Patents by Inventor Darrell E. Fox

Darrell E. Fox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes and intermediates for preparing 3(S)-[(5-chloro-1H-indole-2-carbonyl)-amino]-2(R)-hydroxy-4-phenyl-butyric acid
    Patent number: 6410750
    Abstract: The present invention provides novel processes for preparing 3(S)-[(5-chloro-1H-indole-2-carbonyl)-amino]-2(R)-hydroxy-4-phenyl-butyric acid. Also provided are novel intermediates used in those processes. Further, the 3(S)-[(5-chloro-1H-indole-2-carbonyl)-amino]-2(R)-hydroxy-4-phenyl-butyric acid prepared by the novel processes can be further reacted to yield known indole 2-carboxamides and derivatives thereof possessing glycogen phosphorylase inhibitory activity, which are useful in the treatment of mammals, especially human beings, having glycogen phosphorylase dependent diseases or conditions.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: June 25, 2002
    Assignee: Pfizer Inc.
    Inventors: Keith M. DeVries, Darrell E. Fox, Philip D. Hammen, Dennis J. Hoover, Jeffrey B. Jorgensen
  • Processes and intermediates for preparing 3-(1-piperazinyl)-1,2-benzisothiazole
    Patent number: 6111105
    Abstract: The present invention relates to processes for the preparation of 3-(1-piperazinyl)-1,2-benzoisothiazole or its pharmaceutically acceptable salt and to novel intermediates used in the process.
    Type: Grant
    Filed: October 15, 1998
    Date of Patent: August 29, 2000
    Assignee: Pfizer, Inc.
    Inventors: Darrell E. Fox, John F. Lambert, Terry G. Sinay, Stanley W. Walinsky
  • Process and intermediates for preparing naphthyridonecarboxylic acid salts
    Patent number: 5929240
    Abstract: This invention relates to novel processes and intermediates for the preparation of pharmaceutically acceptable acid salts, of the formula
    Type: Grant
    Filed: October 7, 1996
    Date of Patent: July 27, 1999
    Assignee: Pfizer Inc.
    Inventors: Tamim F. Braish, Darrell E. Fox, Timothy Norris, Peter R. Rose
  • Process for optically active 2-alkyl-2,5-diazabicyclo[2.2.1] heptanes
    Patent number: 5523413
    Abstract: 1S,4S and 1R,4R-2-Alkyl-2,5-diazabicyclo[2.2.1]-heptanes useful as intermediates in the synthesis of certain antibacterial quinolones, are prepared respectively, from trans-4-hydroxy-L-proline and trans-4-hydroxy-D-proline via multistep procedures.
    Type: Grant
    Filed: September 11, 1995
    Date of Patent: June 4, 1996
    Assignee: Pfizer Inc.
    Inventors: Tamim F. Braish, Darrell E. Fox
  • Process for optically active 2-alkyl-2,5-diazabicyclo[2.2.1]heptanes
    Patent number: 5475117
    Abstract: 1S,4S and 1R,4R-2-Alkyl-2,5-diazabicyclo[2.2.1]heptanes useful as intermediates in the synthesis of certain antibacterial quinolones, are prepared respectively, from trans-4-hydroxy-L-proline and trans-4-hydroxy-D-proline via multistep procedures.
    Type: Grant
    Filed: September 6, 1994
    Date of Patent: December 12, 1995
    Assignee: Pfizer, Inc.
    Inventors: Tamim F. Braish, Darrell E. Fox
  • Process for optically active 2-alkyl-2,5-diazabicyclo[2.2.1]heptanes
    Patent number: 5371235
    Abstract: 1S,4S and 1R,4R-2-Alkyl-2,5-diazabicyclo[2.2.1]heptanes useful as intermediates in the synthesis of certain antibacterial quinolones, are prepared respectively, from trans-4-hydroxy-L-proline and trans-4-hydroxy-D-proline via multistep procedures.
    Type: Grant
    Filed: June 10, 1992
    Date of Patent: December 6, 1994
    Assignee: Pfizer Inc.
    Inventors: Tamim F. Braish, Darrell E. Fox
  • Preparation of diazabicyclic Intermediates
    Patent number: 5196548
    Abstract: Diazabicyclo[2.2.1]heptane intermediates are prepared from 4-hydroxy-L-proline in a five step procedure, or from allo-4-hydroxy-D-proline, through a novel 2-(C.sub.1 -C.sub.6)alkyl-5-substituted-2,5-diazabicyclo[2.2.1]heptane intermediate. The diazabicycloheptanes are of use in the preparation of antibiotic quinolones.
    Type: Grant
    Filed: July 2, 1992
    Date of Patent: March 23, 1993
    Assignee: Pfizer Inc.
    Inventors: Tamim F. Braish, Darrell E. Fox
  • Optically active 2-alkyl-2,5-diazabicyclo[2.2.1]heptanes
    Patent number: 5157125
    Abstract: 1S, 4S and 1R,4R-2-Alkyl-2,5-diazabicyclo[2.2.1]-heptanes useful as intermediates in the synthesis of certain antibacterial quinolones, are prepared respectively, from trans-4-hydroxy-L-proline and trans-4-hydroxy-D-proline via multistep procedures.
    Type: Grant
    Filed: November 26, 1991
    Date of Patent: October 20, 1992
    Assignee: Pfizer Inc.
    Inventors: Tamin F. Braish, Darrell E. Fox
  • Process for optically active 2-alkyl-2,5-diazabicyclo(2.2.1)heptanes
    Patent number: 5095121
    Abstract: 1S,4S and 1R,4R-2-Alkyl-2,5-diazabicyclo[2.2.1]heptanes useful as intermediates in the synthesis of certain antibacterial quinolones, are prepared respectively, from trans-4-hydroxy-L-proline and trans-4-hydroxy-D-proline via multistep procedures.
    Type: Grant
    Filed: January 8, 1991
    Date of Patent: March 10, 1992
    Assignee: Pfizer Inc
    Inventors: Tamim F. Braish, Darrell E. Fox
  • Preparation of 2,5-diazabicyclo[2.2.1]heptanes and intermediates
    Patent number: 5036153
    Abstract: (R,R)-2,5-Diazabicyclo[ 2.2.1]heptanes are prepared from a compound of the formula ##STR1## wherein X and R.sub.2 are as defined herein, by heating with tosylchloride in pyridine, reacting the formed compound of the formula ##STR2## with a C.sub.1 -C.sub.6 alkylamine or ammonia, and reducing or hydrolyzing the formed compound of the formula ##STR3## wherein R.sub.1 is hydrogen or C.sub.1 -C.sub.6 alkyl.
    Type: Grant
    Filed: October 18, 1989
    Date of Patent: July 30, 1991
    Inventors: Tamim F. Braish, Darrell E. Fox
  • Process for optically active 2-alkyl-2,5-diazabicyclo(2.2.1) heptanes
    Patent number: 5013839
    Abstract: 1S,4S and 1R,4R-2-alkyl-2,5-diazabicyclo[2.2.1]-heptanes useful as intermediates in the synthesis of certain antibacterial quinolones, are prepared respectively, from trans-4-hydroxy-L-proline and trans-4-hydroxy-D-proline via multistep procedures.
    Type: Grant
    Filed: December 21, 1989
    Date of Patent: May 7, 1991
    Assignee: Pfizer Inc.
    Inventors: Tamim F. Braish, Darrell E. Fox