Patents by Inventor Darren J. Schofield

Darren J. Schofield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monoclonal Antibodies That Bind or Neutralize Hepatitis B Virus
    Publication number: 20110097270
    Abstract: The present invention relates to the isolation and characterization of a novel neutralizing chimpanzee monoclonal antibody to hepatitis B virus. The invention provides such antibodies, fragments of such antibodies retaining hepatitis B virus-binding ability, fully human or humanized antibodies retaining hepatitis B virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
    Type: Application
    Filed: January 13, 2006
    Publication date: April 28, 2011
    Inventors: Darren J. Schofield, Suzanne U. Emerson, Robert H. Purcell
  • Anti-hepatitis a virus antibodies
    Patent number: 7635476
    Abstract: Chimpanzee monoclonal antibodies and antigen binding fragments including a ?1-chain CDR3 region that bind hepatitis A virus (HAV) antigen are disclosed herein. The antibodies neutralize HAV. Also disclosed are methods for using these antibodies and antigen binding fragments in the detection of hepatitis A virus, the inhibition of infection of a subject with hepatitis A virus, and in screening for agents that affect HAV.
    Type: Grant
    Filed: April 23, 2007
    Date of Patent: December 22, 2009
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Darren J. Schofield, Suzanne U. Emerson, Robert Purcell, II
  • Anti-hepatitis A virus antibodies
    Patent number: 7282205
    Abstract: Chimpanzee monoclonal antibodies and antigen binding fragments including a ?1-chain CDR3 region that bind hepatitis A virus (HAV) antigen are disclosed herein. The antibodies neutralize HAV. Also disclosed are methods for using these antibodies and antigen binding fragments in the detection of hepatitis A virus, the inhibition of infection of a subject with hepatitis A virus, and in screening for agents that affect HAV.
    Type: Grant
    Filed: November 7, 2002
    Date of Patent: October 16, 2007
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Darren J. Schofield, Suzanne U. Emerson, Robert H. Purcell
  • Anti-hepatitis a virus antibodies
    Publication number: 20040260067
    Abstract: Chimpanzee monoclonal antibodies and antigen binding fragments including a &ggr;1-chain CDR3 region that bind hepatitis A virus (HAV) antigen are disclosed herein. The antibodies neutralize HAV. Also disclosed are methods for using these antibodies and antigen binding fragments in the detection of hepatitis A virus, the inhibition of infection of a subject with hepatitis A virus, and in screening for agents that affect HAV.
    Type: Application
    Filed: May 4, 2004
    Publication date: December 23, 2004
    Inventors: Darren J. Schofield, Suzanne U Emerson, Robert H Purcell