Patents by Inventor Darren Janczak

Darren Janczak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of preparing oligomeric compounds using modified capping protocols
    Patent number: 9403865
    Abstract: Provided herein are methods for the solid phase synthesis of oligomeric compounds wherein at least one of the capping steps has been modified. More particularly, methods are provided wherein one or more of the capping steps is omitted or performed using reduced equivalents of acetic anhydride. In certain embodiments, the methods provide an enhanced purity profile. In certain embodiments, the methods provide an increased yield. The methods provided herein also provide at least an economic advantage over currently used methods in that reduced amounts of the mixture of capping reagents are required.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: August 2, 2016
    Assignees: Ionis Pharmaceuticals, Inc., Genzyme Corporation
    Inventors: Isaiah E. Cedillo, Darren Janczak, Phillip Michael Weaver
  • METHOD OF PREPARING OLIGOMERIC COMPOUNDS USING MODIFIED CAPPING PROTOCOLS
    Publication number: 20150218205
    Abstract: Provided herein are methods for the solid phase synthesis of oligomeric compounds wherein at least one of the capping steps has been modified. More particularly, methods are provided wherein one or more of the capping steps is omitted or performed using reduced equivalents of acetic anhydride. In certain embodiments, the methods provide an enhanced purity profile. In certain embodiments, the methods provide an increased yield. The methods provided herein also provide at least an economic advantage over currently used methods in that reduced amounts of the mixture of capping reagents are required.
    Type: Application
    Filed: August 15, 2013
    Publication date: August 6, 2015
    Applicants: Genzyme Corporation, Isis Pharmaceuticals, Inc.
    Inventors: Isaiah E. Cedillo, Darren Janczak, Phillip Michael Weaver