Patents by Inventor Darrell H. Carney

Darrell H. Carney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080241149
    Abstract: Disclosed are antibodies and antigen-binding fragments that bind to a complementary peptide having an amino acid sequence that is encoded by the complement of a nucleotide sequence encoding thrombin or a portion thereof. Such antibodies and antigen-binding fragments can be agonists or antagonists of thrombin receptor-mediated events. Also disclosed are methods of using the agonist antibodies and antigen-binding fragments of the invention to activate the non-proteolytically activated thrombin receptor (NPAR) in a subject in need of such treatment. In addition, methods of using the antagonist antibodies and antigen-binding fragments of the invention to inhibit activation of the NPAR in a subject in need of such treatment are disclosed.
    Type: Application
    Filed: September 14, 2006
    Publication date: October 2, 2008
    Inventors: Darrell H. Carney, John S. Bergmann, Gerald M. Fuller
  • Publication number: 20080131474
    Abstract: The present invention relates to a method for promoting cardiac tissue repair comprising administering to the cardiac tissue a therapeutically effective amount of an angiogenic thrombin derivative peptide and/or inhibiting or reducing vascular occlusion or restenosis. The invention also relates to methods of stimulating revascularization. In yet another embodiment, the invention relates to the use of thrombin derivative peptides in the manufacture of a medicament for the methods described herein.
    Type: Application
    Filed: April 13, 2007
    Publication date: June 5, 2008
    Inventor: Darrell H. Carney
  • Patent number: 7378500
    Abstract: Disclosed is a method of promoting healing of a chronic dermal skin ulcer, such as a diabetic ulcer, on a subject. The method comprises the step of contacting the chronic dermal skin ulcer with an effective amount of an agonist of the non-proteolytically activated thrombin receptor.
    Type: Grant
    Filed: April 4, 2006
    Date of Patent: May 27, 2008
    Assignee: Orthologic Corp.
    Inventor: Darrell H. Carney
  • Patent number: 7304035
    Abstract: Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site.
    Type: Grant
    Filed: January 18, 2005
    Date of Patent: December 4, 2007
    Assignee: Orthologic Corp.
    Inventors: Darrell H. Carney, Roger S. Crowther, David J. Simmons, Jinping Yang, William R. Redin
  • Patent number: 7291596
    Abstract: Disclosed are pharmaceutical compositions comprising a thrombin peptide derivatives and a chelating agent and/or a pharmaceutically acceptable thiol-containing compound. The pharmaceutical compositions optionally further comprise an antioxidant. Also, disclosed are methods for activating the non-proteolytically activated thrombin receptor in a subject in need of such treatment. The methods comprise the step of administering an effective amount of a thrombin peptide derivative in the pharmaceutical composition described above.
    Type: Grant
    Filed: December 30, 2004
    Date of Patent: November 6, 2007
    Assignee: Orthologic Corp.
    Inventors: David W. Hobson, Roger S. Crowther, Darrell H. Carney, Andrew Po Kwan Tang
  • Patent number: 7214661
    Abstract: The present invention relates to a method for promoting cardiac tissue repair comprising administering to the cardiac tissue a therapeutically effective amount of an angiogenic thrombin derivative peptide and/or inhibiting or reducing vascular occlusion or restenosis. The invention also relates to methods of stimulating revascularization. In yet another embodiment, the invention relates to the use of thrombin derivative peptides in the manufacture of a medicament for the methods described herein.
    Type: Grant
    Filed: December 2, 2005
    Date of Patent: May 8, 2007
    Assignee: OrthoLogic Corp.
    Inventor: Darrell H. Carney
  • Patent number: 7049294
    Abstract: Disclosed is a method of promoting healing of a chronic dermal skin ulcer, such as a diabetic ulcer, on a subject. The method comprises the step of contacting the chronic dermal skin ulcer with an effective amount of an agonist of the non-proteolytically activated thrombin receptor.
