Patents by Inventor Darren Magda

Darren Magda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240067650
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Application
    Filed: March 10, 2023
    Publication date: February 29, 2024
    Inventors: David Tatum, Jide Xu, Darren Magda, Nathaniel Butlin
  • Publication number: 20240059668
    Abstract: There is a provided metal ion chelating agents capable of stably binding soft Lewis acid metal ions, metal ion chelates based on these chelating agents, and methods of using the compounds of the invention in diagnostic and therapeutics methods. Also provided are methods of sequestering soft Lewis acid metal ions. Exemplary soft Lewis acid metal ions are radionuclides.
    Type: Application
    Filed: October 21, 2021
    Publication date: February 22, 2024
    Inventors: Darren MAGDA, David TATUM
  • Patent number: 11691997
    Abstract: The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: July 4, 2023
    Assignee: LUMIPHORE, INC.
    Inventors: Nathaniel G. Butlin, Darren Magda, Jide Xu
  • Patent number: 11603371
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: March 14, 2023
    Assignee: LUMIPHORE, INC.
    Inventors: David Tatum, Jide Xu, Darren Magda, Nathaniel Butlin
  • Patent number: 11453652
    Abstract: The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: September 27, 2022
    Assignee: LUMIPHORE, INC.
    Inventors: Darren Magda, Jide Xu, Nathaniel G. Butlin
  • Publication number: 20210290787
    Abstract: The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications. In various embodiments, the invention described herein pertains to the diagnosis, imaging, and/or treatment of pathogenic cell populations. In particular, the invention described herein pertains to the diagnosis, imaging, and/or treatment of diseases caused by PSMA express-ing cells, such as prostate cancer cells, using compounds capable of targeting PSMA expressing cells.
    Type: Application
    Filed: June 19, 2019
    Publication date: September 23, 2021
    Inventors: Darren MAGDA, David TATUM, Nathaniel G. BUTLIN
  • Publication number: 20200405887
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Application
    Filed: March 7, 2019
    Publication date: December 31, 2020
    Inventors: David TATUM, Jide XU, Darren MAGDA, Nathaniel BUTLIN
  • Publication number: 20200062757
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Application
    Filed: March 25, 2019
    Publication date: February 27, 2020
    Inventors: David Tatum, Jide Xu, Darren Magda, Nathaniel Butlin
  • Publication number: 20200024234
    Abstract: The invention provides compounds such as chelating agents useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.
    Type: Application
    Filed: January 7, 2019
    Publication date: January 23, 2020
    Inventors: Jide Xu, Nathaniel Butlin, Darren Magda
  • Patent number: 10434186
    Abstract: The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: October 8, 2019
    Assignee: LUMIPHORE, INC.
    Inventors: Nathaniel G. Butlin, Darren Magda, Jide Xu
  • Patent number: 10273256
    Abstract: The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: April 30, 2019
    Assignee: LUMIPHORE, INC.
    Inventors: Nathaniel G. Butlin, Darren Magda, Jide Xu
  • Patent number: 10239878
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: March 26, 2019
    Assignee: LUMIPHORE, INC.
    Inventors: David Tatum, Jide Xu, Darren Magda, Nathaniel Butlin
  • Publication number: 20180298040
    Abstract: The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
    Type: Application
    Filed: June 22, 2018
    Publication date: October 18, 2018
    Inventors: Nathaniel G. BUTLIN, Darren MAGDA, Jide XU
  • Publication number: 20180194766
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Application
    Filed: March 7, 2018
    Publication date: July 12, 2018
    Inventors: David Tatum, Jide Xu, Darren Magda, Nathaniel Butlin
  • Publication number: 20170360956
    Abstract: The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
    Type: Application
    Filed: December 21, 2015
    Publication date: December 21, 2017
    Inventors: Nathaniel G. BUTLIN, Darren MAGDA, Jide XU
  • Publication number: 20170183365
    Abstract: The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
    Type: Application
    Filed: April 1, 2015
    Publication date: June 29, 2017
    Inventors: Nathaniel G. BUTLIN, Darren MAGDA, Jide XU
  • Patent number: 9408816
    Abstract: Provided herein are methods for using at least one histone deacetylase inhibitor to decrease cellular DNA repair activity, methods for monitoring the decrease of cellular DNA repair activity using at least one biomarker, methods of treating cancer by using at least one histone deacetylase inhibitor to decrease cellular DNA repair activity in combination therapy, methods of combination therapy where at least one histone deacetylase inhibitor interferes with a DNA repairing mechanism involving RAD51, methods for predicting a induction time period between a first administration of at least one histone deacetylase inhibitor and a second administration of at least one other therapeutic treatment, and pharmaceutical compositions for combination therapy.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: August 9, 2016
    Assignee: Pharmacyclics LLC
    Inventors: Shanthi Adimoolam, Joseph J. Buggy, Darren Magda, Richard Miller
  • Publication number: 20160221971
    Abstract: The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
    Type: Application
    Filed: November 15, 2013
    Publication date: August 4, 2016
    Applicant: LUMIPHORE, INC.
    Inventors: Darren Magda, Jide Xu, Nathaniel G. Butlin
  • Patent number: 8507531
    Abstract: Disclosed herein are novel zinc ionophores, zinc chelators and/or zinc complexes with enhanced aqueous solubility. Methods of treating cancer using at least one zinc ionophore and/or zinc chelator are also disclosed. Also disclosed herein are compositions and methods for treating cancer with combination therapy using at least one texaphyrin metal complex and at least one zinc ionophore or the respective pharmaceutically acceptable derivatives or salts thereof.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: August 13, 2013
    Inventors: Darren Magda, Jonathan L. Sessler
  • Publication number: 20110189088
    Abstract: The invention provides compounds such as chelating agents useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.
    Type: Application
    Filed: December 23, 2010
    Publication date: August 4, 2011
    Applicant: Lumiphore, Inc.
    Inventors: Jide Xu, Nathaniel G. Butlin, Darren Magda