Patents by Inventor Darren Weber
Darren Weber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240110899Abstract: A method for determining the amount of chromogranin A (CgA) in a sample includes: (a) purifying CgA in the sample; (b) adding an internal standard; (c) ionizing CgA and the internal standard to produce one or more CgA ion(s) and one or more internal standard ion(s) detectable by mass spectrometry; (d) determining the amount of the ion(s) from step (c) by mass spectrometry; and (e) correlating the amount of CgA in the sample to the amount of ion(s) measured in step (d).Type: ApplicationFiled: December 12, 2023Publication date: April 4, 2024Applicant: Quest Diagnostics Investments LLCInventors: Darren Weber, Michael P. Caufield, Michael McPhaul, Scott Goldman, Nigel Clarke
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Patent number: 11929243Abstract: Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.Type: GrantFiled: June 13, 2022Date of Patent: March 12, 2024Assignee: QUEST DIAGNOSTICS INVESTMENTS LLCInventors: Darren Weber, Nigel Clarke
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Patent number: 11885780Abstract: Provided are methods for detecting chromogranin A by mass spectrometry. In another aspect, provided herein are methods for quantitating chromogranin A by mass spectrometry. In another aspect, provided herein are methods for prognosis of or measuring the size of neuroendocrine tumors by mass spectrometry.Type: GrantFiled: January 24, 2022Date of Patent: January 30, 2024Assignee: Quest Diagnostics Investments LLCInventors: Darren Weber, Michael P. Caufield, Michael McPhaul, Scott Goldman, Nigel Clarke
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Publication number: 20220349897Abstract: Provided are methods for the detection or quantitation of amyloid beta. In a particular aspect, provided herein are methods for detecting amyloid beta or fragments thereof by mass spectrometry. In another aspect, provided herein are methods for determining the ratio of amyloid beta 42 (A?42) to amyloid beta 40 (A?40). In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.Type: ApplicationFiled: June 13, 2022Publication date: November 3, 2022Applicant: Quest Diagnostics Investments LLCInventors: Diana Tran, Darren Weber, Nigel Clarke
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Publication number: 20220310375Abstract: Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.Type: ApplicationFiled: June 13, 2022Publication date: September 29, 2022Applicant: Quest Diagnostics Investments LLCInventors: Darren Weber, Nigel Clarke
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Patent number: 11360098Abstract: Provided are methods for the detection or quantitation of amyloid beta. In a particular aspect, provided herein are methods for detecting amyloid beta or fragments thereof by mass spectrometry. In another aspect, provided herein are methods for determining the ratio of amyloid beta 42 (A?42) to amyloid beta 40 (A?40). In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.Type: GrantFiled: September 27, 2016Date of Patent: June 14, 2022Assignee: Quest Diagnostics Investments LLCInventors: Diana Tran, Darren Weber, Nigel Clarke
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Patent number: 11361953Abstract: Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.Type: GrantFiled: July 31, 2018Date of Patent: June 14, 2022Assignee: Quest Diagnostics Investments IncoporatedInventors: Darren Weber, Nigel Clarke
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Publication number: 20220163494Abstract: Provided are methods for detecting chromogranin A by mass spectrometry. In another aspect, provided herein are methods for quantitating chromogranin A by mass spectrometry. In another aspect, provided herein are methods for prognosis of or measuring the size of neuroendocrine tumors by mass spectrometry.Type: ApplicationFiled: January 24, 2022Publication date: May 26, 2022Applicant: Quest Diagnostics Investments LLCInventors: Darren Weber, Michael P. Caufield, Michael McPhaul, Scott Goldman, Nigel Clarke
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Patent number: 11231401Abstract: Provided are methods for detecting chromogranin A by mass spectrometry. In another aspect, provided herein are methods for quantitating chromogranin A by mass spectrometry. In another aspect, provided herein are methods for prognosis of or measuring the size of neuroendocrine tumors by mass spectrometry.Type: GrantFiled: March 15, 2019Date of Patent: January 25, 2022Assignee: Quest Diagnostics Investments LLCInventors: Darren Weber, Michael P. Caufield, Michael McPhaul, Scott Goldman, Nigel Clarke