    Type: Grant
    Filed: January 27, 2004
    Date of Patent: May 23, 2006
    Assignee: Orthologic Corp.
    Inventor: Darrell H. Carney
  • Patent number: 7034001
    Abstract: The present invention relates to a method for promoting cardiac tissue repair comprising administering to the cardiac tissue a therapeutically effective amount of an angiogenic thrombin derivative peptide and/or inhibiting or reducing vascular occlusion or restenosis. The invention also relates to methods of stimulating revascularization. In yet another embodiment, the invention relates to the use of thrombin derivative peptides in the manufacture of a medicament for the methods described herein.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: April 25, 2006
    Assignee: OrthoLogic Corp.
    Inventor: Darrell H. Carney
  • Patent number: 6914050
    Abstract: Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: July 5, 2005
    Assignee: The Board of Regents, The University of Texas System
    Inventors: Darrell H. Carney, Roger S. Crowther, David J. Simmons, Jinping Yang, William R. Redin
  • Patent number: 6894027
    Abstract: Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site.
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: May 17, 2005
    Assignee: The Board of Regents, The University of Texas System
    Inventors: Darrell H. Carney, Roger S. Crowther, David J. Simmons, Jinping Yang, William R. Redin
  • Patent number: 6867190
    Abstract: The present invention relates to a method for promoting cardiac tissue repair comprising administering to the cardiac tissue a therapeutically effective amount of an angiogenic thrombin derivative peptide and/or inhibiting or reducing vascular occlusion or restenosis. The invention also relates to methods of stimulating revascularization. In yet another embodiment, the invention relates to the use of thrombin derivative peptides in the manufacture of a medicament for the methods described herein.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: March 15, 2005
    Assignee: The Board of Regents, The University of Texas System
    Inventor: Darrell H. Carney
  • Patent number: 6861407
    Abstract: The present invention relates to a method for promoting cardiac tissue repair comprising administering to the cardiac tissue a therapeutically effective amount of an angiogenic thrombin derivative peptide and/or inhibiting or reducing vascular occlusion or restenosis. The invention also relates to methods of stimulating revascularization. In yet another embodiment, the invention relates to the use of thrombin derivative peptides in the manufacture of a medicament for the methods described herein.
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: March 1, 2005
    Assignee: The Board of Regents, The University of Texas System
    Inventor: Darrell H. Carney
  • Patent number: 6855687
    Abstract: Disclosed is a method of stimulating cartilage growth, repair or regeneration at a site in a subject in need of such growth, repair or regeneration. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site. Also disclosed is a method of stimulating the proliferation and expansion of chrondrocytes in vitro. The method comprises culturing chrondrocytes in the presence of a stimulating amount of an NPAR agonist.
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: February 15, 2005
    Assignee: The Board of Regents The University of Texas System
    Inventors: Darrell H. Carney, Roger S. Crowther, Janet Stiernberg, John Bergmann
  • Patent number: 6815416
    Abstract: Disclosed is a method of stimulating cartilage growth, repair or regeneration at a site in a subject in need of such growth, repair or regeneration. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site. Also disclosed is a method of stimulating the proliferation and expansion of chrondrocytes in vitro. The method comprises culturing chrondrocytes in the presence of a stimulating amount of an NPAR agonist.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: November 9, 2004
    Assignee: The Board of Regents, The University of Texas System
    Inventors: Darrell H. Carney, Roger S. Crowther, Janet Stiernberg, John Bergmann
  • Publication number: 20040209819
    Abstract: Disclosed is a method of promoting healing of a chronic dermal skin ulcer, such as a diabetic ulcer, on a subject. The method comprises the step of contacting the chronic dermal skin ulcer with an effective amount of an agonist of the non-proteolytically activated thrombin receptor.
