Abstract: Provided herein are compounds that inhibit phosphodiesterase 5 (PDE5) and methods of use thereof. Also provided are pharmaceutical compositions and medicaments that include the compounds described herein as well as methods of treating gastrointestinal diseases and disorders such as intestinal cancers and inflammatory bowel disease.

Abstract: A man portable hydrogen source, the source comprising one or more hydrogen generating elements, an ignition control system and a pressure vessel. Each hydrogen generating element comprises a pellet holder provided with one or more recesses and a thermal insulation layer to reduce heat transfer to adjacent hydrogen generating elements; wherein at least one recess contains a pellet of a chemical mixture which on thermal decomposition evolves hydrogen gas; wherein the ignition control system comprises one or more igniters, associated with an individual pellet, and activation means to activate the igniters; and wherein the evolved hydrogen and hydrogen generating elements are contained within the pressure vessel.