Patents by Inventor Darren Shafren

Darren Shafren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination method for treatment of cancer
    Patent number: 11389495
    Abstract: The invention relates to methods of treating tumours comprising delivering an oncolytic virus or oncolytic viral RNA via direct injection or systemic administration or intravesicular administration to the tumour or cancer in combination with the co-administration of an immuno-stimulatory agent via the systemic route to a mammal.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: July 19, 2022
    Assignee: MERCK SHARP & DOHME LLC
    Inventors: Darren Shafren, Gough Geoffrey Au
  • COMBINATION METHOD FOR TREATMENT OF CANCER
    Publication number: 20200297788
    Abstract: The invention relates to methods of treating tumours comprising delivering an oncolytic virus or oncolytic viral RNA via direct injection or systemic administration or intravesicular administration to the tumour or cancer in combination with the co-administration of an immuno-stimulatory agent via the systemic route to a mammal.
    Type: Application
    Filed: April 29, 2020
    Publication date: September 24, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Darren Shafren, Gough Geoffrey Au
  • COMBINATION METHOD FOR TREATMENT OF CANCER
    Publication number: 20190134119
    Abstract: The invention relates to methods of treating tumours comprising delivering an oncolytic virus or oncolytic viral RNA via direct injection or systemic administration or intravesicular administration to the tumour or cancer in combination with the co-administration of an immuno-stimulatory agent via the systemic route to a mammal.
    Type: Application
    Filed: January 11, 2018
    Publication date: May 9, 2019
    Inventors: Darren Shafren, Gough Geoffrey Au
  • METHODS FOR THE TREATMENT OF BLADDER CANCER
    Publication number: 20190134120
    Abstract: The present invention relates to methods of treating bladder cancer with human enterovirus C (HEC) in combination with chemotherapy or radiation therapy. The present invention also relates to methods for increasing susceptibility of a cancer cell to infection by HEC.
    Type: Application
    Filed: August 3, 2018
    Publication date: May 9, 2019
    Inventors: DARREN SHAFREN, Gough Au, Hardev Pandha, Guy Simpson
  • COMBINATION METHOD FOR TREATMENT OF CANCER
    Publication number: 20170000832
    Abstract: The invention relates to methods of treating tumours comprising delivering an oncolytic virus or oncolytic viral RNA via direct injection or systemic administration or intravesicular administration to the tumour or cancer in combination with the co-administration of an immuno-stimulatory agent via the systemic route to a mammal.
    Type: Application
    Filed: February 27, 2015
    Publication date: January 5, 2017
    Inventors: Darren Shafren, Gough Geoffrey Au
  • Method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis
    Publication number: 20060134778
    Abstract: There are provided methods for treatment of abnormal cells such as cancer cells in a mammal. The methods involve treating the mammal with virus selected from echoviruses and modified forms and combination thereof, which recognise ?2?1 for infectivity of the cells. There are also provided methods for screening viruses for use in a method of the invention as well as pharmaceutical compositions for use in the methods.
    Type: Application
    Filed: December 18, 2003
    Publication date: June 22, 2006
    Inventor: Darren Shafren