Abstract: Methods of promoting wound healing in a subject is disclosed. The method include applying a Granzyme B (Granzyme B) inhibitor to the wound. The wound may be a skin wound. The Granzyme B inhibitor may be comprised of nucleic acids, or peptides, including but not limited to antibodies, or small molecules.

Abstract: A rotational connector for mounting optical fibers for alignment with a laser source wherein the rotational connector enables rotation of the optical fiber while still retaining alignment with the source of laser energy. The connector includes a ferrule having a cylindrical portion having which is rotatably positioned within the housing of the source of laser energy and is adapted to receive and hold the optical fibers in a bore which runs through the cylindrical portion. The ferrule includes a disc portion which is mounted between thrust bearings which are oppositely disposed on the outer surfaces of the disc portion. The result is that the ferrule is free to rotate and yet cannot be translated with respect to the source of laser energy.

Abstract: The disclosure relates to a device for use in removing undesired material, e.g., an occlusion or plaque, from a duct or blood vessel within a patient's body. The device comprises a catheter adapted to be disposed within a duct and having a distal end portion with a tip and a tapered surface extending from the tip to the side of the catheter. The catheter has a lumen extending through the length thereof. The intersection of the lumen and the tapered surface forming an elongated opening. Pulsed laser energy is applied by an optical fiber extending through the lumen to the elongated openings and thereby the undesired material. An inflatable bladder is provided for positioning the distal end portion of the catheter adjacent the inner surface of the duct to position the elongated opening adjacent the undesired material to be removed. A filament extending through the catheter and connected to the distal end portion can be rotated at the proximal end of the catheter to rotatably position the distal portion thereof.