Abstract: A method of providing an underbalance in a wellbore that includes positioning a surge assembly within the wellbore; bypassing a differential chamber that extends along a portion of the length of the surge assembly when flowing fluid through a fluid passageway that extends along the length of the surge assembly; and placing the fluid passageway in fluid communication with the air chamber to create an underbalance in the fluid passageway.

Abstract: A method of providing an underbalance in a wellbore that includes positioning a surge assembly within the wellbore; bypassing a differential chamber that extends along a portion of the length of the surge assembly when flowing fluid through a fluid passageway that extends along the length of the surge assembly; and placing the fluid passageway in fluid communication with the air chamber to create an underbalance in the fluid passageway.

Abstract: The present invention relates to the diagnosis and treatment of B-cell disorders such as multiple myeloma (MM). In particular, the present invention relates to the treatment of B-cell disorders using ligands which bind to free lambda light chains expressed on the surface of lymphoid cancer cells.

Abstract: Disclosed herein is a media player. The media player may include a display, a network adapter, a processor, and a memory. The processor may be in electrical communication with the display and the network adapter. The memory may store instructions that, when executed by the processor, cause the processor to: validate login information received from a handheld computing device, and enter a service mode of operation upon validating the login information.

Abstract: Disclosed are systems and methods for transitioning from a first content to a second content on a display. The systems and methods may include: receiving, at a computing device comprising a processor, the first content and the second content; determining, by the computing device, a transition sequence for transitioning from the first content to the second content; and displaying, by the computing device, the transition sequence on a first panel of the display. The display divided into a plurality of panels.

Abstract: Disclosed herein is a media player. The media player may include a display, a network adapter, a processor, and a memory. The processor may be in electrical communication with the display and the network adapter. The memory may store instructions that, when executed by the processor, cause the processor to: validate login information received from a handheld computing device, and enter a service mode of operation upon validating the login information.

Abstract: The present application generally relates to topical formulations comprising monoterpenoid compounds which are effective inhibitors of FGF-5-dependent signaling in hair follicles or parts thereof, the manufacture of such topical formulations, and their use to reduce, delay or prevent loss of terminal hair caused by FGF-5 signaling in the hair follicle, such as in subjects suffering from, or having a propensity to develop, alopecia.

Abstract: The present application generally relates to topical formulations comprising monoterpenoid compounds which are effective inhibitors of FGF-5-dependent signalling in hair follicles or parts thereof, the manufacture of such topical formulations, and their use to reduce, delay or prevent loss of terminal hair caused by FGF-5 signalling in the hair follicle, such as in subjects suffering from, or having a propensity to develop, alopecia

Abstract: A method comprises providing a gun string assembly within a wellbore and perforating the wellbore using the gun string assembly. The gun string assembly comprises a plurality of perforating guns coupled in series. A first perforating gun of the plurality of perforating guns comprises a first portion of shaped charges, and a second perforating gun of the plurality of perforating guns comprises a second portion of shaped charges operably associated with a secondary pressure generator. The first perforating gun and the second perforating gun are configured in the gun string assembly to provide a pressure transient comprising one or more pressures at a location in the wellbore that meet one or more thresholds.

Abstract: A method comprises: a. determining a configuration of a gun string, b. determining, by a computer, a pressure transient at a location in a wellbore, c. comparing the one or more pressures with the one or more pressure thresholds at the location, and d. perforating the wellbore with the gun string using the determined configuration of the gun string when the one or more pressures meet the one or more pressure thresholds at the location. The location in the wellbore has one or more pressure thresholds, and the pressure transient comprises one or more pressures.

Abstract: A downhole tool gun string assembly comprises a first perforating gun operable to generate a first pressure at a first location in a wellbore, wherein the first perforating gun comprises a first plurality of perforating charges; a second perforating gun operable to generate a second pressure at a second location in the wellbore, wherein the second pressure is different from the first pressure and the second perforating gun comprises a second plurality of perforating charges, and wherein at least one of the second plurality of perforating charges is operably associated with a secondary pressure generator, where the first perforating gun and the second perforating gun are configured to maintain a pressure at a selected location in the wellbore below a threshold when the first and second perforating guns are activated substantially concurrently.

