Abstract: Methods of producing bioconjugates of O-antigen polysaccharides covalently linked to a carrier protein using recombinant host cells are provided. The recombinant host cells used in the methods described herein encode a particular oligosaccharyl transferase enzyme depending on the O-antigen polysaccharide bioconjugate to be produced. The oligosaccharyl transferase enzymes can be PglB oligosaccharyl transferase or variants thereof. Also provided are compositions containing the bioconjugates, and methods of using the bioconjugates and compositions described herein to vaccinate a subject against extra-intestinal pathogenic E. coli. (ExPEC).

Abstract: Stents and/or implants including a reinforcement member. An illustrative transluminal implant may include an elongated tubular body extending from first end region to a second end region. The elongated tubular body may comprise a scaffolding forming a plurality of cells, a first flange adjacent to the first end region, a second flange adjacent to the second end region, and a saddle region extending between the first flange and the second flange. The saddle region may have an outer diameter less than an outer diameter of the first flange and the second flange. A reinforcement member may be disposed within a lumen of the elongated tubular body and within the first flange.

Abstract: A system and a method are disclosed for providing recommendations for sets of security operations for improving security of documents created or executed within an online document system. A supplier entity may select sets of security operations to be performed for a request provided to a signing entity. The online document system computes an aggregate measure of security for the selected sets of security operations and compares it to a threshold measure of security. If the aggregate measure is less than the threshold measure, the online document system uses a machine-learned model to identify additional sets of security operations that when added, results in an updated aggregate measure of security greater than the threshold. The additional sets of security operations are presented to the supplier entity for inclusion within a security operation workflow in combination with the selected sets of security operations.

Abstract: A computing system helps a user in an extended reality (XR) learning experience achieve mastery through personalized, programmable and conversational coaching. One aspect is that the XR learning experience may consist of a plurality of tasks associated with the user. A second aspect is that the XR learning experience can define different types of conversational interventions triggered by the computing system at various times. A third aspect is that some tasks or interventions can make use of a conversational assistant. A fourth aspect is that as the user is going through the XR learning experience, the system determines which, if any, interventions can be triggered based on the user's state.

Abstract: A method includes receiving an input histology image, processing, using a cell classification model, the input histology image to generate one or more lymphocyte density maps within the input histology image, and performing morphological image processing on the one or more lymphocyte density maps to identify one or more TLS regions within the input histology image. Each TLS region is represented by a respective cluster of lymphocyte cells. For each corresponding TLS region of the one or more TLS regions identified in the input histology image, the method also includes extracting, from the respective cluster of lymphocyte cells, a respective set of TLS features, and processing, using a TLS classification model, the respective set of TLS features to classify the corresponding TLS region as one of a first TLS maturation state, a second TLS maturation state, or a third TLS maturation state.

Abstract: A computing system generates an extended reality environment for an end user. The extended reality environment includes a plurality of tasks and a plurality of goals to be achieved by the end user. The computing system receives input data from an extended reality system associated with the end user. The computing system updates a progress of the end user through the plurality of tasks and the plurality of goals based on the input data. The computing system receives a voice command from the end user. The voice command corresponds to a statement uttered by the end user within the extended reality environment. The computing system processes the voice command to generate a response to the voice command. The computing system causes the response to appear within the extended reality environment as an audible, visual or haptic feedback response to the voice command.

Abstract: A computing system helps a user in an extended reality (XR) learning experience achieve mastery through personalized, programmable and conversational coaching. One aspect is that the XR learning experience may consist of a plurality of tasks associated with the user. A second aspect is that the XR learning experience can define different types of conversational interventions triggered by the computing system at various times. A third aspect is that some tasks or interventions can make use of a conversational assistant. A fourth aspect is that as the user is going through the XR learning experience, the system determines which, if any, interventions can be triggered based on the user's state.

Abstract: A networked onboarding system that includes an onboarding accelerator (OA) and a request for amendment (RFA) module or application. The onboarding accelerator is a software solution or algorithm that is configured to operate to provide an automated and customizable end-to-end onboarding solution for users or subscribers (e.g., brokers, custodians, corporations, fund administrators, managers, service providers, and the like). The onboarding accelerator functions during client onboarding to integrate entity data, document collection, KYC (know your customer) and tax profile validation, regulatory protocols and self-declarations, legal and credit agreements, and operational set up into a seamless solution. The RFA module operates to enable a user or subscriber to initiate and execute amendments to add, remove, and modify legal entities (e.g., counterparty amendments) from its existing trading agreements with other subscribers to the services provided by the new onboarding system.

Abstract: Described are aircraft door assemblies comprising a stationary portion comprising at least one translation track and a movable portion comprising at least one channel. The movable portion is slidably coupled to the stationary portion via at least an attachment plate. The aircraft door assembly comprises a locked state and an unlocked state. In the locked state, the attachment plate and the movable portion are slidable as a unit relative to the stationary portion along the at least one translation track. In the unlocked state, the movable portion is slidable relative to the attachment plate and the stationary portion along the at least one channel.

Abstract: A computing system generates an extended reality environment for an end user. The extended reality environment includes a plurality of tasks and a plurality of goals to be achieved by the end user. The computing system receives input data from an extended reality system associated with the end user. The computing system updates a progress of the end user through the plurality of tasks and the plurality of goals based on the input data. The computing system receives a voice command from the end user. The voice command corresponds to a statement uttered by the end user within the extended reality environment. The computing system processes the voice command to generate a response to the voice command. The computing system causes the response to appear within the extended reality environment as an audible, visual or haptic feedback response to the voice command.

Abstract: The present invention provides compositions and methods for targeting an antigen to leukocytes, delivering an antigen to leukocytes, increasing antigen uptake by leukocytes, and/or enhancing an immune response. In some embodiments, compositions and methods of the present invention comprise a conjugate comprising an antigen and a plant lectin or a mimetic thereof.