Patents by Inventor Darrell Liu

Darrell Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NUCLEIC ACID AMPLIFICIATION TECHNIQUES AND METHODS FOR DETECTING BACTERIAL INFECTION
    Publication number: 20170073736
    Abstract: Sequence specific DNA amplification and analysis techniques are provided. In some aspects, methods of the embodiments comprise amplifying sequence from two regions of a target sequence in the presence of a blocking oligonucleotide (e.g., such as a phosphorothioate-containing oligonucleotide) that hybridizes to the target sequence between the two regions. In some specific embodiments, a method is provided for detecting bacteria (such as detecting gram-positive or gram-negative bacteria) in a biological sample using polymerase chain reaction (PCR).
    Type: Application
    Filed: July 29, 2016
    Publication date: March 16, 2017
    Inventors: Douglas Bryan LITWIN, Heidi B. KAPLAN, Catherine G. AMBROSE, Anahita DUA, John B. HOLCOMB, Charles E. WADE, Fernando ANDRADE, John Darrell LIU
  • Poly-gamma-glutamic conjugates for eliciting immune responses directed against bacilli
    Patent number: 7803386
    Abstract: Immunogenic compositions and methods for eliciting an immune response against B. anthracis and other bacilli are provided that include immunogenic conjugates of a poly-?-glutamic acid (?PGA) polypeptide of B. anthracis, or of another Bacillus that expresses a ?PGA polypeptide. The ?PGA conjugates elicit an effective immune response against B. anthracis, or against another Bacillus, in mammalian hosts to which the conjugates are administered.
    Type: Grant
    Filed: June 4, 2004
    Date of Patent: September 28, 2010
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Rachel Schneerson, Stephen Leppla, John B. Robbins, Joseph Shiloach, Joanna Kubler-Kielb, Darrell Liu, Fathy Majadly
  • Poly-gamma-glutamic conjugates for eliciting immune responses directed against bacilli
    Publication number: 20060134143
    Abstract: Immunogenic compositions and methods for eliciting an immune response against B. anthracis and other bacilli are provided that include immunogenic conjugates of a poly-?-glutamic acid (?PGA) polypeptide of B. anthracis, or of another Bacillus that expresses a ?PGA polypeptide. The ?PGA conjugates elicit an effective immune response against B. anthracis, or against another Bacillus, in mammalian hosts to which the conjugates are administered.
    Type: Application
    Filed: June 4, 2004
    Publication date: June 22, 2006
    Inventors: Rachel Schneerson, Stephen Leppla, John Robbins, Joseph Shiloach, Joanna Kubler-Kielb, Darrell Liu, Fathy Majadly
  • Methods for preparing immunogenic conjugates
    Publication number: 20050271675
    Abstract: Methods for making an immunogenic conjugate that includes a hapten or an antigen covalently linked to a carrier. The methods include reacting a first agent with a dihydrazide resulting in a hydrazino-modified first agent, wherein the first agent is a hapten, an antigen or a carrier; reacting a second agent with a benzaldehyde compound resulting in a benzaldehyde-modified second agent, wherein the second agent is a hapten, an antigen or a carrier, provided that the first agent or the second agent is a carrier; and reacting the hydrazine-modified first agent with the benzaldehyde-modified second agent resulting in an immunogenic conjugate comprising a hapten or an antigen covalently linked to a carrier via a hydrazone linkage.
    Type: Application
    Filed: December 6, 2004
    Publication date: December 8, 2005
    Inventors: Rachel Schneerson, Joanna Kubler-Kielb, Fathy Majadly, Stephen Leppla, John Robbins, Darrell Liu, Joseph Shiloah