
    Publication number: 20020052468
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for a disulfide core protein (Zdsc1). The polypeptides, and polynucleotides encoding them, are serine proteinase inhibitors. Also disclosed are expression vectors containing polynucleotides which encode a Zdsc1 polypeptide, antibodies which specifically bind to Zdsc1 polypeptides and anti-idiotypic antibodies which neutralize the antibodies which specifically bind to Zdsc1 polypeptides.
    Type: Application
    Filed: January 10, 2001
    Publication date: May 2, 2002
    Applicant: ZymoGenetics, Inc.
    Inventor: Darrell C. Conklin
  • Educational kit and method containing novel alpha helical protein-34
    Patent number: 6380361
    Abstract: An educational kit comprised of novel a novel polypeptide, alpha helical protein-34 (Zalpha34), polynucleotides that encode Zalpha34 and antibodies to Zalpha34. The present invention also relates to polynucleotide and polypeptide molecules for Zalpha34. The polypeptides, and polynucleotides encoding them, are hormonal and may be used to promote spermatogenesis. The present invention also includes antibodies to the Zalpha34 polypeptides, which can be used to inhibit spermatogenesis.
    Type: Grant
    Filed: October 24, 2000
    Date of Patent: April 30, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, David W. Taft
  • Kunitz domain polypeptide zkun6
    Patent number: 6380354
    Abstract: Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a sequence of amino acid residues as shown in SEQ ID NO:3, wherein the sequence is at least 80% identical to residues 6 through 56 of SEQ ID NO:2. Also disclosed are methods for making the proteinase inhibitors, and expression vectors and cultured cells that are useful within the methods. The proteinase inhibitors may be used as components of cell culture media, in protein purification, and in certain therapeutic and diagnostic applications.
    Type: Grant
    Filed: September 1, 1999
    Date of Patent: April 30, 2002
    Assignee: ZymoGenetics, Inc.
    Inventor: Darrell C. Conklin
  • Soluble protein ZTMPO-1
    Patent number: 6372889
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for ZTMPO-1, a novel soluble protein with homology to emerin and the thymopoietins. The polypeptides, and polynucleotides encoding them are useful for modulating cellular proliferation and differentiation and may be used for diagnostic purposes. The present invention also includes antibodies to the ZTMPO-1 polypeptides.
    Type: Grant
    Filed: April 19, 1999
    Date of Patent: April 16, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Darrell C. Conklin, Theresa M. Farrah, Mark F. Maurer, Angelika Grossmann
  • Antibodies to kunitz domain polypeptides
    Publication number: 20020039748
    Abstract: Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a sequence of amino acid residues as shown in SEQ ID NO: 5, wherein the sequence is at least 90% identical to SEQ ID NO: 2. Also disclosed are methods for making the proteinase inhibitors, and expression vectors and cultured cells that are useful within the methods. The proteinase inhibitors. may be used as components of cell culture media, in protein purification, and in certain therapeutic and diagnostic applications.
    Type: Application
    Filed: February 6, 2001
    Publication date: April 4, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Donald C. Foster, Zeren Gao
  • Antibodies to lipocalin homologs
    Patent number: 6365716
    Abstract: The present invention is directed to antibodies to polypeptides for a member of the lipocalin family. The expression of the polypeptide is restricted to testis and mammary gland, particularly breast tumor tissue. The polypeptide has been designated zlipo1.
    Type: Grant
    Filed: July 11, 2000
    Date of Patent: April 2, 2002
    Assignee: ZymoGenetics, Inc.
    Inventor: Darrell C. Conklin
  • Beta-1,3-galactosyltransferase homolog, ZNSSP6
    Patent number: 6361985
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for znssp6, a novel member of the galactosyltransferase family. The polypeptides, and polynucleotides encoding them, are cell-cell interaction and glycoprotein synthesis modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the znssp6 polypeptides.
    Type: Grant
    Filed: January 12, 2000
    Date of Patent: March 26, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Gayle Yamamoto, Zeren Gao, Stephen R. Jaspers