Patents by Inventor Darren Raymond Shafren

Darren Raymond Shafren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR THE TREATMENT OF BLADDER CANCER
    Publication number: 20160136211
    Abstract: The present invention relates to methods of treating bladder cancer with human enterovirus C (HEC) in combination with chemotherapy or radiation therapy. The present invention also relates to methods for increasing susceptibility of a cancer cell to infection by HEC.
    Type: Application
    Filed: June 13, 2014
    Publication date: May 19, 2016
    Inventors: Darren Raymond Shafren, Gough AU, Hardev Pandha, Guy Simpson
  • METHODS AND COMPOSITIONS FOR TREATMENT OF HEMATOLOGIC CANCERS
    Publication number: 20150273002
    Abstract: The present invention relates to oncolytic Picornaviruses and methods and compositions for treating subjects having hematologic cancers. These include methods and compositions for treatment of myeloma, using disclosed Picornavirus such as Coxsackievirus, in methods of direct or indirect administration to subjects and ex vivo purging of malignant cells within auto grafts prior to transplantation.
    Type: Application
    Filed: December 22, 2014
    Publication date: October 1, 2015
    Inventors: Gough Geoffrey Au, Darren Raymond Shafren
  • Methods and Compositions for Treatment of Hematologic Cancers
    Publication number: 20130164330
    Abstract: The present invention relates to oncolytic Picornaviruses and methods and compositions for treating subjects having hematologic cancers. These include methods and compositions for treatment of myeloma, using disclosed Picornavirus such as Coxsackievirus, in methods of direct or indirect administration to subjects and ex vivo purging of malignant cells within auto grafts prior to transplantation.
    Type: Application
    Filed: July 23, 2012
    Publication date: June 27, 2013
    Inventors: Gough Geoffrey Au, Darren Raymond Shafren
  • Modified Oncolytic Viruses
    Publication number: 20120328575
    Abstract: The present invention provides an isolated selected Picornavirus capable of lytically infecting or inducing apoptosis in a cell substantially in the absence of intercellular adhesion molecule-1 (ICAM-1), and methods for treating subjects.
    Type: Application
    Filed: January 20, 2012
    Publication date: December 27, 2012
    Inventors: Eva Susanne Johansson, Darren Raymond Shafren
  • Methods and compositions for treatment of hematologic cancers
    Patent number: 8236298
    Abstract: The present invention relates to oncolytic Picornaviruses and methods and compositions for treating subjects having hematologic cancers. These include methods and compositions for treatment of myeloma, using disclosed Picornavirus such as Coxsackievirus, in methods of direct or indirect administration to subjects and ex vivo purging of malignant cells within auto grafts prior to transplantation.
    Type: Grant
    Filed: August 22, 2005
    Date of Patent: August 7, 2012
    Assignee: Viralytics Limited
    Inventors: Gough Geoffrey Au, Darren Raymond Shafren
  • Modified oncolytic viruses
    Patent number: 8114416
    Abstract: An isolated selected Picornavirus capable of lytically infecting or killing a cell substantially in the absence of intercellular adhesion molecule-1 (ICAM-1).
    Type: Grant
    Filed: January 17, 2005
    Date of Patent: February 14, 2012
    Assignee: Viralytics Limited
    Inventors: Eva Susanne Johansson, Darren Raymond Shafren
  • METHOD AND COMPOSITION FOR TREATMENT OF NEOPLASMS
    Publication number: 20100104578
    Abstract: The invention relates to methods of treating a neoplasm in an animal, in particular treating a neoplasm in a human, through the use of isolated nucleic acid sequence, including synthetic viral RNA and complementary DNA, derived from one or more Picornaviruses. The invention also relates to compositions of isolated nucleic acids derived from one or more Picornaviruses, and to the use of isolated nucleic acids derived from one or more Picornaviruses for the manufacture of a medicament for the treatment of neoplasms in a mammal.
    Type: Application
    Filed: October 16, 2009
    Publication date: April 29, 2010
    Inventor: Darren Raymond Shafren
  • Method and Compositions for the Treatment of Hematologic Cancers
    Publication number: 20080193479
    Abstract: The present invention relates to oncolytic Picornaviruses and methods and compositions for treating subjects having hematologic cancers. These include methods and compositions for treatment of myeloma, using disclosed Picornavirus such as Coxsackievirus, in methods of direct or indirect administration to subjects and ex vivo purging of malignant cells within auto grafts prior to transplantation.
    Type: Application
    Filed: August 22, 2005
    Publication date: August 14, 2008
    Inventors: Gough Geoffrey Au, Darren Raymond Shafren
  • Method and Composition for Treatment of Neoplasms
    Publication number: 20080160031
    Abstract: The invention relates to methods of treating a neoplasm in an animal, in particular treating a neoplasm in a human, through the use of isolated nucleic acid sequence, including synthetic viral RNA and complementary DNA, derived from one or more Picornaviruses. The invention also relates to compositions of isolated nucleic acids derived from one or more Picornaviruses, and to the use of isolated nucleic acids derived from one or more Picornaviruses for the manufacture of a medicament for the treatment of neoplasms in a mammal.
    Type: Application
    Filed: January 17, 2006
    Publication date: July 3, 2008
    Applicant: Viralytics Limited
    Inventor: Darren Raymond Shafren
  • Modified Oncolytic Viruses
    Publication number: 20080057036
    Abstract: An isolated selected Picornavirus capable of lytically infecting or killing a cell substantially in the absence of intercellular adhesion molecule-1 (ICAM-1).
    Type: Application
    Filed: January 17, 2005
    Publication date: March 6, 2008
    Inventors: Eva Susanne Johansson, Darren Raymond Shafren