Patents by Inventor Darren E. Higgins
Darren E. Higgins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10662423Abstract: Replicable libraries having discrete members in defined locations for screening for antigens to a pathogenic organism are provided. Also provided are methods for using such libraries as well as a specific antigen, CT788, which induces T-cell activation during a Chlamydia infection.Type: GrantFiled: February 12, 2018Date of Patent: May 26, 2020Assignee: President and Fellows of Harvard CollegeInventors: Darren E. Higgins, Michael N. Starnbach, Todd Gierahn, Nadia R. Roan
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Publication number: 20190032041Abstract: Replicable libraries having discrete members in defined locations for screening for antigens to a pathogenic organism are provided. Also provided are methods for using such libraries as well as a specific antigen, CT788, which induces T-cell activation during a Chlamydia infection.Type: ApplicationFiled: February 12, 2018Publication date: January 31, 2019Inventors: Darren E. HIGGINS, Michael N. STARNBACH, Todd GIERAHN, Nadia R. ROAN
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Patent number: 9920314Abstract: Replicable libraries having discrete members in defined locations for screening for antigens to a pathogenic organism are provided. Also provided are methods for using such libraries as well as a specific antigen, CT788, which induces T-cell activation during a Chlamydia infection.Type: GrantFiled: May 6, 2015Date of Patent: March 20, 2018Assignee: President and Fellows of Harvard CollegeInventors: Darren E. Higgins, Michael N. Starnbach, Todd Gierahn, Nadia R. Roan
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Publication number: 20160090589Abstract: Replicable libraries having discrete members in defined locations for screening for antigens to a pathogenic organism are provided. Also provided are methods for using such libraries as well as a specific antigen, CT788, which induces T-cell activation during a Chlamydia infection.Type: ApplicationFiled: May 6, 2015Publication date: March 31, 2016Inventors: Darren E. HIGGINS, Michael N. Starnbach, Todd Gierahn, Nadia R. Roan
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Patent number: 9051564Abstract: Replicable libraries having discrete members in defined locations for screening for antigens to a pathogenic organism are provided. Also provided are methods for using such libraries as well as a specific antigen, CT788, which induces T-cell activation during a Chlamydia infection.Type: GrantFiled: February 21, 2007Date of Patent: June 9, 2015Assignee: President and Fellows of Harvard CollegeInventors: Darren E. Higgins, Michael N. Starnbach, Todd Gierahn, Nadia R. Roan
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Publication number: 20140120129Abstract: Chlamydia antigens (e.g., polypeptides, polypeptide fragments, and fusion proteins) are provided. Also provided are vaccines and pharmaceutical compositions for treating or preventing a bacterial infection, such as Chlamydia, in a subject.Type: ApplicationFiled: January 3, 2014Publication date: May 1, 2014Applicant: President and Fellows of Harvard CollegeInventors: Darren E. HIGGINS, Todd Gierahn
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Patent number: 8637053Abstract: Chlamydia antigens (e.g., polypeptides, polypeptide fragments, and fusion proteins) are provided. Also provided are vaccines and pharmaceutical compositions for treating or preventing a bacterial infection, such as Chlamydia, in a subject.Type: GrantFiled: December 3, 2008Date of Patent: January 28, 2014Assignee: President and Fellows of Harvard CollegeInventors: Darren E. Higgins, Todd Gierahn
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Publication number: 20110076288Abstract: Replicable libraries having discrete members in defined locations for screening for antigens to a pathogenic organism are provided. Also provided are methods for using such libraries as well as a specific antigen, CT788, which induces T-cell activation during a Chlamydia infection.Type: ApplicationFiled: February 21, 2007Publication date: March 31, 2011Applicant: President and Fellows of Harvard CollegeInventors: Darren E. Higgins, Michael N. Starnbach, Todd Gierahn, Nadia R. Roan
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Publication number: 20100278854Abstract: Chlamydia antigens (e.g., polypeptides, polypeptide fragments, and fusion proteins) are provided. Also provided are vaccines and pharmaceutical compositions for treating or preventing a bacterial infection, such as Chlamydia, in a subject.Type: ApplicationFiled: December 3, 2008Publication date: November 4, 2010Inventor: Darren E. Higgins
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Publication number: 20100260791Abstract: Chlamydia antigens (e.g., polypeptides, polypeptide fragments, and fusion proteins) are provided. Also provided are vaccines and pharmaceutical compositions for treating or preventing a bacterial infection, such as Chlamydia, in a subject.Type: ApplicationFiled: August 1, 2008Publication date: October 14, 2010Applicant: President and Fellows of HarvardInventors: Darren E. Higgins, Todd Gierahn, Michael N. Starnbach, Nadia R. Roan
