Abstract: Disclosed is a compound of formula (I): in which all symbols are defined in the description. Also disclosed are pharmaceutical compositions including the compounds, methods of making the compounds, kits comprising the compounds and methods of using the compounds to treat disorders associated with dysregulation of TREK-1, TREK-2 or both TREK-1 and TREK-2 in a mammal.

Abstract: Disclosed is a compound of formula (I): in which all symbols are defined in the description. Also disclosed are pharmaceutical compositions including the compounds, methods of making the compounds, kits comprising the compounds and methods of using the compounds to prevent and/or treat disorders associated with dysregulation of TREK-1, TREK-2 or both TREK-1 and TREK-2 in a mammal.

Abstract: An apparatus, system, and method are disclosed for making sandwiches. A bladeless sandwich making apparatus is provided with lower and upper tools having sandwich receiving cavities configured to accommodate sandwich ingredients and a mechanism for mounting configured to operate as a hinge and as a handle. Bread layers and filling may be placed within the apparatus in an open position. A filling material cup may be used for filling preparation. Beneficially, the apparatus may include an impression bar or plate to imprint design on an outer sandwich surface or for sandwich separation. The upper tool is configured to engage the lower tool to remove sandwich crusts and seal sandwich edges. The crustless sandwich with sealed edges may be consumed, stored, or heated. A method is disclosed for making sandwiches without crusts and sealed edges with or without designs on the sandwich surface.