    Type: Application
    Filed: January 27, 2004
    Publication date: October 21, 2004
    Applicant: The Board of Regents, The University of Texas System
    Inventor: Darrell H. Carney
  • Patent number: 6630572
    Abstract: Thrombin is now known to mediate a number of potent biological effects on cells bearing high-affinity thrombin receptors. These effects depend, at least in part, upon receptor occupancy signals generated by thrombin's interaction with the high affinity thrombin receptor. The present inventors have formulated synthetic thrombin derivatives capable of selectively stimulating or inhibiting thrombin receptor occupancy signals. The stimulatory thrombin derivatives to bind to cell surface thrombin receptors and stimulate DNA synthesis in cells treated with non-mitogenic concentrations of alpha-thrombin or phorbol myristate acetate. Thus, these peptides, which have both a thrombin receptor binding domain and a segment of amino acids with a sequence common to a number of serine proteases, appear to generate receptor-occupancy dependent mitogenic signals.
    Type: Grant
    Filed: August 2, 2000
    Date of Patent: October 7, 2003
    Assignees: The Board of Regents, University of Texas Syatems, Pharmacia Corporation
    Inventors: Darrell H. Carney, Kevin C. Glenn
  • Patent number: 6627731
    Abstract: Thrombin is now known to mediate a number of potent biological effects on cells bearing high-affinity thrombin receptors. These effects depend, at least in part, upon receptor occupancy signals generated by thrombin's interaction with the high affinity thrombin receptor. The present inventors have formulated synthetic thrombin derivatives capable of selectively stimulating or inhibiting thrombin receptor occupancy signals. The stimulatory thrombin derivatives to bind to cell surface thrombin receptors and stimulate DNA synthesis in cells treated with non-mitogenic concentrations of alpha-thrombin or phorbol myristate acetate. Thus, these peptides, which have both a thrombin receptor binding domain and a segment of amino acids with a sequence common to a number of serine proteases, appear to generate receptor-occupancy dependent mitogenic signals.
    Type: Grant
    Filed: September 29, 1995
    Date of Patent: September 30, 2003
    Assignees: Pharmacia Corporation, The Board of Regents, Univeristy of Texas System
    Inventors: Darrell H. Carney, Kevin C. Glenn
  • Patent number: 6602978
    Abstract: These compositions are new synthetic peptides and antibodies which are potent chemotactic agents for human neutrophils, and methods for their use. The specificity of these peptides is amino acid sequence specific for binding to a heretofore unidentified receptor on the surface of neutrophils. Neutrophil response to this peptide is specific, since monocytes and fibroblasts do not show any expression of this receptor. Antibodies against these peptides block the chemotactic response. Such antibodies are useful to modulate neutrophil recruitment to a wound site for enhancing or inhibiting inflammation and early effects of wound healing.
    Type: Grant
    Filed: August 22, 2000
    Date of Patent: August 5, 2003
    Assignee: Chrysalis Biotechnology
    Inventors: Darrell H. Carney, Shyam Ramakrishnan
  • Publication number: 20020198154
    Abstract: Disclosed is a method of stimulating cartilage growth, repair or regeneration at a site in a subject in need of such growth, repair or regeneration. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site.
    Type: Application
    Filed: January 16, 2002
    Publication date: December 26, 2002
    Applicant: Univ. of Texas System, Board of Regents
    Inventors: Darrell H. Carney, Roger S. Crowther, Janet Stiernberg, John Bergmann
  • Publication number: 20020187933
    Abstract: The present invention relates to a method for promoting cardiac tissue repair comprising administering to the cardiac tissue a therapeutically effective amount of an angiogenic thrombin derivative peptide and/or inhibiting or reducing vascular occlusion or restenosis. The invention also relates to methods of stimulating revascularization. In yet another embodiment, the invention relates to the use of thrombin derivative peptides in the manufacture of a medicament for the methods described herein.
    Type: Application
    Filed: January 16, 2002
    Publication date: December 12, 2002
    Applicant: Univ. of Texas System, Board of Regents
    Inventor: Darrell H. Carney