Patents by Inventor Darren R. Shafren

Darren R. Shafren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF TREATING A MALIGNANCY IN A SUBJECT AND A PHARMACEUTICAL COMPOSITION FOR USE IN SAME
    Publication number: 20170348366
    Abstract: There is a disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognising at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the Picornaviridae family. Coxsackie A-group viruses have been found to be particularly suitable. The cell adhesion molecule is desirably a member of the immunoglobulin (Ig) superfamily. Typically, the complement regulatory protein will be DAF.
    Type: Application
    Filed: January 13, 2017
    Publication date: December 7, 2017
    Inventor: Darren R. Shafren
  • METHOD OF TREATING A MALIGNANCY IN A SUBJECT AND A PHARMACEUTICAL COMPOSITION FOR USE IN SAME
    Publication number: 20160250268
    Abstract: There is a disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognising at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the Picornaviridae family. Coxsackie A-group viruses have been found to be particularly suitable. The cell adhesion molecule is desirably a member of the immunoglobulin (Ig) superfamily. Typically, the complement regulatory protein will be DAF.
    Type: Application
    Filed: September 29, 2015
    Publication date: September 1, 2016
    Inventor: Darren R. Shafren
  • Method of Treating a Malignancy in a Subject and a Pharmaceutical Composition for Use in Same
    Publication number: 20150037287
    Abstract: There is a disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognising at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the Picornaviridae family. Coxsackie A-group viruses have been found to be particularly suitable. The cell adhesion molecule is desirably a member of the immunoglobulin (Ig) superfamily. Typically, the complement regulatory protein will be DAF.
    Type: Application
    Filed: March 31, 2014
    Publication date: February 5, 2015
    Applicant: Viralytics Limited
    Inventor: Darren R. Shafren
  • Methods for treating malignancies using coxsackieviruses
    Patent number: 8722036
    Abstract: There is a disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognising at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the Picornaviridae family. Coxsackie A-group viruses have been found to be particularly suitable. The cell adhesion molecule is desirably a member of the immunoglobulin (Ig) superfamily. Typically, the complement regulatory protein will be DAF.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: May 13, 2014
    Assignee: Viralytics Limited
    Inventor: Darren R. Shafren
  • Method of Treating a Malignancy in a Subject Via Direct Picornaviral-Mediated Oncolysis
    Publication number: 20100062020
    Abstract: There are provided methods for treatment of abnormal cells such as cancer cells in a mammal. The methods involve treating the mammal with virus selected from echoviruses and modified forms and combination thereof, which recognize ?2?1 for infectivity of the cells. There are also provided methods for screening viruses for use in a method of the invention as well as pharmaceutical compositions for use in the methods.
    Type: Application
    Filed: February 3, 2009
    Publication date: March 11, 2010
    Inventor: DARREN R. SHAFREN
  • Method of Treating a Malignancy in a Subject and a Pharmaceutical Composition for Use in Same
    Publication number: 20090123427
    Abstract: There is a disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognising at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the Picornaviridae family. Coxsackie A-group viruses have been found to be particularly suitable. The cell adhesion molecule is desirably a member of the immunoglobulin (Ig) superfamily. Typically, the complement regulatory protein will be DAF.
    Type: Application
    Filed: February 29, 2008
    Publication date: May 14, 2009
    Inventor: Darren R. Shafren
  • Method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis
    Patent number: 7485292
    Abstract: There are provided methods for treatment of abnormal cells such as cancer cells in a mammal. The methods involve treating the mammal with virus selected from echoviruses and modified forms and combination thereof, which recognize ?2?1 for infectivity of the cells. There are also provided methods for screening viruses for use in a method of the invention as well as pharmaceutical compositions for use in the methods.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: February 3, 2009
    Assignee: Viralytics Limited
    Inventor: Darren R. Shafren
  • Methods for treating malignancies expressing ICAM-1 using coxsackie a group viruses
    Patent number: 7361354
    Abstract: There is disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognizing at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the Picornaviridae family. Coxsackie A-group viruses have been found to be particularly suitable. The cell adhesion molecule is desirably a member of the immunoglobulin (Ig) superfamily. Typically, the complement regulatory protein will be DAF.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: April 22, 2008
    Assignee: Viralytics Limited
    Inventor: Darren R. Shafren