Abstract: Provided herein are IL-21 muteins and fusion proteins comprising the same for use in methods of treating a disease. Related conjugates, nucleic acids, vectors, host cells, pharmaceutical compositions and kits are also provided herein. Methods of making the IL-21 muteins and fusion proteins comprising the same, as well as methods of treating a subject in need thereof, are provided by the present disclosure. Further provided are PD-1 antigen-binding proteins.

Abstract: Provided herein are IL-21 muteins and fusion proteins comprising the same for use in methods of treating a disease. Related conjugates, nucleic acids, vectors, host cells, pharmaceutical compositions and kits are also provided herein. Methods of making the IL-21 muteins and fusion proteins comprising the same, as well as methods of treating a subject in need thereof, are provided by the present disclosure. Further provided are PD-1 antigen-binding proteins.

Abstract: Provided herein are IL-21 muteins and fusion proteins comprising the same for use in methods of treating a disease. Related conjugates, nucleic acids, vectors, host cells, pharmaceutical compositions and kits are also provided herein. Methods of making the IL-21 muteins and fusion proteins comprising the same, as well as methods of treating a subject in need thereof, are provided by the present disclosure. Further provided are PD-1 antigen-binding proteins.

Abstract: The present invention relates to a method for modifying the density of a flowable material in need thereof comprising applying highly propagating ultrasonic energy at frequency of between about 16 kHz to about 40 kHz to the material wherein the highly propagating ultrasonic energy is uniformly distributed throughout the material thereby modifying the density of the material.

Abstract: A method for making a jelly confectionery comprising preparing a liquid jelly confectionery composition comprising bulk sweetener and a hydrocolloid gelling agent, cooking the liquid jelly confectionery composition, and depositing the liquid jelly confectionery composition into a mold, wherein the viscosity of the liquid jelly confectionery composition is temporarily modified for a period of time commencing prior to deposition of the liquid jelly confectionery into a mold.

Abstract: A Sonotrode for generating an ultrasonic field in industrial production processes such as chemical, food, petroleum, pharmaceutical, beverage or mining-related processes for reducing and eliminating foaming of liquid products has a compact one-piece form, wherein the sonotrode is provided with a main body part having a connector for connection with a high frequency generator and having a front face from which the ultrasonic field is directed to the desired spot or area of the product to be de-foamed, wherein the main body part has the shape of a compact block element and in that the front face is concave in shape in relation to a product surface such that the ultrasonic field is focused and directed to a specific area of a product foam to be treated in a concentrated form compared to a non-focused ultrasound.

Abstract: The present invention relates to a method for modifying the density of a flowable material in need thereof comprising applying highly propagating ultrasonic energy at frequency of between about 16 kHz to about 40 kHz to the material wherein the highly propagating ultrasonic energy is uniformly distributed throughout the material thereby modifying the density of the material.

Abstract: A method for making a jelly confectionery comprising preparing a liquid jelly confectionery composition comprising bulk sweetener and a hydrocolloid gelling agent, cooking the liquid jelly confectionery composition, and depositing the liquid jelly confectionery composition into a mould, wherein the viscosity of the liquid jelly confectionery composition is temporarily modified for a period of time commencing prior to deposition of the liquid jelly confectionery into a mould.

Abstract: A method for modifying the viscosity of pureed vegetable matter, said method including the step of applying relatively low-frequency ultrasonic energy (having a frequency in the range from about 16 kHz to 100 kHz) to said puree via a sonotrode in a manner such that cavitation of a water fraction in said puree is induced, and the cellular structure and cell wall material of the vegetable matter are degraded, thereby to increase the viscosity of said puree.

Abstract: In a process for beneficiating phosphate rock a slurry is provided having 30% to 70% by weight of a liquid phase and having a solid phase comprising clay, sand, and phosphate rock. In the process, the slurry is exposed to ultrasonic energy released from a sonotrode located within the slurry. The slurry may be exposed to the ultrasonic energy for less than 10 seconds. The ultrasonic energy may be produced by a piezoceramic transducer to have a resonance frequency within the range of from 16 kHz to 100 kHz. The ultrasonic energy may have an intensity within the range of from 0.0001 W/cm3 to about 1000 W/cm3. The ultrasonic energy may create cavitational forces within the slurry. After exposure to ultrasonic energy, clay and sand are separated from the phosphate rock, perhaps using an air flotation process and a cycloning process.

Abstract: An apparatus for repairing a crack in a vehicle windshield includes a high frequency vibration applicator and repair material. The high frequency vibration applicator includes a high frequency vibration generator, an elongate vibration delivery probe, and a handle grip for manipulation of the high frequency vibration applicator by a user. The vibration delivery probe delivers high frequency vibration from the generator to the windshield via a tip of the probe. A method of repairing a crack in a vehicle windshield includes infilling the crack with a repair material, applying to the windshield a tip of an elongate vibration delivery probe of a high frequency vibration applicator, and manipulating the high frequency vibration applicator to track the probe in a longitudinal direction of the crack.