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Publication number: 20190285594Abstract: Provided are methods for detecting chromogranin A by mass spectrometry. In another aspect, provided herein are methods for quantitating chromogranin A by mass spectrometry. In another aspect, provided herein are methods for prognosis of or measuring the size of neuroendocrine tumors by mass spectrometry.Type: ApplicationFiled: March 15, 2019Publication date: September 19, 2019Applicant: Quest Diagnostics Investments LLCInventors: Darren Weber, Michael Caufield, Michael McPhaul, Scott Goldman, Nigel Clarke
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Publication number: 20190206666Abstract: Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.Type: ApplicationFiled: July 31, 2018Publication date: July 4, 2019Applicant: Quest Diagnostics Investments LLCInventors: Darren Weber, Nigel Clarke
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Publication number: 20170089917Abstract: Provided are methods for the detection or quantitation of amyloid beta. In a particular aspect, provided herein are methods for detecting amyloid beta or fragments thereof by mass spectrometry. In another aspect, provided herein are methods for determining the ratio of amyloid beta 42 (A?42) to amyloid beta 40 (A?40). In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.Type: ApplicationFiled: September 27, 2016Publication date: March 30, 2017Applicant: Quest Diagnostics Investments LLCInventors: Diana Tran, Darren Weber, Nigel Clarke
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Publication number: 20160349221Abstract: Mass spectrometric methods are described for determining the amount of analyte in a sample collected by a microsampling device. Provided herein are methods directed to quantitating the amount of an analyte in a sample by extracting an analyte from a sample collected by a microsampling device, purifying the sample by liquid chromatography, ionizing the analyte to generate one or more ions detectable by mass spectrometry; and determining the amount of the one or more ions by mass spectrometry. The amount of analyte in the sample is related to the amount of analyte in the patient.Type: ApplicationFiled: May 27, 2016Publication date: December 1, 2016Applicant: Quest Diagnostics Investments LLCInventors: Scott Goldman, Mildred Goldman, Leslie Edinboro, Diana Tran, Julia Addiss, Darren Weber, Porus Mistry, Nigel Clarke
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Publication number: 20070256963Abstract: A plugged filter detection system includes a valve housed within a cavity defining an initial inlet for receiving fluid at an inlet pressure before fluid enters a filter, a final inlet for receiving fluid at an outlet pressure after the fluid exits the filter, and a switch port for directing fluid to a switch to activate the switch. The inlet pressure biases the valve in a first direction and the outlet pressure biases the valve in a second direction substantially opposing the first direction. The valve is movable from a first position to a second position to unblock the switch port, thereby allowing the switch to be activated when inlet pressure is greater than outlet pressure. A spring preferably biases the valve in the second direction, such that inlet pressure must be greater than outlet pressure by at least the spring constant to allow switch activation.Type: ApplicationFiled: May 3, 2006Publication date: November 8, 2007Inventors: Charles Long, Darren Weber
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Publication number: 20060094555Abstract: An electro-hydraulic control mechanism for use with a multi-speed transmission includes a pair of logic valves, which are manipulated during the ratio interchanges and the ratio establishment by aiding in the distribution of fluid pressure from a plurality of trim valves. The logic valves are retained in specific drive ranges in the event of electrical discontinuance.Type: ApplicationFiled: October 28, 2004Publication date: May 4, 2006Inventors: Charles Long, Phillip McCauley, Darren Weber
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Publication number: 20050211295Abstract: A control for parallel hybrid transmission has a valve mechanism, which is operable to supply fluid pressure to a torque-transmitting mechanism with or without the operation of the vehicle engine. The valve mechanism is responsive to an electrically driven pump to supply fluid pressure whenever the engine is discontinued and the electric driven pump is operated.Type: ApplicationFiled: March 25, 2004Publication date: September 29, 2005Inventors: Charles Long, Darren Weber