Patents by Inventor Darren Le Grand

Darren Le Grand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PREPARATION OF SUBSTITUTED 1,2-DIAMINOHETEROCYCLIC COMPOUND DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS
    Publication number: 20240300936
    Abstract: This invention relates to compounds which are microtubule associated serine/threonine-like kinase (MASTL) inhibitors and the use of the compounds in the treatment of diseases and medical conditions mediated by MASTL, for example in the treatment of cancer and other target related diseases.
    Type: Application
    Filed: June 9, 2022
    Publication date: September 12, 2024
    Applicant: AVELOS THERAPEUTICS INC.
    Inventors: Ki Seon BAEK, Ja Heouk KHOO, Soongyu CHOI, Young Whan PARK, Simon WARD, Darren LE GRAND, Ryan WEST, Penelope TURNER, Samuele MARAMAI, Tristan REUILLON
  • Pet imaging agents
    Patent number: 10865195
    Abstract: Preparation of novel 2-benzyl-5-methyl-2H-tetrazole derivatives of the formula (I) for use as PET imaging agents. The present invention relates to novel compounds of formula (I) their preparation and use as PET imaging agents for imaging techniques and diagnostics in the field of diseases and disorders mediated by or related to the enzyme autotaxin.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: December 15, 2020
    Assignee: Novartis AG
    Inventors: Yves Auberson, Emmanuelle Briard, Darren Le Grand, Berndt Oberhauser
  • PET Imaging Agents
    Publication number: 20200017474
    Abstract: Preparation of novel 2-benzyl-5-methyl-2H-tetrazole derivatives of the formula (I) for use as PET imaging agents. The present invention relates to novel compounds of formula (I) their preparation and use as PET imaging agents for imaging techniques and diagnostics in the field of diseases and disorders mediated by or related to the enzyme autotaxin.
    Type: Application
    Filed: September 24, 2019
    Publication date: January 16, 2020
    Applicant: Novartis AG
    Inventors: Yves Auberson, Emmanuelle Briard, Darren Le Grand, Berndt Oberhauser
  • PET Imaging agents
    Patent number: 10450298
    Abstract: Preparation of novel 2-benzyl-5-methyl-2H-tetrazole derivatives of the formula (I) for use as PET imaging agents. The present invention relates to novel compounds of formula (I) their preparation and use as PET imaging agents for imaging techniques and diagnostics in the field of diseases and disorders mediated by or related to the enzyme autotaxin.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: October 22, 2019
    Assignee: Novartis AG
    Inventors: Yves Auberson, Emmanuelle Briard, Darren Le Grand, Berndt Oberhauser
  • PET Imaging Agents
    Publication number: 20180273509
    Abstract: Preparation of novel 2-benzyl-5-methyl-2H-tetrazole derivatives of the formula (I) for use as PET imaging agents. The present invention relates to novel compounds of formula (I) their preparation and use as PET imaging agents for imaging techniques and diagnostics in the field of diseases and disorders mediated by or related to the enzyme autotaxin.
    Type: Application
    Filed: January 20, 2016
    Publication date: September 27, 2018
    Applicant: Novartis AG
    Inventors: Yves Auberson, Emmanuelle Briard, Darren Le Grand, Berndt Oberhauser
  • 1,3 Disubstituted azetidine derivatives for use as ccr-3 receptor antagonists in the treatment of inflammatory and allergic diseases
    Publication number: 20070043013
    Abstract: Compounds of formula Ia or Ib in free or salt form, wherein Ar, X1, X2, m, R1, Q, Y, R2 and R3 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by CCR-3, for example an inflammatory or allergic condition, particularly an inflammatory or obstructive airways disease. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
    Type: Application
    Filed: September 14, 2004
    Publication date: February 22, 2007
    Inventor: Darren Le Grand
  • Inhibitors of phosphatidylinositol 3-kinase
    Publication number: 20070032487
    Abstract: Compounds of formula I in free or salt form, wherein R1, R2, R3 and R4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
    Type: Application
    Filed: April 30, 2004
    Publication date: February 8, 2007
    Inventors: Ian Bruce, Bernard Cuenoud, Thomas Keller, Gaynor Pilgrim, Nicola Press, Darren Le Grand, Cathy Ritchie, Barbara Valade, Judy Hayler, Emma Budd
  • Azetidine derivatives as ccr-3 receptor antagonists
    Publication number: 20050222118
    Abstract: Compounds of formula I in free or salt form, wherein Ar, X, Y, R1, R2, R3, R5, m, n, p and q have the meanings as indicated in the specification, are useful for treating conditions mediated by CCR3. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
    Type: Application
    Filed: March 14, 2003
    Publication date: October 6, 2005
    Inventors: Darren Le Grand, Clive McCarthy, Clive Walker, John Woods