Patents by Inventor Darren M. Brown

Darren M. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metadherin polypeptides, encoding nucleic acids and methods of use
    Patent number: 8188051
    Abstract: Metadherin, a protein that controls metastasis, and variants of metadherin are described. DNA sequences encoding the same and methods of production are described. Therapies involving the application of metadherin, binding agents that bind to metadherin, such as antibodies, and expression modulating agents, such as siRNA, are described. The use of metadherin or metadherin variants for delivering desired substances to particular lung tissue is described. A method of diagnosing metastatic cells based on the presence of metadherin is described.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: May 29, 2012
    Assignee: The Burnham Institute
    Inventors: Erkki Ruoslahti, Darren M. Brown
  • METADHERIN POLYPEPTIDES, ENCODING NUCLEIC ACIDS AND METHODS OF USE
    Publication number: 20090221718
    Abstract: Metadherin, a protein that controls metastasis, and variants of metadherin are described. DNA sequences encoding the same and methods of production are described. Therapies involving the application of metadherin, binding agents that bind to metadherin, such as antibodies, and expression modulating agents, such as siRNA, are described. The use of metadherin or metadherin variants for delivering desired substances to particular lung tissue is described. A method of diagnosing metastatic cells based on the presence of metadherin is described.
    Type: Application
    Filed: December 16, 2008
    Publication date: September 3, 2009
    Inventors: Erkki Ruoslahti, Darren M. Brown
  • Metadherin polypeptides, encoding nucleic acids and methods of use
    Patent number: 7560242
    Abstract: Metadherin, a protein that controls metastasis, and variants of metadherin are described. DNA sequences encoding the same and methods of production are described. Therapies involving the application of metadherin, binding agents that bind to metadherin, such as antibodies, and expression modulating agents, such as siRNA, are described. The use of metadherin or metadherin variants for delivering desired substances to particular lung tissue is described. A method of diagnosing metastatic cells based on the presence of metadherin is described.
    Type: Grant
    Filed: November 10, 2004
    Date of Patent: July 14, 2009
    Assignee: The Burnham Institute
    Inventors: Erkki Ruoslahti, Darren M. Brown
  • Collagen-binding molecules that selectively home to tumor vasculature and methods of using same
    Patent number: 7488792
    Abstract: The present invention provides a conjugate containing a therapeutic agent linked to a homing molecule that selectively homes to tumor vasculature and selectively binds collagen such as non-helical collagen or collagen IV. In one embodiment, the conjugate contains a homing peptide or peptidomimetic that includes the amino acid sequence CREKA (SEQ ID NO: 1) or a conservative variant or peptidomimetic thereof.
    Type: Grant
    Filed: August 25, 2003
    Date of Patent: February 10, 2009
    Assignee: Burnham Institute for Medical Research
    Inventors: Erkki Ruoslahti, Markus Essler, Darren M. Brown