Abstract: Disclosed herein are thieno[2,3-b:5,4-c?]dipyridin-8-amine and pyrido[4?,3?:4,5]thieno[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: A pair of upright wall panels are each provided with a sidewardly spaced pair of generally parallel but inclined guide grooves extending vertically along the outer face of the upright frame edge rails. A connector assembly including a main activator rod having a pair of wedge members threaded thereon in spaced relationship therealong is positioned between the opposed upright edge rails. The wedge members have wedgelike edge flanges which protrude into the grooves of the opposed upright edge rails. Rotation of the activating rod causes the wedge members to simultaneously move relative to the rod in opposite directions to effect gripping engagement with the groove walls to simultaneously effect a drawing together of the edge rails and alignment thereof.

Abstract: A sliding door having an improved handle and lock assembly associated therewith. The assembly enables a closed and locked sliding door to be unlocked and opened by manual application of a single-motion to the door handle, such as a substantially horizontally-directed force applied to the door handle in the opening direction to effect unlocking of the door followed by movement of the sliding door into an open position.

Abstract: A sliding door having an improved handle and lock assembly associated therewith. The assembly enables a closed and locked sliding door to be unlocked and opened by manual application of a single-motion to the door handle, such as a substantially horizontally-directed force applied to the door handle in the opening direction to effect unlocking of the door followed by movement of the sliding door into an open position.

Abstract: A corner connector arrangement which joins adjacent upright edges of at least two wall panels for maintaining the panels in angled relationship. The connector arrangement employs a connector post positioned between adjacent panel end edges. Each panel has a connecting bracket provided with outwardly protruding upper and lower flanges which respectively overlap upper and lower ends of the post. The post has suitable openings so that cabling can pass from interiorly of one panel through the post for passage into the interior of another panel. Elongate closure strips are secured to and extend longitudinally along opposite edges of the bracket associated with each panel. The closure strips have cantilevered flanges which are curved similar to and resiliently deflect into engagement with exterior peripheral surfaces on the post to enclose the post and the cabling therein. A separate closer strip that snaps onto the post may be used to enclose the post for two-panel connections.

Abstract: A wall system and particularly a load-bearing spine wall defined by rigidly connected spine panels which are usable in conjunction with and connectable to branch panels for defining workstations. These spine panels include an interior frame having plural hollow cross beams rigidly joined between parallel uprights. The cross beams have elongate slots extending lengthwise along the sidewalls thereof. Each side of the frame permits one or more removable covering tiles to be attached thereto for defining the exterior surface of the spine panel. Load-bearing components having cantilevered hangers can be engaged within the elongate slots which extend lengthwise of the cross beams. Vertically adjacent tiles have longitudinal edges spaced to define a narrow elongate passage therebetween which aligns with the mouth of a respectively adjacent hanger-accommodating slot.

Abstract: A wall system and particularly a load-bearing spine wall defined by rigidly connected spine panels which are usable in conjunction with and connectable to branch panels for defining workstations. These spine panels include an interior frame having plural hollow cross beams rigidly joined between parallel uprights. The cross beams have elongate slots extending lengthwise along the sidewalls thereof. Each side of the frame permits one or more removable covering tiles to be attached thereto for defining the exterior surface of the spine panel. Load-bearing components having cantilevered hangers can be engaged within the elongate slots which extend lengthwise of the cross beams. Vertically adjacent tiles have longitudinal edges spaced to define a narrow elongate passage therebetween which aligns with the mouth of a respectively adjacent hanger-accommodating slot.