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Publication number: 20080166366Abstract: The invention provides methods and compositions relating to intracellular delivering of agents to eukaryotic cells. The compositions include microbial delivery vehicles such as nonvirulent bacteria comprising a first gene encoding a nonsecreted foreign cytolysin operably linked to a heterologous promoter and a second gene encoding a different foreign agent. The foreign agent may be a nucleic acid or protein, and is frequently bioactive in and therapeutic to the target eukaryote. In addition, the invention provides eukaryotic cells comprising the subject nonvirulent bacteria and nonhuman eukaryotic host organisms comprising such cells.Type: ApplicationFiled: September 26, 2007Publication date: July 10, 2008Inventors: Daniel A. Portnoy, Darren E. Higgins
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Publication number: 20040115221Abstract: The invention provides methods and compositions relating to intracellular delivering of agents to eukaryotic cells. The compositions include microbial delivery vehicles such as nonvirulent bacteria comprising a first gene encoding a nonsecreted foreign cytolysin operably linked to a heterologous promoter and a second gene encoding a different foreign agent. The foreign agent may be a nucleic acid or protein, and is frequently bioactive in and therapeutic to the target eukaryote. In addition, the invention provides eukaryotic cells comprising the subject nonvirulent bacteria and nonhuman eukaryotic host organisms comprising such cells.Type: ApplicationFiled: July 25, 2003Publication date: June 17, 2004Inventors: Daniel A. Portnoy, Darren E. Higgins
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Patent number: 6599502Abstract: The invention provides methods and compositions relating to intracellular delivering of agents to eukaryotic cells. The compositions include microbial delivery vehicles such as nonvirulent bacteria comprising a first gene encoding a nonsecreted foreign cytolysin operably linked to a heterologous promoter and a second gene encoding a different foreign agent. The foreign agent may be a nucleic acid or protein, and is frequently bioactive in and therapeutic to the target eukaryote. In addition, the invention provides eukaryotic cells comprising the subject nonvirulent bacteria and nonhuman eukaryotic host organisms comprising such cells.Type: GrantFiled: September 7, 2001Date of Patent: July 29, 2003Assignee: The Regents of the University of CaliforniaInventors: Daniel A. Portnoy, Darren E. Higgins
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Publication number: 20020142007Abstract: The invention provides methods and compositions relating to intracellular delivering of agents to eukaryotic cells. The compositions include microbial delivery vehicles such as nonvirulent bacteria comprising a first gene encoding a nonsecreted foreign cytolysin operably linked to a heterologous promoter and a second gene encoding a different foreign agent. The foreign agent may be a nucleic acid or protein, and is frequently bioactive in and therapeutic to the target eukaryote. In addition, the invention provides eukaryotic cells comprising the subject nonvirulent bacteria and nonhuman eukaryotic host organisms comprising such cells.Type: ApplicationFiled: September 7, 2001Publication date: October 3, 2002Inventors: Daniel A. Portnoy, Darren E. Higgins
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Patent number: 6287556Abstract: The invention provides methods and compositions relating to intracellular delivering of agents to eukaryotic cells. The compositions include microbial delivery vehicles such as nonvirulent bacteria comprising a first gene encoding a nonsecreted foreign cytolysin operably linked to a heterologous promoter and a second gene encoding a different foreign agent. The foreign agent may be a nucleic acid or protein, and is frequently bioactive in and therapeutic to the target eukaryote. In addition, the invention provides eukaryotic cells comprising the subject nonvirulent bacteria and nonhuman eukaryotic host organisms comprising such cells.Type: GrantFiled: December 21, 1999Date of Patent: September 11, 2001Assignee: The Regents of the University of CaliforniaInventors: Daniel A. Portnoy, Darren E. Higgins
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Patent number: 6004815Abstract: The invention provides methods and compositions relating to intracellular delivering of agents to eukaryotic cells. The compositions include microbial delivery vehicles such as nonvirulent bacteria comprising a first gene encoding a nonsecreted foreign cytolysin operably linked to a heterologous promoter and a second gene encoding a different foreign agent. The foreign agent may be a nucleic acid or protein, and is frequently bioactive in and therapeutic to the target eukaryote. In addition, the invention provides eukaryotic cells comprising the subject nonvirulent bacteria and nonhuman eukaryotic host organisms comprising such cells.Type: GrantFiled: August 13, 1998Date of Patent: December 21, 1999Assignee: The Regents of the University of CaliforniaInventors: Daniel A. Portnoy, Darren E. Higgins