Abstract: A method comprises providing a gun string assembly within a wellbore and perforating the wellbore using the gun string assembly. The gun string assembly comprises a plurality of perforating guns coupled in series. A first perforating gun of the plurality of perforating guns comprises a first portion of shaped charges, and a second perforating gun of the plurality of perforating guns comprises a second portion of shaped charges operably associated with a secondary pressure generator. The first perforating gun and the second perforating gun are configured in the gun string assembly to provide a pressure transient comprising one or more pressures at a location in the wellbore that meet one or more thresholds.

Abstract: A method comprises: a. determining a configuration of a gun string, b. determining, by a computer, a pressure transient at a location in a wellbore, c. comparing the one or more pressures with the one or more pressure thresholds at the location, and d. perforating the wellbore with the gun string using the determined configuration of the gun string when the one or more pressures meet the one or more pressure thresholds at the location. The location in the wellbore has one or more pressure thresholds, and the pressure transient comprises one or more pressures.

Abstract: A perforating gun assembly for use in a wellbore. The perforating gun assembly includes a carrier gun body and a charge holder disposed within the carrier gun body. A plurality of shaped charges are supported within the carrier gun body. A secondary pressure generator is operably associated with at least one of the shaped charges. The secondary pressure generator optimizes the wellbore pressure regime immediately after detonation of the shaped charges by controlling the dynamic underbalance created by the empty gun chambers to prevent excessive dynamic underbalance which may detrimentally effect the perforating operation.

Abstract: Presented herein are systems and methods for processing sound signals for use with electronic speech systems. Sound signals are temporally parsed into frames, and the speech system includes a speech codebook having entries corresponding to frame sequences. The system identifies speech sounds in an audio signal using the speech codebook.

Abstract: A downhole tool gun string assembly comprises a first perforating gun operable to generate a first pressure at a first location in a wellbore, wherein the first perforating gun comprises a first plurality of perforating charges; a second perforating gun operable to generate a second pressure at a second location in the wellbore, wherein the second pressure is different from the first pressure and the second perforating gun comprises a second plurality of perforating charges, and wherein at least one of the second plurality of perforating charges is operably associated with a secondary pressure generator, where the first perforating gun and the second perforating gun are configured to maintain a pressure at a selected location in the wellbore below a threshold when the first and second perforating guns are activated substantially concurrently.

Abstract: A virtual lug loader includes a lug loader for loading workpieces in a flow direction into the spaced apart lugs on a lugged conveyor, wherein the workpieces are transversely oriented relative to the flow direction. The lug loader includes an array of pairs of endless conveyors for conveying the workpieces downstream, wherein each pair of endless conveyors in the array include first and second endless conveyors. The first and second endless conveyors are spaced laterally apart across the flow direction. Each are aligned substantially in the flow direction. The array forms a continuous upper surface in the flow direction for supporting the workpieces translating downstream in the flow direction. Each pair of endless conveyors in the array overlap adjacent pairs of endless conveyors in the array. At least one pair of endless conveyors in the array include independently actuable first and second drives independently driving their corresponding first and second endless conveyors.

Abstract: Optical Coherence Tomography (OCT) is a high-resolution, non-invasive technique to image subsurface tissue and tissue functions. A broadband light source illuminates an object and the reflected photons are processed using an interferometer, demodulated into inphase and quadrature components and then digitized. The captured data contains information about the velocity of the moving scatterers but current Doppler estimation algorithms have a limited velocity detection range. Using a two dimensional velocity estimation, Doppler OCT (DOCT) can be used for the detection of in vivo aortic blood flow rates of over 1 m/s peak velocity through an esophageal DOCT probe. Previous methods have used a transverse Kasai (TK) autocorrelation estimation to estimate the velocity which is good for slow velocities, such as in the microvasculature. By calculating the Kasai autocorrelation with a lag in the depth or axial direction, backscattered frequency information is obtained which yields high velocity rate information.

Abstract: A perforating gun assembly for use in a wellbore. The perforating gun assembly includes a carrier gun body and a charge holder disposed within the carrier gun body. A plurality of shaped charges are supported within the carrier gun body. A secondary pressure generator is operably associated with at least one of the shaped charges. The secondary pressure generator optimizes the wellbore pressure regime immediately after detonation of the shaped charges by controlling the dynamic underbalance created by the empty gun chambers to prevent excessive dynamic underbalance which may detrimentally effect the perforating operation.

Abstract: Presented herein are systems and methods for generating an adaptive noise codebook for use with electronic speech systems. The noise codebook includes a plurality of entries which may be updated based on environmental noise sounds. The speech system includes a speech codebook and the adaptive noise codebook. The system identifies speech sounds in an audio signal using the speech and noise codebooks.